Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Melinda M, Parnell"'
Autor:
Peter D. Larsen, Melinda M. Parnell
Publikováno v:
Resuscitation. 73:271-278
Summary Recent studies have found that poor cardiopulmonary resuscitation (CPR) is commonly performed in resuscitation attempts, both by health professionals and lay people. One of the contributing factors to poor performance of CPR may be poor initi
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 287:H395-H400
Whereas l-arginine is clearly recognized as the precursor for nitric oxide synthesis, and its entry into endothelial cells via system y+ transport is established, few data exist regarding the acute regulation of this transport process. We specificall
Publikováno v:
British Journal of Clinical Pharmacology. 55:212-215
Aims As statin therapy has been demonstrated to augment endothelial function in sedentary hypercholesterolaemia (HC), we aimed to investigate the effects of atorvastatin therapy on endothelial function in physically active, HC men. Method and results
Publikováno v:
Clinical Science. 102:1-7
Systemic arterial compliance (SAC) makes an important contribution to cardiac afterload, and thus is a significant determinant of left ventricular work. Previous studies have suggested that arterial compliance may be reduced in patients with congesti
Publikováno v:
Clinical science (London, England : 1979). 109(6)
We have reported previously a decrease in the clearance of the NO (nitric oxide) precursor L-arginine in the forearm circulation of CHF (congestive heart failure) patients, suggesting a potential rate-limiting mechanism contributing to the common fin
Autor:
Tanneale Marshall, Wei-Zheng Zhang, Samara Finch, Melinda M. Parnell, Markus P. Schlaich, David M. Kaye, Belinda A. Ahlers
Publikováno v:
Circulation. 110(24)
Background— Impaired endothelium-dependent NO-mediated vasodilation is a key feature of essential hypertension and may precede the increase in blood pressure. We investigated whether transport of the NO precursor l -arginine is related to decreased
Publikováno v:
Journal of hypertension. 22(10)
BACKGROUND It is unknown whether beta-adrenoceptor-mediated vasodilatation is altered in early hypertension and whether it can be modulated by L-arginine. METHODS AND DESIGN We measured changes in forearm blood flow by plethysmography in response to
Publikováno v:
Journal of hypertension. 22(2)
OBJECTIVES Endothelial dysfunction is established in aged individuals; however, the mechanism(s) are not fully elucidated. We have previously identified l-arginine transport as a potential rate-limiting factor in nitric oxide (NO) production in heart
Publikováno v:
British journal of clinical pharmacology. 55(2)
As statin therapy has been demonstrated to augment endothelial function in sedentary hypercholesterolaemia (HC), we aimed to investigate the effects of atorvastatin therapy on endothelial function in physically active, HC men.Eleven physically active
Publikováno v:
Circulation research. 91(12)
Altered nitric oxide (NO) bioavailability has been ascribed an important role in the pathophysiology of congestive heart failure (CHF). In the peripheral vasculature, we recently demonstrated a depression ofl-arginine transport in association with ph