Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Melinda S Prucha"'
Autor:
Tanut Kunkanjanawan, Richard L Carter, Melinda S Prucha, Jinjing Yang, Rangsun Parnpai, Anthony W S Chan
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162788 (2016)
Huntington's disease (HD) is an inherited neurodegenerative disorder caused by the expansion of polyglutamine (polyQ) tract that leads to motor, cognitive and psychiatric impairment. Currently there is no cure for HD. A transgenic HD nonhuman primate
Externí odkaz:
https://doaj.org/article/eedcc3583f1d4115b1478abe69f7b57f
Autor:
Anthony W S Chan, Jie Jiang, Yiju Chen, Chunxia Li, Melinda S Prucha, Yijuan Hu, Tim Chi, Sean Moran, Tayeb Rahim, Shihua Li, Xiaojiang Li, Stuart M Zola, Claudia M Testa, Hui Mao, Rosa Villalba, Yoland Smith, Xiaodong Zhang, Jocelyne Bachevalier
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0122335 (2015)
One of the roadblocks to developing effective therapeutics for Huntington disease (HD) is the lack of animal models that develop progressive clinical traits comparable to those seen in patients. Here we report a longitudinal study that encompasses co
Externí odkaz:
https://doaj.org/article/e416b6c611374cee97ca7a70bf7d021c
Autor:
Christopher J Martyniuk, Melinda S Prucha, Nicholas J Doperalski, Philipp Antczak, Kevin J Kroll, Francesco Falciani, David S Barber, Nancy D Denslow
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59093 (2013)
Oocyte maturation in fish involves numerous cell signaling cascades that are activated or inhibited during specific stages of oocyte development. The objectives of this study were to characterize molecular pathways and temporal gene expression patter
Externí odkaz:
https://doaj.org/article/a7f72f3651394754a8c0540116ac11d9
Autor:
Nicholas J. Doperalski, Nancy D. Denslow, Kevin J. Kroll, Melinda S. Prucha, David S. Barber, Christopher J. Martyniuk
Publikováno v:
Gen Comp Endocrinol
Estrogenic contaminants in the environment are linked to the occurrence of reproductive abnormalities in many aquatic species, including largemouth bass (Micropterus salmoides; LMB). Previous work has shown that many different types of xenoestrogens
Autor:
David S. Barber, Candice M. Lavelle, Chris D. Vulpe, Nancy D. Denslow, Reyna Cristina Colli-Dula, Kevin J. Kroll, Melinda S. Prucha, Alvine C. Mehinto
Publikováno v:
Aquatic Toxicology. 152:186-194
Cadmium is a heavy metal that can accumulate to toxic levels in the environment leading to detrimental effects in animals and humans including kidney, liver and lung injuries. Using a transcriptomics approach, genes and cellular pathways affected by
Autor:
Richard Carter, Tanut Kunkanjanawan, Jinjing Yang, Rangsun Parnpai, Anthony W.S. Chan, Melinda S. Prucha
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 9, p e0162788 (2016)
PLoS ONE, Vol 11, Iss 9, p e0162788 (2016)
Huntington’s disease (HD) is an inherited neurodegenerative disorder caused by the expansion of polyglutamine (polyQ) tract that leads to motor, cognitive and psychiatric impairment. Currently there is no cure for HD. A transgenic HD nonhuman prima
Autor:
April Feswick, Christopher J. Martyniuk, Nancy D. Denslow, Melinda S. Prucha, Nicholas J. Doperalski, David S. Barber, Kevin J. Kroll
Publikováno v:
Aquatic toxicology (Amsterdam, Netherlands). 177
Largemouth bass (Micropterus salmoides) inhabiting Lake Apopka, Florida are exposed to high levels of persistent organochlorine pesticides (OCPs) and dietary uptake is a significant route of exposure for these apex predators. The objectives of this s
Autor:
David S. Barber, Nicholas J. Doperalski, Roxanne Conrow, Christopher J. Martyniuk, Melinda S. Prucha, Nancy D. Denslow, Kevin J. Kroll, Jiliang Zhang
Publikováno v:
Comparative biochemistry and physiology. Part D, Genomicsproteomics. 19
Lake Apopka (FL, USA) has elevated levels of some organochlorine pesticides in its sediments and a portion of its watershed has been designated a US Environmental Protection Agency Superfund site. This study assessed reproductive endpoints in Florida
Autor:
Sherrie Jean, Melinda S. Prucha, Sean P. Moran, Kenneth G. Gould, Kwang Sung Ahn, Tim Chi, Anthony W.S. Chan, Fawn Connor-Stroud
Transgenic nonhuman primate models are increasingly popular model for neurological and neurodegenerative disease because their brain functions and neural anatomies closely resemble those of humans [1–6]. Transgenic Huntington’s disease monkeys (H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::210afc42c25e72b8efcb6aba93f5bd06
https://europepmc.org/articles/PMC4631054/
https://europepmc.org/articles/PMC4631054/
Autor:
Stuart M. Zola, Jocelyne Bachevalier, Anthony W.S. Chan, Claudia M. Testa, Sean P. Moran, Hui Mao, Melinda S. Prucha, Tayeb Rahim, Chun-Xia Li, Yi-Juan Hu, Rosa M. Villalba, Shihua Li, Jie Jiang, Xiaodong Zhang, Yiju Chen, Tim Chi, Xiao-Jiang Li, Yoland Smith
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 5, p e0122335 (2015)
PLoS ONE, Vol 10, Iss 5, p e0122335 (2015)
One of the roadblocks to developing effective therapeutics for Huntington disease (HD) is the lack of animal models that develop progressive clinical traits comparable to those seen in patients. Here we report a longitudinal study that encompasses co