Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Melinda E. Christensen"'
Autor:
Melinda E. Christensen, Brie E. Turner, Laura J. Sinfield, Katarina Kollar, Hannah Cullup, Nigel J. Waterhouse, Derek N.J. Hart, Kerry Atkinson, Alison M. Rice
Publikováno v:
Haematologica, Vol 95, Iss 12 (2010)
Background Multipotent mesenchymal stromal cells suppress T-cell function in vitro, a property that has underpinned their use in treating clinical steroid-refractory graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.
Externí odkaz:
https://doaj.org/article/25b7db5afff046c0b02c613962fc7e6e
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e28018 (2011)
Protease-activated receptor-2 (PAR2) is a G protein coupled receptor (GPCR) activated by proteolytic cleavage of its amino terminal domain by trypsin-like serine proteases. This irreversible activation mechanism leads to rapid receptor desensitizatio
Externí odkaz:
https://doaj.org/article/f2ecd71eee0e488cad866f6eccbae9b5
Publikováno v:
Cold Spring Harbor protocols. 2016(12)
Adenosine triphosphate (ATP) is the main source of energy for metabolism. Mitochondria provide the majority of this ATP by a process known as oxidative phosphorylation. This process involves active transfer of positively charged protons across the mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::374dec1d8ab32c29d96887a8337b4d58
https://pubmed.ncbi.nlm.nih.gov/27934682
https://pubmed.ncbi.nlm.nih.gov/27934682
Autor:
Fawzi Bokhari, Nigel A.J. McMillan, Melanie Murrell, H. Peter Soyer, Graham R. Leggatt, Karin Sedelies, Brian Gabrielli, Zay Yar Oo, Weili Wang, Mushfiq Hassan Shaikh, Melinda E. Christensen, Sora Fallaha, Dubravka Skalamera, Max V. Ranall, Alexander J. Stevenson, Thomas J. Gonda, Madison Kelly, Daniel Clarke, Sara J. McKee, Paul Leo
Publikováno v:
Molecular cancer therapeutics. 14(12)
Human papillomavirus (HPV) is the causative agent in cervical cancer. HPV oncogenes are major drivers of the transformed phenotype, and the cancers remain addicted to these oncogenes. A screen of the human kinome has identified inhibition of Aurora k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6f9123a6b8d8318255b2cc071ad647b
https://pubmed.ncbi.nlm.nih.gov/26516156
https://pubmed.ncbi.nlm.nih.gov/26516156
Autor:
Brooke J. Marfell, Lisa C. Crowley, Melinda E. Christensen, Adrian P. Scott, Nigel J. Waterhouse, Grace Chojnowski, Jeanne A. Boughaba
Publikováno v:
Cold Spring Harbor Protocols. 2016:pdb.top070318
Many cells in the body die at specific times to facilitate healthy development or because they have become old, damaged, or infected. Defects in cells that result in their inappropriate survival or untimely death can negatively impact development or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4704dbece0302fb00796bbc094a9b24e
https://doi.org/10.1101/pdb.top070318
https://doi.org/10.1101/pdb.top070318
Publikováno v:
Cold Spring Harbor Protocols. 2016:pdb.prot087171
Measuring cell death with colorimetric or fluorimetric dyes such as trypan blue and propidium iodide (PI) can provide an accurate measure of the number of dead cells in a population at a specific time; however, these assays cannot be used to distingu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::844fdea1704ac9d53dbf41f888ddcec5
https://doi.org/10.1101/pdb.prot087171
https://doi.org/10.1101/pdb.prot087171
Publikováno v:
Cold Spring Harbor Protocols. 2016:pdb.prot087155
Trypan blue is a colorimetric dye that stains dead cells with a blue color easily observed using light microscopy at low resolution. The staining procedure is rapid and cells can be analyzed within minutes. The number of live (unstained) and dead (bl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c011cc06b55a0f72126ea8a20a130554
https://doi.org/10.1101/pdb.prot087155
https://doi.org/10.1101/pdb.prot087155
Publikováno v:
Methods (San Diego, Calif.). 61(2)
Mitochondria play a pivotal role in life and death of the cell because they produce the majority of energy required for survival and also regulate the intrinsic pathway to apoptosis. The involvement of mitochondria in cell death is generally measured
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d813c0e130691d8a91d33c88ea5025c9
https://pubmed.ncbi.nlm.nih.gov/23545197
https://pubmed.ncbi.nlm.nih.gov/23545197
Autor:
Melinda E. Christensen, Nigel J. Waterhouse, Matthew Mangan, Monica Devi Prakash, Karin A Sedelies, Phillip I. Bird, Catherina H. Bird, Ian S. Harper, Mark J. Smyth
Publikováno v:
Cell death and differentiation. 21(6)
Cytotoxic lymphocytes (CLs) contain lysosome-related organelles (LROs) that perform the normal degradative functions of the lysosome, in addition to storage and release of powerful cytotoxins employed to kill virally infected or abnormal cells. Among
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7250fb79f20636470b8b9ae753428723
https://pubmed.ncbi.nlm.nih.gov/24488096
https://pubmed.ncbi.nlm.nih.gov/24488096
Autor:
Melinda E. Christensen, Yaowu He, John D. Hooper, Andreas Wortmann, John W. Lumley, Nigel J. Waterhouse, MayLa Linn, Pamela M. Pollock
Publikováno v:
Journal of Biological Chemistry
Free to read on publisher website Reciprocal interactions between Src family kinases (SFKs) and focal adhesion kinase (FAK) are critical during changes in cell attachment. Recently it has been recognized that another SFK substrate, CUB-domain-contain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e5b9e7b38e84562b668bd15d40f9c56
https://europepmc.org/articles/PMC3234987/
https://europepmc.org/articles/PMC3234987/
