Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Melinda Larsen"'
Autor:
Bhavik Vyas, Ana Khatiashvili, Lisa Galati, Khoa Ngo, Neil Gildener-Leapman, Melinda Larsen, Igor K. Lednev
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Sjögren's disease is an autoimmune disorder affecting exocrine glands, causing dry eyes and mouth and other morbidities. Polypharmacy or a history of radiation to the head and neck can also lead to dry mouth. Sjogren's disease is often unde
Externí odkaz:
https://doaj.org/article/a41c830f442c43d2a8e2f39cb7136724
Autor:
Sujith Chander Reddy Kollampally, Xulang Zhang, Nicholas Moskwa, Deirdre A. Nelson, Susan T. Sharfstein, Melinda Larsen, Yubing Xie
Publikováno v:
Bioengineering, Vol 11, Iss 4, p 375 (2024)
Mesenchymal stromal cells (MSCs) have displayed potential in regenerating organ function due to their anti-fibrotic, anti-inflammatory, and regenerative properties. However, there is a need for delivery systems to enhance MSC retention while maintain
Externí odkaz:
https://doaj.org/article/944303c647804df080d08f457574e870
Autor:
Amber L. Altrieth, Kevin J. O’Keefe, Victoria A. Gellatly, Joey R. Tavarez, Sage M. Feminella, Nicholas L. Moskwa, Carmalena V. Cordi, Judy C. Turrieta, Deirdre A. Nelson, Melinda Larsen
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Fibrosis results from excess extracellular matrix accumulation, which alters normal tissue architecture and impedes function. In the salivary gland, fibrosis can be induced by irradiation treatment for cancer therapy, Sjögren’s Disease, and other
Externí odkaz:
https://doaj.org/article/a0ff6601fb864efd93121addca352b5f
Publikováno v:
Bioengineering, Vol 11, Iss 1, p 28 (2023)
Salivary gland dysfunction affects millions globally, and tissue engineering may provide a promising therapeutic avenue. This review delves into the current state of salivary gland tissue engineering research, starting with a study of normal salivary
Externí odkaz:
https://doaj.org/article/20d47187d74442b3bf05333fae1ba504
Autor:
Kate Tubbesing, Nicholas Moskwa, Ting Chean Khoo, Deirdre A. Nelson, Anna Sharikova, Yunlong Feng, Melinda Larsen, Alexander Khmaladze
Publikováno v:
Cellular & Molecular Biology Letters, Vol 27, Iss 1, Pp 1-20 (2022)
Highlights Salivary gland organoids have unique Raman signatures detectable with a confocal-based Raman imaging approach. Raman signatures can be detected in unlabeled fixed or live organoids. Raman spectral signatures effectively predict organoid ph
Externí odkaz:
https://doaj.org/article/de3de25b2d744678bef839a4530ccb45
Autor:
Renee F Thiemann, Scott Varney, Nicholas Moskwa, John Lamar, Melinda Larsen, Susan E LaFlamme
Publikováno v:
PLoS ONE, Vol 17, Iss 5, p e0268668 (2022)
The salivary gland can be permanently impaired by radiation treatment for head and neck cancers. Efforts at tissue regeneration have focused on saliva-producing acinar cells. However, myoepithelial cells are also critical to gland function, but mecha
Externí odkaz:
https://doaj.org/article/5fecd85dd79840518bd78b140235ca94
Autor:
Matthew Jorgensen, Pujhitha Ramesh, Miriam Toro, Emily Evans, Nicholas Moskwa, Xulang Zhang, Susan T. Sharfstein, Melinda Larsen, Yubing Xie
Publikováno v:
Bioengineering, Vol 9, Iss 1, p 38 (2022)
Understanding the different regulatory functions of epithelial and mesenchymal cell types in salivary gland development and cellular organization is essential for proper organoid formation and salivary gland tissue regeneration. Here, we demonstrate
Externí odkaz:
https://doaj.org/article/d2e6efc7c64c4826881ee6d2baed7ca4
Publikováno v:
Stem Cell Research, Vol 41, Iss , Pp - (2019)
Salisphere-derived adult epithelial cells have been used to improve saliva production of irradiated mouse salivary glands. Importantly, optimization of the cellular composition of salispheres could improve their regenerative capabilities. The Rho Kin
Externí odkaz:
https://doaj.org/article/7fbd961315ee47889f65ae7fd48617a7
Publikováno v:
Biosensors, Vol 4, Iss 1, Pp 18-27 (2014)
The ability to characterize the microscale mechanical properties of biological materials has the potential for great utility in the field of tissue engineering. The development and morphogenesis of mammalian tissues are known to be guided in part by
Externí odkaz:
https://doaj.org/article/89cb800163fc465a932c37f2a05c2ec6
Autor:
Deirdre A. Nelson, Charles Manhardt, Vidya Kamath, Yunxia Sui, Alberto Santamaria-Pang, Ali Can, Musodiq Bello, Alex Corwin, Sean R. Dinn, Michael Lazare, Elise M. Gervais, Sharon J. Sequeira, Sarah B. Peters, Fiona Ginty, Michael J. Gerdes, Melinda Larsen
Publikováno v:
Biology Open, Vol 2, Iss 5, Pp 439-447 (2013)
Summary Epithelial organ morphogenesis involves reciprocal interactions between epithelial and mesenchymal cell types to balance progenitor cell retention and expansion with cell differentiation for evolution of tissue architecture. Underlying subman
Externí odkaz:
https://doaj.org/article/f330b71b1b6944f7b3adfcb8fde714e6