Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Melinda D. Wu"'
Autor:
Koya Ozawa, William Packwood, Oleg Varlamov, Matthew Muller, Aris Xie, Melinda D. Wu, Rue-Jen Abraham-Fan, José A. López, Jonathan R. Lindner
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 43:1041-1053
Background: In reperfused myocardial infarction, VWF (von Willebrand factor)-mediated platelet adhesion contributes to impaired microvascular reflow and possibly also to postmyocardial infarction inflammation. We hypothesized that postischemic thromb
Autor:
Aubre Gilbert, Bart Moulton, Kris Kumar, Melinda D. Wu, Jonathan R. Lindner, James Hodovan, Sven R. Olson, Matthew D. Wood
Publikováno v:
Blood Adv
Key Points Ponatinib produces a coronary microangiopathy that mimics myocardial infarction and can be detected rapidly by contrast echocardiography. N-acetylcysteine therapy can potentially resolve ischemic complications caused by ponatinib-related m
Publikováno v:
Arterioscler Thromb Vasc Biol
Abnormal expression or function of several classes of kinases contribute to the development of many types of solid and hematologic malignancies. TKs (tyrosine kinases) in particular play a role in tumor growth, metastasis, neovascularization, suppres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d3290cc3a3b822f58978baf81e03430
https://europepmc.org/articles/PMC7770029/
https://europepmc.org/articles/PMC7770029/
Autor:
Yue Qi, Jonathan R. Lindner, Melinda D. Wu, Nima Nabavizadeh, Andy Kaempf, Yiyi Chen, J. Tanyi
Publikováno v:
Radiat Res
The biological response of normal tissue to high-dose radiation treatment remains poorly understood. Alterations to the microenvironment, specifically the microvasculature, have been implicated as a significant contributor to tumoral cytotoxicity. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a46a3c1b697b415e7167f8a2e1b6c98
https://europepmc.org/articles/PMC7370817/
https://europepmc.org/articles/PMC7370817/
Autor:
Weihui Shentu, Koya Ozawa, The Anh Nguyen, Melinda D. Wu, William Packwood, Aris Xie, Matthew A. Muller, Eran Brown, Matthew W. Hagen, José A. López, Jonathan R. Lindner
Publikováno v:
J Am Soc Echocardiogr
Echocardiographic molecular imaging techniques are beginning to be applied to evaluate preclinical efficacy of new drugs. In a large clinical trial, anti-interleukin-1β (IL-1β) immunotherapy reduced atherosclerotic events, yet treatment effects wer
Autor:
Alan N. Schechter, Andrew E. Arai, Jonathan R. Lindner, Gregory J. Kato, Vandana Sachdev, Stanislav Sidenko, Myron A. Waclawiw, Hwaida Hannoush, Melinda D. Wu, Cynthia L. Brenneman, Caterina P. Minniti
Publikováno v:
British Journal of Haematology. 179:648-656
Summary In sickle cell disease (SCD), abnormal microvascular function combined with chronic anaemia predisposes patients to perfusion-demand mismatch. We hypothesized that skeletal muscle and myocardial perfusion, normalized to the degree of anaemia,
Autor:
J. Todd Belcik, William M. Chilian, Jonathan R. Lindner, Azzdine Y. Ammi, Melinda D. Wu, Chae Ryung Chon, Joel Linden, Leanne Harmann, Yue Qi, Joshua J. Field, Aris Xie, Sherry Liang, Mrinal Yadava, Brian P. Davidson
Publikováno v:
Circulation. 135:1240-1252
Background: Augmentation of tissue blood flow by therapeutic ultrasound is thought to rely on convective shear. Microbubble contrast agents that undergo ultrasound-mediated cavitation markedly amplify these effects. We hypothesized that purinergic si
Autor:
Jose A. López, William Packwood, Zaverio M. Ruggeri, Yue Qi, Koya Ozawa, Melinda D. Wu, Aris Xie, Jonathan R. Lindner, Oleg Varlamov
Publikováno v:
Circulation: Cardiovascular Imaging. 11
Background: Complete mechanistic understanding of impaired microvascular reflow after myocardial infarction will likely lead to new therapies for reducing infarct size. Myocardial contrast echocardiography perfusion imaging and molecular imaging were
Autor:
Federico Moccetti, Gabriella Cigarroa, J. Todd Belcik, Azzdine Y. Ammi, Jonathan R. Lindner, Aris Xie, Melinda D. Wu
Publikováno v:
Journal of the American Society of Echocardiography
Background Contrast ultrasound–mediated gene delivery (CUMGD) is a promising approach for enhancing gene therapy that relies on microbubble (MB) cavitation to augment complementary deoxyribonucleic acid (cDNA) transfection. The aims of this study w
Autor:
Brian P. Davidson, Federico Moccetti, P. Barton Duell, Melinda D. Wu, Eran Brown, Sotirios Tsimikas, Sergio Fazio, Jonathan R. Lindner, George D. Giraud, Hagai Tavori, J. Todd Belcik, Tamara Atkinson
Publikováno v:
JACC. Cardiovascular imaging. 12(8 Pt 1)
This study evaluated whether lipoprotein apheresis produces immediate changes in resting perfusion in subjects with severe hypercholesterolemia, and whether there is a difference in the response between peripheral and coronary microcirculations.Lipop