Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Melinda M, Mulvihill"'
Publikováno v:
Analytical Chemistry. 95:3779-3788
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1aa6b5c1c7ccbf35008606791d495ae1
https://doi.org/10.1021/acs.analchem.2c04967
https://doi.org/10.1021/acs.analchem.2c04967
Autor:
Ke Sherry Li, John G. Quinn, Matthew J. Saabye, Jesus F. Salcido Guerrero, Jim Nonomiya, Qihui Lian, Wilson Phung, Yevgeniy Izrayelit, Benjamin T. Walters, Amy Gustafson, Nicholas F. Endres, Maureen H. Beresini, Melinda M. Mulvihill
Publikováno v:
Analytical Chemistry. 94:1230-1239
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29bfe968fd4881356fdca488b3f19009
https://doi.org/10.1021/acs.analchem.1c04463
https://doi.org/10.1021/acs.analchem.1c04463
Autor:
Christopher W. Davies, Angela J. Oh, Rana Mroue, Micah Steffek, John M. Bruning, Yang Xiao, Siyu Feng, Sangeeta Jayakar, Emily Chan, Vidhyalakshmi Arumugam, Sean Carlo Uribe, Jake Drummond, Alexandra Frommlet, Cheng Lu, Yvonne Franke, Mark Merchant, Hartmut Koeppen, John G. Quinn, Sushant Malhotra, Steve Do, Lewis Gazzard, Hans E. Purkey, Joachim Rudolph, Melinda M. Mulvihill, James T. Koerber, Weiru Wang, Marie Evangelista
Publikováno v:
Nature Biotechnology. 40:769-778
Small molecules that stabilize inactive protein conformations are an underutilized strategy for drugging dynamic or otherwise intractable proteins. To facilitate the discovery and characterization of such inhibitors, we created a screening platform t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35e7535a8c00892ca54049569e89a81c
https://doi.org/10.1038/s41587-021-01126-9
https://doi.org/10.1038/s41587-021-01126-9
Autor:
Micah Steffek, Elizabeth Helgason, Nataliya Popovych, Lionel Rougé, John M. Bruning, Ke Sherry Li, Daniel J. Burdick, Jianping Cai, Terry Crawford, Jing Xue, Willy Decurtins, Chunlin Fang, Felix Grubers, Michael J. Holliday, Allyson Langley, Ann Petersen, Alexander Lee Satz, Aimin Song, Daniel Stoffler, Quentin Strebel, Jeffrey Y. K. Tom, Nicholas Skelton, Steven T. Staben, Moreno Wichert, Melinda M. Mulvihill, Erin C. Dueber
Publikováno v:
Biochemistry. 62:633-644
Autophagy-related proteins (Atgs) drive the lysosome-mediated degradation pathway, autophagy, to enable the clearance of dysfunctional cellular components and maintain homeostasis. In humans, this process is driven by the mammalian Atg8 (mAtg8) famil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61c00ab7c9a5fb6957dbd609eeeeb525
https://doi.org/10.1021/acs.biochem.1c00682
https://doi.org/10.1021/acs.biochem.1c00682
Autor:
Wayne J. Fairbrother, Sayumi Yamazoe, Ingrid E. Wertz, Nicole Blaquiere, Steven T. Staben, Willem den Besten, Domagoj Vucic, Kebing Yu, Melinda M. Mulvihill, Elizabeth Helgason, Erin C. Dueber, Kshitij Verma, Wilson Phung, Tatiana Goncharov, Sumit Prakash, Anita Izrael-Tomasevic
Publikováno v:
Journal of the American Chemical Society. 143:10571-10575
We hypothesized that the proximity-driven ubiquitylation of E3-interacting small molecules could affect the degradation of E3 ubiquitin ligases. A series of XIAP BIR2 domain-binding small molecules was modified to append a nucleophilic primary amine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8f843d2ea05f107972c8984483e27ea
https://doi.org/10.1021/jacs.1c05269
https://doi.org/10.1021/jacs.1c05269
Publikováno v:
Chemmedchem
PROteolysis TArgeting Chimeras (PROTACs) promote the degradation, rather than inhibition, of a drug target as a mechanism for therapeutic treatment. Bifunctional PROTAC molecules allow simultaneous binding of both the target protein and an E3‐Ubiqu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::438a531a32cd145a5fe63df6349ec1d3
http://europepmc.org/articles/PMC8359942
http://europepmc.org/articles/PMC8359942
Autor:
Peter S. Dragovich, Mingtao He, Leanna Staben, Hongyan Zhang, Melinda M. Mulvihill, Catherine Wilson, Hao Zhou, Tracy Kleinheinz, Binqing Wei, Jianfeng Xin, Nicole Blaquiere, Fanwei Meng, John S. Wai, Susan Kaufman, Liang Liu, Rebecca K. Rowntree, Steven T. Staben, Jing Wang, Katherine R. Kozak, Josefa dela Cruz-Chuh, Zijin Xu, Steven J. Hartman, Robert A. Blake, Xiaoyu Zhu, Sunil Bhakta, Donglu Zhang, Hui Yao, Aimee O'Donohue, Jack Sadowsky, Qi Liu, Pragya Adhikari, Liling Liu, Ying Lu, Thomas H. Pillow, Jinhua Chen, Emel Adaligil, Karen E. Gascoigne
Publikováno v:
Journal of Medicinal Chemistry. 64:2534-2575
The biological and medicinal impacts of proteolysis-targeting chimeras (PROTACs) and related chimeric molecules that effect intracellular degradation of target proteins via ubiquitin ligase-mediated ubiquitination continue to grow. However, these chi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eaea12dee6f95904b15f4c9e925d0b1
https://doi.org/10.1021/acs.jmedchem.0c01845
https://doi.org/10.1021/acs.jmedchem.0c01845
Autor:
Peter S. Dragovich, Wolfgang Haap, Melinda M. Mulvihill, Jean-Marc Plancher, Antonia F. Stepan
Publikováno v:
Journal of medicinal chemistry. 65(4)
The origin of small-molecule leads that were pursued across the independent research organizations Roche and Genentech from 2009 to 2020 is described. The identified chemical series are derived from a variety of lead-finding methods, which include pu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5473f4c9b7a73a4ae6fa4a83d3720f9
https://pubmed.ncbi.nlm.nih.gov/35138850
https://pubmed.ncbi.nlm.nih.gov/35138850
Autor:
Ke Sherry, Li, John G, Quinn, Matthew J, Saabye, Jesus F Salcido, Guerrero, Jim, Nonomiya, Qihui, Lian, Wilson, Phung, Yevgeniy, Izrayelit, Benjamin T, Walters, Amy, Gustafson, Nicholas F, Endres, Maureen H, Beresini, Melinda M, Mulvihill
Publikováno v:
Analytical chemistry. 94(2)
With recent advances and success in several drugs designed to treat acute and chronic diseases, targeted covalent inhibitors show a resurgence in drug discovery. As covalent inhibition is time-dependent, the preferred quantitative potency metric of i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3c6f56e996bbec3f30f0c5afa4d4d7f7
https://pubmed.ncbi.nlm.nih.gov/34990117
https://pubmed.ncbi.nlm.nih.gov/34990117
Autor:
Steven J. Hartman, Ying Lu, Wentao Wei, Hao Zhou, Geoffrey Del Rosario, Robert A. Blake, Xiaoyu Zhu, Nicholas Corr, Aaron Fullerton, Shang-Fan Yu, Peter S. Dragovich, Jing Wang, Rebecca K. Rowntree, Donglu Zhang, Hui Yao, Emel Adaligil, Fan Jiang, Hongyan Zhang, Jack Sadowsky, John S. Wai, Jinhua Chen, Thomas H. Pillow, Susan Kaufman, Zijin Xu, Katherine R. Kozak, Jeremy Murray, Shenhua Zhang, Leanna Staben, Josefa dela Cruz-Chuh, Pragya Adhikari, Aimee O'Donohue, Tracy Kleinheinz, Liling Liu, Melinda M. Mulvihill, William S. Sawyer, Yongxin Zhao, Binqing Wei
Publikováno v:
Journal of medicinal chemistry. 64(5)
Heterobifunctional compounds that direct the ubiquitination of intracellular proteins in a targeted manner via co-opted ubiquitin ligases have enormous potential to transform the field of medicinal chemistry. These chimeric molecules, often termed pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::519ca8bb4de4ed4b24ce14fe281e518e
https://pubmed.ncbi.nlm.nih.gov/33596073
https://pubmed.ncbi.nlm.nih.gov/33596073