Výsledky vyhledávání - "Melinda Sipos"

Targeting NOX2 via p47/phox-p22/phox Inhibition with Novel Triproline Mimetics

Autor: Jean-Baptiste Garsi, Balázs Komjáti, Gregorio Cullia, Imre Fejes, Melinda Sipos, Zoltán Sipos, Eszter Fördős, Piroska Markacz, Barbara Balázs, Nathalie Lancelot, Sylvie Berger, Eric Raimbaud, David Brown, Laurent-Michel Vuillard, Laure Haberkorn, Cyprian Cukier, Zoltán Szlávik, Stephen Hanessian

Publikováno v: ACS medicinal chemistry letters, vol 13, iss 6
ACS Med Chem Lett

[Image: see text] On the basis of the knowledge that the proline-rich hot spot PPPRPP region of P(151)PSNPPPRPP(160), an oligopeptide derived from the cytosolic portion of p22(phox) (p22), binds to the single functional bis-SH3 domain of the regulato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa70b14a5bdfbbdfe94d8e9fe7ef2af
https://doi.org/10.1021/acsmedchemlett.2c00094

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Synthesis of cyclic aminomethylphosphonates and aminomethyl-arylphosphinic acids by an efficient microwave-mediated phospha-mannich approach

Autor: Melinda Sipos, István Greiner, Anna Szekrenyi, György Keglevich, Krisztina Ludányi

Publikováno v: Heteroatom Chemistry. 19:207-210

Microwave-assisted condensation of 1,3,-2-dioxaphosphinane 2-oxide (1), paraformaldehyde and secondary amines including 5- and 6-membered N-heterocycles at 55°C gave cyclic aminomethylphosphonates (2), whereas an analogous reaction involving dibenzo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac5c7c5b177b3f0b3208a1e7b35a9a81
https://doi.org/10.1002/hc.20387

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Phospha-michael reactions involving p-heterocyclic nucleophiles

Autor: György Keglevich, Krisztina Ludányi, Daniella Takács, Melinda Sipos

Publikováno v: Heteroatom Chemistry. 19:288-292

P-heterocyclic γ-ketophosphonates were synthesized by the Michael reaction of methyl vinyl ketone with dibenzo-1,2-oxaphosphorine 2-oxide, 1,3,2-dioxaphosphorine 2-oxide and benzo-1,3,2-dioxaphospholane 2-oxide, respectively. In the first two cases,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24779549f935c6452662b86512a0fba5
https://doi.org/10.1002/hc.20421

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A study on the michael addition of dialkylphosphites to methylvinylketone

Autor: György Keglevich, Melinda Sipos, Daniella Takács, István Greiner

Publikováno v: Heteroatom Chemistry. 18:226-229

The addition of dialkylphosphites to methylvinylketone giving dialkyl-3-oxobutylphos- phonates was studied applying different reagents, such as NaOR/ROH, NaOH/H2O under PTC, DBU, and R3Al (R = Me, Et) under different conditions to find the optimum ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f2416fb5c3512e097a5a435e91e04412
https://doi.org/10.1002/hc.20266

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Intra- and intermolecular interactions and water pincer in the crystal structure of a 3-P(O)Ph2substituted 1,2,3,6-tetrahydrophosphinine oxide hydrate

Autor: Mátyás Czugler, György Keglevich, Melinda Sipos, Tamás Körtvélyesi, László Fábián

Publikováno v: CrystEngComm. 9:561-565

Single crystal X-ray structure analysis of 3-diphenylphosphinoxido-1-phenyl-4-chloro-1,2,3,6-tetrahydrophosphinine oxide (1)·H2O provided experimental proof for a transannular PO⋯HC type interaction. The embedded water molecule bridges two PO grou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0dd6d3282de40d824c01cf9846caddc0
https://doi.org/10.1039/b702137b

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1,2,3,4,5,6-Hexahydrophosphinine 1-oxides with an exocyclic P-function at position 3: diastereoselective synthesis, stereostructure and conformation

Autor: Tímea Imre, György Keglevich, László Tőke, Melinda Sipos, Tamás Körtvélyesi

Publikováno v: Tetrahedron Letters. 46:1655-1658

Catalytic hydrogenation of the corresponding tetrahydrophosphinine oxides afforded the title compounds (4–6) as exclusive or major diastereomers the stereostructure and conformation of which were evaluated by stereospecific 3J couplings, as well as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::328585d635d977119a2043bccf84d825
https://doi.org/10.1016/j.tetlet.2005.01.073

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A theoretical study on the conformation of 3-phosphinoxido- and 3-phosphono-1,2,3,4,5,6-hexahydrophosphinine 1-oxides

Autor: Melinda Sipos, Tamás Körtvélyesi, György Keglevich

Publikováno v: Heteroatom Chemistry. 16:520-524

The title compounds (2 and 4) obtained by the diastereoselective hydrogenation of the corresponding 1,2,3,6-tetrahydrophosphinine oxides (1 and 3) were subjected to a detailed quantum chemical study. The possible chair conformers were calculated at t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::819c88fd328cd6ae4a00e949c229a839
https://doi.org/10.1002/hc.20148

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4-Chloro-5-methyl-3-diphenylphosphino-1-phenyl-1,2,3,6-tetrahydrophosphinine as a bidentate P-ligand in a cis chelate Pt(II) complex

Autor: Dénes Szieberth, György Keglevich, László Kollár, Melinda Sipos, György Petőcz

Publikováno v: Journal of Organometallic Chemistry. 689:3158-3162

Double deoxygenation of a 3-phosphinoxido-1,2,3,6-tetrahydrophosphine oxide ( 2 ) led to bisphosphine 3 – 2 with an inverted ring P atom. The reaction of bidentate P-ligand 3 – 2 with dichlorodibenzonitrilo platinum(II) yielded the mixture of a n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::435475213c8048f62d661f003ac43550
https://doi.org/10.1016/j.jorganchem.2004.06.062

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Diastereoselective synthesis of 1,2,3,6-tetrahydrophosphinine 1-oxides with an exocyclic P-function by a Michael type addition

Autor: Melinda Sipos, László Tőke, Krisztina Ludányi, Tímea Imre, Dénes Szieberth, György Keglevich

Publikováno v: Tetrahedron Letters. 43:8515-8518

The anions generated from diphenylphosphine oxide or dialkyl phosphites add easily at the α,β-double-bond of 1,2-dihydrophosphinine oxides 1 to afford a single diastereomer of 3-substituted tetrahydrophosphinine oxides 2–4 existing in a twist-boa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f145c65be666fc994aac1f3a08e33491
https://doi.org/10.1016/s0040-4039(02)02081-6

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