Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Melisa D Castro Eiro"'
Autor:
María A Natale, Gonzalo Cesar, Maria G Alvarez, Melisa D Castro Eiro, Bruno Lococo, Graciela Bertocchi, María C Albareda, Susana A Laucella
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 2, p e0007168 (2019)
[This corrects the article DOI: 10.1371/journal.pntd.0006998.].
Externí odkaz:
https://doaj.org/article/a4f83c4f25774bd2bad16fb1cf55a4eb
Autor:
Claudia Pengue, Gonzalo Cesar, María Gabriela Alvarez, Graciela Bertocchi, Bruno Lococo, Rodolfo Viotti, María Ailén Natale, Melisa D Castro Eiro, Silvia S Cambiazzo, Nancy Perroni, Myriam Nuñez, María Cecilia Albareda, Susana A Laucella
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0218260 (2019)
Chronic inflammation, as a consequence of the persistent infection with Trypanosoma cruzi, leads to continuous activation of the immune system in patients with chronic Chagas disease. We have previously shown that increased sera levels of soluble P-s
Externí odkaz:
https://doaj.org/article/119c5d54b9ea49fca77448b54c8579b9
Autor:
María A Natale, Gonzalo Cesar, María G Alvarez, Melisa D Castro Eiro, Bruno Lococo, Graciela Bertocchi, María C Albareda, Susana A Laucella
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 12, p e0006998 (2018)
BackgroundThe severity of cardiac disease in chronic Chagas disease patients is associated with different features of T-cell exhaustion. Here, we assessed whether the ability of T cells to secrete IFN-γ in response to T. cruzi was linked to disrupti
Externí odkaz:
https://doaj.org/article/d293c8b24f0c41e68873f852c2eead89
Autor:
Damián E Pérez-Mazliah, Melisa D Castro Eiro, María Gabriela Álvarez, Bruno Lococo, Graciela Bertocchi, Gonzalo César, María A Natale, María C Albareda, Rodolfo Viotti, Susana A Laucella
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 10, p e0006887 (2018)
BACKGROUND:Chronic infection with Trypanosoma cruzi leads to a constant stimulation of the host immune system. Monocytes, which are recruited in response to inflammatory signals, are divided into classical CD14hiCD16-, non-classical CD14loCD16+ and i
Externí odkaz:
https://doaj.org/article/160c3633ea1245b29e1e11f90c289243
Autor:
Manzhi Zhao, Ling Li, Caoimhe H. Kiernan, Melisa D. Castro Eiro, Floris Dammeijer, Marjan van Meurs, Inge Brouwers-Haspels, Merel E. P. Wilmsen, Dwin G. B. Grashof, Harmen J. G. van de Werken, Rudi W. Hendriks, Joachim G. Aerts, Yvonne M. Mueller, Peter D. Katsikis
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Cytotoxic CD8 + T cell (CTL) exhaustion is driven by chronic antigen stimulation. Reversing CTL exhaustion with immune checkpoint blockade (ICB) has provided clinical benefits in different types of cancer. We, therefore, investigated whether
Externí odkaz:
https://doaj.org/article/894d1a0cf952487080d6943e463aba2e
Autor:
Ling Li, Manzhi Zhao, Caoimhe H. Kiernan, Melisa D. Castro Eiro, Marjan van Meurs, Inge Brouwers-Haspels, Merel E. P. Wilmsen, Dwin G. B. Grashof, Harmen J. G. van de Werken, Rudi W. Hendriks, Yvonne M. Mueller, Peter D. Katsikis
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionCytotoxic CD8+ T cell (CTL) exhaustion is a dysfunctional state of T cells triggered by persistent antigen stimulation, with the characteristics of increased inhibitory receptors, impaired cytokine production and a distinct transcriptiona
Externí odkaz:
https://doaj.org/article/3847fcbb75c24886b8cbbde00a41f92f
Autor:
Melisa D. Castro Eiro, María A. Natale, María G. Alvarez, Araceli Castro, Débora Seigelshifer, Rodolfo Viotti, Marisa Fernández, Luis Mazzuoccolo, Bruno Lococo, Graciela L. Bertocchi, Gonzalo Cesar, María C. Albareda, María J. Elias, María B. Caputo, Eduardo Gaddi, Jeanette Balbaryski, Carlos A. Vigliano, Susana A. Laucella
Publikováno v:
Microbiology Spectrum. 10
Dermatitis is the most common adverse event during treatment with benznidazole in chronic Chagas disease and is probably mediated by T cells. A set of molecules representative of the different type IV hypersensitivity reactions was evaluated in the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd1b0cb8fb7c7bb5c2b1e17d9fb39d86
https://doi.org/10.1128/spectrum.01357-22
https://doi.org/10.1128/spectrum.01357-22
Autor:
Susana A. Laucella, Jacqueline Bua, Myriam Nuñez, María Cecilia Albareda, María G. Álvarez, Graciela Bertocchi, María Ailén Natale, Melisa D. Castro Eiro, Huifeng Shen, Gonzalo Cesar, Rodolfo Viotti, Rick L. Tarleton, Bruno Lococo
Publikováno v:
J Antimicrob Chemother
BackgroundInterruption of benznidazole therapy due to the appearance of adverse effects, which is presumed to lead to treatment failure, is a major drawback in the treatment of chronic Chagas disease.MethodsTrypanosoma cruzi-specific humoral and T ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eab49268619cfc06116fb34ae29f65ba
https://doi.org/10.1093/jac/dkab054
https://doi.org/10.1093/jac/dkab054
Autor:
Thijs J Schrama, Danique A. Laport, Caoimhe H. Kiernan, Manzhi Zhao, Bart J. A. Rijnders, Casper Rokx, Sebastiaan Van Bockstael, Maria C. Jaimes, Ling Li, Dwin G.B. Grashof, Christos A. Ouzounis, Merel E. P. Wilmsen, Daniel Alvarez de la Sierra, Harmen J.G. van de Werken, Tamara van Wees, Inge Brouwers-Haspels, Manuel Hernández-González, Melisa D. Castro Eiro, Marco W.J. Schreurs, Marjan van Meurs, Geoffrey Kraker, Yvonne M. Mueller, Ricardo Pujol-Borrell, Peter D. Katsikis, Harm de Wit, Rik Ruijten, Tessa Alofs
Quantitative or qualitative differences in immunity may drive and predict clinical severity in COVID-19. We therefore measured modules of serum pro-inflammatory, anti-inflammatory and anti-viral cytokines in combination with the anti-SARS-CoV-2 antib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ee7016575b8d7f20a18e3f8667441e0
https://doi.org/10.1101/2021.05.07.21256531
https://doi.org/10.1101/2021.05.07.21256531
Autor:
María Belén Caputo, Graciela Bertocchi, Melisa D. Castro Eiro, Bruno Lococo, María Ailén Natale, María Cecilia Albareda, Susana A. Laucella, Todd Minning, María Gabriela Alvarez, Rick L. Tarleton, Gonzalo Cesar, María Josefina Elias
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 6, p e0009473 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 6, p e0009473 (2021)
In chronic Chagas disease, Trypanosoma cruzi-specific T-cell function decreases over time, and alterations in the homeostatic IL-7/IL-7R axis are evident, consistent with a process of immune exhaustion. IL-27 is an important immunoregulatory cytokine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::577af7362bfe7762687290d509b0970a
https://pubmed.ncbi.nlm.nih.gov/34061845
https://pubmed.ncbi.nlm.nih.gov/34061845