Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Melinda Y, Hardy"'
Autor:
Olivia G. Moscatelli, Amy K. Russell, Lee M. Henneken, Melinda Y. Hardy, Nadia Mazarakis, Rachel Higgins, Jesse Ekin, Harry McLeod, Paul Simkin, Paul V. Licciardi, Vanessa L. Bryant, Jason A. Tye-Din
Publikováno v:
Vaccines, Vol 12, Iss 2, p 214 (2024)
Coeliac disease (CD) is associated with hyposplenism, an acquired impairment of spleen function associated with reduced IgM memory B cells and increased susceptibility to serious pneumococcal infection. Little is known about the immune implications o
Externí odkaz:
https://doaj.org/article/e17c41d4d0be4987a969999799474973
Autor:
Man Lyang Kim, Melinda Y. Hardy, Laura E. Edgington-Mitchell, Sri H. Ramarathinam, Shan Zou Chung, Amy K. Russell, Iain Currie, Brad E. Sleebs, Anthony W. Purcell, Jason A. Tye-Din, Ian P. Wicks
Publikováno v:
iScience, Vol 24, Iss 12, Pp 103509- (2021)
Summary: Although hydroxychloroquine (HCQ) has long been used to treat autoimmune diseases, its mechanism of action remains poorly understood. In CD4 T-cells, we found that a clinically relevant concentration of HCQ inhibited the mitochondrial antiox
Externí odkaz:
https://doaj.org/article/b4f7fa75e9d149f7bbd861a7d084ca17
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/ea7521c7d1e545cbb9d9c934070771fd
Autor:
Melinda Y. Hardy, Gautam Goel, Amy K. Russell, Swee Lin G. Chen Yi Mei, Gregor J. E. Brown, Suyue Wang, Evan Szymczak, Ruan Zhang, Kaela E. Goldstein, Kristin M. Neff, Leslie J. Williams, Kenneth E. Truitt, John L. Dzuris, Jason A. Tye-Din, Robert P. Anderson
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Improved blood tests assessing the functional status of rare gluten-specific CD4+ T cells are needed to effectively monitor experimental therapies for coeliac disease (CD). Our aim was to develop a simple, but highly sensitive cytokine release assay
Externí odkaz:
https://doaj.org/article/44d464c9335848cca3a691f2d2a3caa2
Autor:
Laura Cook, C Mee Ling Munier, Nabila Seddiki, Melinda Y Hardy, Robert P Anderson, John Zaunders, Jason A Tye‐Din, Anthony D Kelleher, David vanBockel
Publikováno v:
Clinical & Translational Immunology, Vol 9, Iss 1, Pp n/a-n/a (2020)
Abstract Objectives Understanding the T cell receptor (TCR) repertoire of regulatory CD4+ T‐cell (Treg) populations is important for strategies aiming to re‐establish tolerance in autoimmune diseases. We studied circulating deamidated gluten‐ep
Externí odkaz:
https://doaj.org/article/f49762ba1fe84680a9b4f0f74a8f9b63
Autor:
Greg Tanner, Angéla Juhász, Christakis George Florides, Mitchell Nye-Wood, Frank Békés, Michelle L. Colgrave, Amy K. Russell, Melinda Y. Hardy, Jason A. Tye-Din
Publikováno v:
Frontiers in Nutrition, Vol 6 (2019)
The safety of oats for people with celiac disease remains unresolved. While oats have attractive nutritional properties that can improve the quality and palatability of the restrictive, low fiber gluten-free diet, rigorous feeding studies to address
Externí odkaz:
https://doaj.org/article/25c171019c6f4f20a44cd7c4ebb4b93d
Autor:
Jan Petersen, Hugh H. Reid, Laura Ciacchi, Melinda Y Hardy, Frits Koning, Robert P. Anderson, Khai Lee Loh, Yvonne Kooy-Winkelaar, Jason A. Tye-Din, Anthony W. Purcell, Zhenjun Chen, Jamie Rossjohn, James McCluskey, Mai T. Tran, Nathan P. Croft
Publikováno v:
Nature Structural and Molecular Biology. NATURE PUBLISHING GROUP
Nature Structural and Molecular Biology
Nature Structural and Molecular Biology
Structural, biochemical and cellular analyses show that bacterial antigens can mimic gliadin epitopes involved in celiac disease being presented by HLA-DQ2.5 and recognized by T cells derived from patients.The human leukocyte antigen (HLA) locus is s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3abfd599d8b19bafaf0dfa39cb73754c
https://doi.org/10.1038/s41594-019-0353-4
https://doi.org/10.1038/s41594-019-0353-4
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eda615d87c140dcdd3624afccd53c05
https://www.frontiersin.org/articles/10.3389/fimmu.2021.756087/full
https://www.frontiersin.org/articles/10.3389/fimmu.2021.756087/full
Autor:
Shan Zou Chung, Jason A. Tye-Din, Ian P. Wicks, Iain Currie, Sri H. Ramarathinam, Man Lyang Kim, Anthony W. Purcell, Amy K. Russell, Brad E. Sleebs, Laura E. Edgington-Mitchell, Melinda Y Hardy
Publikováno v:
iScience
iScience, Vol 24, Iss 12, Pp 103509-(2021)
iScience, Vol 24, Iss 12, Pp 103509-(2021)
Summary Although hydroxychloroquine (HCQ) has long been used to treat autoimmune diseases, its mechanism of action remains poorly understood. In CD4 T-cells, we found that a clinically relevant concentration of HCQ inhibited the mitochondrial antioxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17feb8ec9d2105f3034b96fd3003b3bc
https://pubmed.ncbi.nlm.nih.gov/34934928
https://pubmed.ncbi.nlm.nih.gov/34934928
Autor:
Gautam Goel, Suyue Wang, Robert P. Anderson, Kaela E. Goldstein, Amy K. Russell, Kristin M Neff, Kenneth E. Truitt, Jason A. Tye-Din, Leslie J. Williams, Ruan Zhang, Evan Szymczak, John L. Dzuris, Melinda Y Hardy
Publikováno v:
Clin Exp Immunol
Summary Whole blood cytokine release assays (CRA) assessing cellular immunity to gluten could simplify the diagnosis and monitoring of coeliac disease (CD). We aimed to determine the effectiveness of electrochemiluminescence CRA to detect responses t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c270b7233ff489affb62588ee0ab3b41
https://pubmed.ncbi.nlm.nih.gov/33469922
https://pubmed.ncbi.nlm.nih.gov/33469922