Zobrazeno 1 - 10
of 227
pro vyhledávání: '"Melinda G Hollingshead"'
Autor:
Tony Navas, Thomas D Pfister, Simona Colantonio, Amina Aziz, Lynda Dieckman, Richard G Saul, Jan Kaczmarczyk, Suzanne Borgel, Sergio Y Alcoser, Melinda G Hollingshead, Young H Lee, Donald P Bottaro, Tara Hiltke, Gordon Whiteley, Naoko Takebe, Robert J Kinders, Ralph E Parchment, Joseph E Tomaszewski, James H Doroshow
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0199361 (2018)
The presence of cancer stem cells (CSCs) and the induction of epithelial-to-mesenchymal transition (EMT) in tumors are associated with tumor aggressiveness, metastasis, drug resistance, and poor prognosis, necessitating the development of reagents fo
Externí odkaz:
https://doaj.org/article/f5177b4e279648b6b9d11f4b1381c950
Autor:
Susan D Mertins, Dominic A Scudiero, Melinda G Hollingshead, Raymond D Divelbiss, Michael C Alley, Anne Monks, David G Covell, Karen M Hite, David S Salomon, John E Niederhuber
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57099 (2013)
BACKGROUND: Cancer stem cells (CSC) are thought to be responsible for tumor maintenance and heterogeneity. Bona fide CSC purified from tumor biopsies are limited in supply and this hampers study of CSC biology. Furthermore, purified stem-like CSC sub
Externí odkaz:
https://doaj.org/article/36d4ba16194044c6a39e47c1292af060
Autor:
Vaibhav Saini, Curtis D Hose, Anne Monks, Kunio Nagashima, Bingnan Han, Dianne L Newton, Angelena Millione, Jalpa Shah, Melinda G Hollingshead, Karen M Hite, Mark W Burkett, Rene M Delosh, Thomas E Silvers, Dominic A Scudiero, Robert H Shoemaker
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e41401 (2012)
Recently, there has been renewed interest in the role of tumor stem cells (TSCs) in tumorigenesis, chemoresistance, and relapse of malignant tumors including osteosarcoma. The potential exists to improve osteosarcoma treatment through characterizatio
Externí odkaz:
https://doaj.org/article/4c0c9f3640804c1e875ac9017ea319e6
Autor:
Angelo B. A. Laranjeira, Melinda G. Hollingshead, Dat Nguyen, Robert J. Kinders, James H. Doroshow, Sherry X. Yang
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Role of DNA damage and demethylation on anticancer activity of DNA methyltransferase inhibitors (DNMTi) remains undefined. We report the effects of DNMT1 gene deletion/disruption (DNMT1 −/− ) on anticancer activity of a class of DNMTi in
Externí odkaz:
https://doaj.org/article/22f1c29b81fd48fabfcfb740b7c77fa9
Autor:
James L. Tatum, Joseph D. Kalen, Paula M. Jacobs, Lisa A. Riffle, Amy James, Lai Thang, Chelsea Sanders, Melinda G. Hollingshead, Falguni Basuli, Jianfeng Shi, James H. Doroshow
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-9 (2022)
Abstract Background Several new generation CDK4/6 inhibitors have been developed and approved for breast cancer therapy in combination with endocrine therapeutics. Application of these inhibitors either alone or in combination in other solid tumors h
Externí odkaz:
https://doaj.org/article/46465784a6b3477e8799af95b712413b
Autor:
James L. Tatum, Joseph D. Kalen, Paula M. Jacobs, Lilia V. Ileva, Lisa A. Riffle, Melinda G. Hollingshead, James H. Doroshow
Publikováno v:
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-10 (2019)
Abstract Background Spontaneously metastatic xenograft models of cancer are infrequent and the few that exist are resource intensive. In xenografts, caliper measurements can be used to determine primary tumor burden and response to therapy but in met
Externí odkaz:
https://doaj.org/article/09dff30361274cb3b7fefc3b8df62375
Autor:
Ralph E. Parchment, James H. Doroshow, Robert J. Kinders, John J. Wright, Donald P. Bottaro, James O. Peggins, Melanie A. Simpson, Dane Liston, Joseph M. Covey, Jeevan Prasaad Govindharajulu, Melinda G. Hollingshead, Apurva K. Srivastava
The development of molecularly targeted agents has benefited from use of pharmacodynamic markers to identify “biologically effective doses” (BED) below MTDs, yet this knowledge remains underutilized in selecting dosage regimens and in comparing t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::505a5b903a222864e5ba59e4d5938957
https://doi.org/10.1158/1535-7163.c.6538198.v1
https://doi.org/10.1158/1535-7163.c.6538198.v1
Autor:
Beverly A. Teicher, Melinda G. Hollingshead, Jerry M. Collins, Mark W. Kunkel, Howard Stotler, John Carter, Kyle Georgius, Suzanne Borgel, Sierra N. Hoffman, Guangfei Huang, Vladimir Rudchenko, Omar D. Lopez, Donn G. Wishka, Joel Morris
Supplementary Table T1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::123b556a7309ec2e43107b114cff8139
https://doi.org/10.1158/1535-7163.22522038.v1
https://doi.org/10.1158/1535-7163.22522038.v1
Autor:
Peter Wipf, Rick Gussio, Connor F. McGrath, Melinda G. Hollingshead, James C. Burnett, Joseph M. Salamoun, Ann Hermone, Brian D. Peyser
Mean graph representation of full NCI-60 Log(GI50) results.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f848f9030085744ee0090891f8a2402
https://doi.org/10.1158/1535-7163.22504501
https://doi.org/10.1158/1535-7163.22504501
Autor:
Jerry M. Collins, A. Douglas Kinghorn, Barry R. O'Keefe, Ryan D. Roberts, Yulin Ren, Garima Agarwal, Li Pan, Rulong Shen, Melinda G. Hollingshead, Larry W. Anderson, Jie Huang, Sarah S. Burns, Janet L. Oblinger, Long-Sheng Chang
Supplementary Figures S1-S7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20f01b293f603c87646c57ab3bc17ccf
https://doi.org/10.1158/1535-7163.22519201
https://doi.org/10.1158/1535-7163.22519201