Efficacy of oseltamivir treatment in influenza virus-infected obese mice.

Autor: Honce R; Department of Infectious Diseases, St. Jude Children's Research Hospital , Memphis, Tennessee, USA.; Integrated Program in Biomedical Sciences, University of Tennessee Health Science Center , Memphis, Tennessee, USA., Jones J; Department of Infectious Diseases, St. Jude Children's Research Hospital , Memphis, Tennessee, USA., Meliopoulos VA; Department of Infectious Diseases, St. Jude Children's Research Hospital , Memphis, Tennessee, USA., Livingston B; Department of Infectious Diseases, St. Jude Children's Research Hospital , Memphis, Tennessee, USA., Sharp B; Department of Infectious Diseases, St. Jude Children's Research Hospital , Memphis, Tennessee, USA., Estrada LD; Department of Infectious Diseases, St. Jude Children's Research Hospital , Memphis, Tennessee, USA., Wang L; Preclinical Pharmacokinetic Shared Resource, St. Jude Children's Research Hospital , Memphis, Tennessee, USA., Caulfield W; Preclinical Pharmacokinetic Shared Resource, St. Jude Children's Research Hospital , Memphis, Tennessee, USA., Freeman B; Preclinical Pharmacokinetic Shared Resource, St. Jude Children's Research Hospital , Memphis, Tennessee, USA., Govorkova E; Department of Infectious Diseases, St. Jude Children's Research Hospital , Memphis, Tennessee, USA., Schultz-Cherry S; Department of Infectious Diseases, St. Jude Children's Research Hospital , Memphis, Tennessee, USA.; Integrated Program in Biomedical Sciences, University of Tennessee Health Science Center , Memphis, Tennessee, USA.

Publikováno v: MBio [mBio] 2023 Aug 31; Vol. 14 (4), pp. e0088723. Date of Electronic Publication: 2023 Jun 21.

Defining the risk of SARS-CoV-2 variants on immune protection.

Autor: DeGrace MM; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.; Division of Microbiology and Infectious Diseases, National Institutes of Health, Rockville, MD, USA., Ghedin E; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.; Systems Genomics Section, Laboratory of Parasitic Diseases, National Institutes of Health, Rockville, MD, USA., Frieman MB; Center for Pathogen Research, Department of Microbiology and Immunology, The University of Maryland School of Medicine, Baltimore, MD, USA., Krammer F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. florian.krammer@mssm.edu.; Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. florian.krammer@mssm.edu., Grifoni A; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA., Alisoltani A; University of California Riverside School of Medicine, Riverside, CA, USA., Alter G; Ragon Institute of MGH, MIT, and Harvard, Boston, MA, USA., Amara RR; Department of Microbiology and Immunology, Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, GA, USA., Baric RS; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Microbiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Barouch DH; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA., Bloom JD; Fred Hutch Cancer Center, Howard Hughes Medical Institute, Seattle, WA, USA., Bloyet LM; Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA., Bonenfant G; CDC COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, GA, USA., Boon ACM; Department of Medicine, Washington University in St Louis, St Louis, MO, USA., Boritz EA; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.; Division of Microbiology and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.; Vaccine Research Center, Bethesda, MD, USA., Bratt DL; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.; Division of Microbiology and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.; CAMRIS, Contractor for NIAID, Bethesda, MD, USA., Bricker TL; Department of Medicine, Washington University in St Louis, St Louis, MO, USA., Brown L; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.; Division of Microbiology and Infectious Diseases, National Institutes of Health, Rockville, MD, USA., Buchser WJ; High Throughput Screening Center, Washington University School of Medicine, St Louis, MO, USA., Carreño JM; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Cohen-Lavi L; National Institute for Biotechnology in the Negev, Department of Industrial Engineering and Management, Ben-Gurion University of the Negev, Be'er-Sheva, Israel., Darling TL; Department of Medicine, Washington University in St Louis, St Louis, MO, USA., Davis-Gardner ME; Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta, Department of Pediatrics, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA., Dearlove BL; US Military HIV Research Program, Henry M. Jackson Foundation for the Advancement of Military Medicine, Walter Reed Army Institute of Research, Silver Spring, MD, USA., Di H; CDC COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, GA, USA., Dittmann M; Microbiology Department, New York University Grossman School of Medicine, New York, NY, USA., Doria-Rose NA; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.; Vaccine Research Center, Bethesda, MD, USA., Douek DC; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.; Vaccine Research Center, Bethesda, MD, USA., Drosten C; Institute of Virology, Charité-Universitätsmedizin and German Center for Infection Research (DZIF), Berlin, Germany., Edara VV; Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta, Department of Pediatrics, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA., Ellebedy A; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA., Fabrizio TP; Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, USA., Ferrari G; Department of Surgery, Duke University Medical Center, Durham, NC, USA., Fischer WM; Los Alamos National Laboratory, New Mexico Consortium, Los Alamos, NM, USA., Florence WC; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.; Division of Microbiology and Infectious Diseases, National Institutes of Health, Rockville, MD, USA., Fouchier RAM; Department Viroscience, Erasmus MC, Rotterdam, The Netherlands., Franks J; Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, USA., García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Godzik A; University of California Riverside School of Medicine, Riverside, CA, USA., Gonzalez-Reiche AS; Department of Genetics and Genomic Sciences, Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Gordon A; Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA., Haagmans BL; Department Viroscience, Erasmus MC, Rotterdam, The Netherlands., Halfmann PJ; Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA., Ho DD; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA., Holbrook MR; National Institute of Allergy and Infectious Diseases Integrated Research Facility, Frederick, MD, USA., Huang Y; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA., James SL; Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge, UK., Jaroszewski L; University of California Riverside School of Medicine, Riverside, CA, USA., Jeevan T; Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, USA., Johnson RM; Center for Pathogen Research, Department of Microbiology and Immunology, The University of Maryland School of Medicine, Baltimore, MD, USA., Jones TC; Institute of Virology, Charité-Universitätsmedizin and German Center for Infection Research (DZIF), Berlin, Germany.; Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge, UK., Joshi A; Department of Medicine, Washington University in St Louis, St Louis, MO, USA., Kawaoka Y; Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA.; Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Disease Control and Prevention Center, National Center for Global Health and Medicine Hospital, Tokyo, Japan., Kercher L; Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, USA., Koopmans MPG; Department Viroscience, Erasmus MC, Rotterdam, The Netherlands., Korber B; Los Alamos National Laboratory, New Mexico Consortium, Los Alamos, NM, USA., Koren E; National Institute for Biotechnology in the Negev, Department of Industrial Engineering and Management, Ben-Gurion University of the Negev, Be'er-Sheva, Israel.; The Shraga Segal Department of Microbiology and Immunology, Ben-Gurion University of the Negev, Be'er Sheva, Israel., Koup RA; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.; Vaccine Research Center, Bethesda, MD, USA., LeGresley EB; Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge, UK., Lemieux JE; Broad Institute of MIT and Harvard, Boston, MA, USA., Liebeskind MJ; High Throughput Screening Center, Washington University School of Medicine, St Louis, MO, USA., Liu Z; Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA., Livingston B; Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, USA., Logue JP; Center for Pathogen Research, Department of Microbiology and Immunology, The University of Maryland School of Medicine, Baltimore, MD, USA., Luo Y; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA., McDermott AB; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.; Vaccine Research Center, Bethesda, MD, USA., McElrath MJ; Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Meliopoulos VA; Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, USA., Menachery VD; Department of Microbiology and Immunology, Institute for Human Infection and Immunity, World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX, USA., Montefiori DC; Duke University Medical Center, Durham, NC, USA., Mühlemann B; Institute of Virology, Charité-Universitätsmedizin and German Center for Infection Research (DZIF), Berlin, Germany.; Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge, UK., Munster VJ; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA., Munt JE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Nair MS; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA., Netzl A; Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge, UK., Niewiadomska AM; Department of Informatics, J. Craig Venter Institute, La Jolla, CA, USA., O'Dell S; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.; Vaccine Research Center, Bethesda, MD, USA., Pekosz A; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Perlman S; Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA., Pontelli MC; Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA., Rockx B; Department Viroscience, Erasmus MC, Rotterdam, The Netherlands., Rolland M; US Military HIV Research Program, Henry M. Jackson Foundation for the Advancement of Military Medicine, Walter Reed Army Institute of Research, Silver Spring, MD, USA., Rothlauf PW; Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA., Sacharen S; National Institute for Biotechnology in the Negev, Department of Industrial Engineering and Management, Ben-Gurion University of the Negev, Be'er-Sheva, Israel.; The Shraga Segal Department of Microbiology and Immunology, Ben-Gurion University of the Negev, Be'er Sheva, Israel., Scheuermann RH; Department of Informatics, J. Craig Venter Institute, La Jolla, CA, USA., Schmidt SD; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.; Vaccine Research Center, Bethesda, MD, USA., Schotsaert M; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Schultz-Cherry S; Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, USA., Seder RA; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.; Vaccine Research Center, Bethesda, MD, USA., Sedova M; University of California Riverside School of Medicine, Riverside, CA, USA., Sette A; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA.; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA, USA., Shabman RS; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.; Division of Microbiology and Infectious Diseases, National Institutes of Health, Rockville, MD, USA., Shen X; Department of Surgery, Duke University Medical Center, Durham, NC, USA., Shi PY; Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, TX, USA., Shukla M; University of Chicago Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL, USA.; Data Science and Learning Division, Argonne National Laboratory, Argonne, IL, USA., Simon V; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Stumpf S; Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA., Sullivan NJ; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.; Vaccine Research Center, Bethesda, MD, USA., Thackray LB; Department of Medicine, Washington University in St Louis, St Louis, MO, USA., Theiler J; Los Alamos National Laboratory, New Mexico Consortium, Los Alamos, NM, USA., Thomas PG; Department of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA., Trifkovic S; Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, USA., Türeli S; Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge, UK., Turner SA; Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge, UK., Vakaki MA; High Throughput Screening Center, Washington University School of Medicine, St Louis, MO, USA., van Bakel H; Department of Genetics and Genomic Sciences, Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., VanBlargan LA; Department of Medicine, Washington University in St Louis, St Louis, MO, USA., Vincent LR; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.; Division of Microbiology and Infectious Diseases, National Institutes of Health, Rockville, MD, USA., Wallace ZS; Department of Informatics, J. Craig Venter Institute, La Jolla, CA, USA.; Department of Computer Science and Engineering, University of California, San Diego, CA, USA., Wang L; CDC COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, GA, USA., Wang M; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA., Wang P; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA., Wang W; Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA., Weaver SC; Department of Microbiology and Immunology, Institute for Human Infection and Immunity, World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX, USA., Webby RJ; Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, USA., Weiss CD; Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA., Wentworth DE; CDC COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, GA, USA., Weston SM; Center for Pathogen Research, Department of Microbiology and Immunology, The University of Maryland School of Medicine, Baltimore, MD, USA., Whelan SPJ; Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA., Whitener BM; Department of Medicine, Washington University in St Louis, St Louis, MO, USA., Wilks SH; Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge, UK., Xie X; Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, TX, USA., Ying B; Department of Medicine, Washington University in St Louis, St Louis, MO, USA., Yoon H; Los Alamos National Laboratory, New Mexico Consortium, Los Alamos, NM, USA., Zhou B; CDC COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, GA, USA., Hertz T; Department of Microbiology, Immunology and Genetics Faculty of Health Sciences Ben-Gurion University of the Negev, Be'er Sheva, Israel. thertz@bgu.ac.il., Smith DJ; Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge, UK. djs200@cam.ac.uk., Diamond MS; Department of Medicine, Washington University in St Louis, St Louis, MO, USA. mdiamond@wustl.edu.; Department of Pathology & Immunology, Washington University School of Medicine, St Louis, MO, USA. mdiamond@wustl.edu.; Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA. mdiamond@wustl.edu.; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St Louis, MO, USA. mdiamond@wustl.edu., Post DJ; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA. postd@niaid.nih.gov.; Division of Microbiology and Infectious Diseases, National Institutes of Health, Rockville, MD, USA. postd@niaid.nih.gov., Suthar MS; Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta, Department of Pediatrics, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA. mehul.s.suthar@emory.edu.

Publikováno v: Nature [Nature] 2022 May; Vol. 605 (7911), pp. 640-652. Date of Electronic Publication: 2022 Mar 31.

Influenza in High-Risk Hosts-Lessons Learned from Animal Models.

Autor: Honce R; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-3678, USA.; Integrated Program in Biomedical Sciences, Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA., Wohlgemuth N; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-3678, USA., Meliopoulos VA; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-3678, USA., Short KR; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia., Schultz-Cherry S; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-3678, USA.

Publikováno v: Cold Spring Harbor perspectives in medicine [Cold Spring Harb Perspect Med] 2020 Dec 01; Vol. 10 (12). Date of Electronic Publication: 2020 Dec 01.

Obesity-Related Microenvironment Promotes Emergence of Virulent Influenza Virus Strains.

Autor: Honce R; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.; Integrated Biomedical Sciences Program, University of Tennessee Health Science Center, Memphis, Tennessee, USA., Karlsson EA; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Wohlgemuth N; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Estrada LD; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Meliopoulos VA; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Yao J; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Schultz-Cherry S; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA stacey.schultz-cherry@stjude.org.

Publikováno v: MBio [mBio] 2020 Mar 03; Vol. 11 (2). Date of Electronic Publication: 2020 Mar 03.

Although it's painful: The importance of stringent antibody validation.

Autor: Meliopoulos VA; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America., Schultz-Cherry S; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.

Publikováno v: PLoS pathogens [PLoS Pathog] 2018 Jan 04; Vol. 14 (1), pp. e1006701. Date of Electronic Publication: 2018 Jan 04 (Print Publication: 2018).