Výsledky vyhledávání - "Melisa L. Budde"

Akademický článek

Ex vivo SIV-specific CD8 T cell responses in heterozygous animals are primarily directed against peptides presented by a single MHC haplotype.

Autor: Justin M Greene, Emily N Chin, Melisa L Budde, Jennifer J Lhost, Paul J Hines, Benjamin J Burwitz, Karl W Broman, Jennifer E Nelson, Thomas C Friedrich, David H O'Connor

Publikováno v: PLoS ONE, Vol 7, Iss 8, p e43690 (2012)

The presence of certain MHC class I alleles is correlated with remarkable control of HIV and SIV, indicating that specific CD8 T cell responses can effectively reduce viral replication. It remains unclear whether epitopic breadth is an important feat

Externí odkaz: https://doaj.org/article/959eeb45e7fd4d15941657eb9c3e824a

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Transcriptionally Abundant Major Histocompatibility Complex Class I Alleles Are Fundamental to Nonhuman Primate Simian Immunodeficiency Virus-Specific CD8 + T Cell Responses

Autor: David H. O’Connor, Benjamin J. Burwitz, Ericka A. Becker, Jennifer J. Lhost, Melisa L. Budde, William H. Hildebrand, Guang Lan Zhang, Charles M. Burns, Julie A. Karl, Roger W. Wiseman, Benjamin N. Bimber, Shelby L. O’Connor, Vladimir Brusic

Publikováno v: Journal of Virology. 85:3250-3261

Simian immunodeficiency virus (SIV)-infected macaques are the preferred animal model for human immunodeficiency virus (HIV) vaccines that elicit CD8 + T cell responses. Unlike humans, whose CD8 + T cell responses are restricted by a maximum of six HL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85e4cc1f41145981be5cbe05fcf0fa58
https://doi.org/10.1128/jvi.02355-10

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Elimination of tumorigenic stem cells from differentiated progeny and selection of definitive endoderm reveals a Pdx1+ foregut endoderm stem cell lineage

Autor: Joseph F. Magliocca, Victoria L. Browning, Jon S. Odorico, Jeffrey Nelson, Fabiola Merriam, Benjamin Ziehr, Melisa L. Budde, Brenda Kahan, Nathan R. Treff

Publikováno v: Stem Cell Research. 6:143-157

Embryonic stem cell (ESC) derivatives offer promise for generating clinically useful tissues for transplantation, yet the specter of producing tumors in patients remains a significant concern. We have developed a simple method that eliminates the tum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::731195fd414e8ebad4bbb4920e5a9533
https://doi.org/10.1016/j.scr.2010.10.003

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Integrin α4β7 Is Downregulated on the Surfaces of Simian Immunodeficiency Virus SIVmac239-Infected Cells

Autor: Jennifer J. Lhost, Melisa L. Budde, Dawn M. Dudley, David H. O’Connor, Eva G. Rakasz

Publikováno v: Journal of Virology. 84:6344-6351

Simian immunodeficiency virus (SIV) and human immunodeficiency virus (HIV) infection results in an early and enduring depletion of intestinal CD4 + T cells. SIV and HIV bind integrin α4β7, thereby facilitating infection of lymphocytes that home to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74836637854e7413e49292922f0191bc
https://doi.org/10.1128/jvi.00430-10

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Generation and Characterization of Novel Tetracycline-Inducible Pancreatic Transcription Factor-Expressing Murine Embryonic Stem Cell Lines

Autor: Nathan R. Treff, Melisa L. Budde, Jon S. Odorico, Zachary J. Kastenberg, Robert K. Vincent

Publikováno v: Stem Cells and Development. 15:953-962

Pancreatic development in mammals is controlled in part by the expression and function of numerous genes encoding transcription factors. Yet, how these regulate each other and their target genes is incompletely understood. Embryonic stem (ES) cells h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe334881332e5e6de6120a8fe92b5a7
https://doi.org/10.1089/scd.2006.15.953

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Differentiation of Embryonic Stem Cells Conditionally Expressing Neurogenin 3

Autor: Victoria L. Browning, Robert K. Vincent, Vivek Kapur, Joseph F. Magliocca, Jon S. Odorico, Nathan R. Treff, Melisa L. Budde

Publikováno v: STEM CELLS. 24:2529-2537

Expression of the proendocrine gene neurogenin 3 (Ngn3) is required for the development of pancreatic islets. To better characterize the molecular events regulated by Ngn3 during development, we have determined the expression profiles of murine embry

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::017f247b7f11ae42f2c4c0938b1d797e
https://doi.org/10.1634/stemcells.2006-0082

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T cell response specificity and magnitude against SIVmac239 are not concordant in major histocompatibility complex-matched animals

Autor: Thomas C. Friedrich, Jason T. Weinfurter, Emily N. Chin, Shelby L. O’Connor, Melisa L. Budde, Justin M. Greene, David H. O’Connor, Max Harris, Brian T Cain, Matthew Scarlotta, Ngoc H Pham

Publikováno v: Retrovirology

Background CD8+ T cell responses, restricted by major histocompatibility complex (MHC) class I molecules, are critical to controlling human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) replication. Previous studies ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5907fb304d3b29a7efbe98183c40ca26
https://doi.org/10.1186/1742-4690-10-116

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Specific CD8+ T cell responses correlate with control of simian immunodeficiency virus replication in Mauritian cynomolgus macaques

Autor: Emma Gostick, Brian T Cain, David Price, Jason T. Weinfurter, Ngoc H Pham, Matthew Scarlotta, Max Harris, Thomas C. Friedrich, Jeffrey D. Lifson, Ericka A. Becker, Emily N. Chin, David H. O’Connor, Melisa L. Budde, Shelby L. O’Connor, Justin M. Greene, Michael Piatak, Adam J. Ericsen

Specific major histocompatibility complex (MHC) class I alleles are associated with an increased frequency of spontaneous control of human and simian immunodeficiency viruses (HIV and SIV). The mechanism of control is thought to involve MHC class I-r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab1e28ed8cdb0a4102ca561aa3ee9b86

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Ex vivo SIV-specific CD8 T cell responses in heterozygous animals are primarily directed against peptides presented by a single MHC haplotype

Autor: Paul J. Hines, Benjamin J. Burwitz, Jennifer E. Nelson, Justin M. Greene, David H. O’Connor, Karl W. Broman, Melisa L. Budde, Thomas C. Friedrich, Jennifer J. Lhost, Emily N. Chin

Publikováno v: PLoS ONE
PLoS ONE, Vol 7, Iss 8, p e43690 (2012)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7c5981087b4a035f6312e5641d8d264
https://pubmed.ncbi.nlm.nih.gov/22928016

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PRED mafa

Autor: Jennifer J. Lhost, William H. Hildebrand, Guang Lan Zhang, David H. O’Connor, Melisa L. Budde, Vladimir Brusic

Publikováno v: BCB

PREDmafa is a computational system for prediction of peptide binding to three transcriptionally abundant major histocompatibility complex (MHC) class I alleles of Mauritian cynomolgus macaque, an important animal model for the study of human disease.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0011a65982b7f15fbe0fad87b7a721e5
https://doi.org/10.1145/2147805.2147908

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