Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Melissa, Mun"'
Air sparging for prevention of antibody disulfide bond reduction in harvested CHO cell culture fluid
Autor:
Michael W. Laird, Melissa Mun, Melody Trexler-Schmidt, James Dvornicky, Yung-Hsiang Kao, Stefanie Khoo, Aline Do Minh
Publikováno v:
Biotechnology and Bioengineering. 112:734-742
During the scale-up of several Chinese Hamster Ovary (CHO) cell monoclonal antibody production processes, significant reduction of the antibody interchain disulfide bonds was observed. The reduction was correlated with excessive mechanical cell shear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ced097672e49e0a33ed5565ecfa502f2
https://doi.org/10.1002/bit.25495
https://doi.org/10.1002/bit.25495
Air sparging for prevention of antibody disulfide bond reduction in harvested CHO cell culture fluid
Autor:
Melissa, Mun, Stefanie, Khoo, Aline, Do Minh, James, Dvornicky, Melody, Trexler-Schmidt, Yung-Hsiang, Kao, Michael W, Laird
Publikováno v:
Biotechnology and bioengineering. 112(4)
During the scale-up of several Chinese Hamster Ovary (CHO) cell monoclonal antibody production processes, significant reduction of the antibody interchain disulfide bonds was observed. The reduction was correlated with excessive mechanical cell shear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e1d1f2c507f02d37bca28f6373180ba5
https://pubmed.ncbi.nlm.nih.gov/25384896
https://pubmed.ncbi.nlm.nih.gov/25384896
Autor:
Boyan Zhang, Natarajan Vijayasankaran, Robert Kiss, Steve Meier, Yi Yang, Amy Lim, Martin Gawlitzek, Feng Li, Sharat Varma, Melissa Mun, Silvana R. Arevalo, Trevor E. Swartz
Publikováno v:
Biotechnology progress. 29(5)
As the industry moves toward subcutaneous delivery as a preferred route of drug administration, high drug substance concentrations are becoming the norm for monoclonal antibodies. At such high concentrations, the drug substance may display a more int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7024764cbe1169772f115cc58c0a7cba
https://pubmed.ncbi.nlm.nih.gov/23804462
https://pubmed.ncbi.nlm.nih.gov/23804462
Publikováno v:
Molecular biotechnology. 45(3)
The goal of quality by design (QbD) in cell culture manufacturing is to develop manufacturing processes which deliver products with consistent critical quality attributes (CQAs). QbD approaches can lead to better process understanding through the use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c6e747731edcb219f10763062bd1c51
https://pubmed.ncbi.nlm.nih.gov/20300882
https://pubmed.ncbi.nlm.nih.gov/20300882