Výsledky vyhledávání - "Melinda C. Myzak"

Olaparib in combination with irinotecan, cisplatin, and mitomycin C in patients with advanced pancreatic cancer

Autor: Burles A. Johnson, Dung T. Le, Elizabeth M. Jaffee, Daniel A. Laheru, Melinda C. Myzak, Michael Goggins, Nilofer S. Azad, Paul E. Oberstein, Ana De Jesus-Acosta, Robert L. Fine, Mark Yarchoan, Lei Zheng, Ross C. Donehower

Publikováno v: Oncotarget

// Mark Yarchoan 1 , Melinda C. Myzak 1 , Burles A. Johnson III 1 , Ana De Jesus-Acosta 1 , Dung T. Le 1 , Elizabeth M. Jaffee 1 , Nilofer S. Azad 1 , Ross C. Donehower 1 , Lei Zheng 1 , Paul E. Oberstein 2 , Robert L. Fine 2 , Daniel A. Laheru 1 and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7fd605f1130396c56caf605ed6a773a
https://pubmed.ncbi.nlm.nih.gov/28454122

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Histone Deacetylases as Targets for Dietary Cancer Preventive Agents: Lessons Learned with Butyrate, Diallyl Disulfide, and Sulforaphane

Autor: Melinda C. Myzak, Roderick H. Dashwood

Publikováno v: Current Drug Targets. 7:443-452

Cancer is a multi-factorial process involving genetic and epigenetic events which result in neoplastic transformation. Reversal of aberrant epigenetic events, including those that modulate the transcriptional activity of genes associated with various

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebaac88b423b74b9cd5a0c0ee248f8dd
https://doi.org/10.2174/138945006776359467

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Dietary agents as histone deacetylase inhibitors

Autor: Melinda C. Myzak, Roderick H. Dashwood, Emily Ho

Publikováno v: Molecular Carcinogenesis. 45:443-446

In cancer cells, an imbalance often exists between histone acetyltransferase (HAT) and histone deacetylase (HDAC) activities, and various drug companies are actively seeking competitive HDAC inhibitors for chemotherapeutic intervention. Cancer cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::511ee015eb7c850da0c8f5deb6082725
https://doi.org/10.1002/mc.20224

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Dietary HDAC inhibitors: time to rethink weak ligands in cancer chemoprevention?

Autor: Melinda C. Myzak, Roderick H. Dashwood, Emily Ho

Publikováno v: Carcinogenesis. 27:344-349

There is growing interest in the various mechanisms that regulate chromatin remodeling, including modulation of histone deacetylase (HDAC) activities. Competitive HDAC inhibitors disrupt the cell cycle and/or induce apoptosis via de-repression of gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f7dc06d3d82ab694e38526cb2f45a9e
https://doi.org/10.1093/carcin/bgi253

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A Novel Mechanism of Chemoprotection by Sulforaphane

Autor: Fung-Lung Chung, Melinda C. Myzak, Roderick H. Dashwood, P. Andrew Karplus

Publikováno v: Cancer Research. 64:5767-5774

Sulforaphane (SFN), a compound found at high levels in broccoli and broccoli sprouts, is a potent inducer of phase 2 detoxification enzymes and inhibits tumorigenesis in animal models. SFN also has a marked effect on cell cycle checkpoint controls an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d0d7dbea4aa1df05c03b85b113016cee
https://doi.org/10.1158/0008-5472.can-04-1326

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Phosphorylation and ubiquitination of oncogenic mutants of β-catenin containing substitutions at Asp32

Autor: Qingjie Li, Melinda C. Myzak, W. Mohaiza Dashwood, Roderick H. Dashwood, Mohamed Al-Fageeh

Publikováno v: Oncogene. 23:4839-4846

Beta-Catenin, a member of the Wnt signaling pathway, is downregulated by glycogen synthase kinase-3beta (GSK-3beta)-dependent phosphorylation of Ser/Thr residues in the N-terminus of the protein, followed by ubiquitination and proteosomal degradation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::779d33b6bead66561663f3059998ad82
https://doi.org/10.1038/sj.onc.1207634

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Myeloperoxidase-dependent caspase-3 activation and apoptosis in HL-60 cells: protection by the antioxidants ascorbate and (dihydro)lipoic acid

Autor: Anitra C. Carr, Melinda C. Myzak

Publikováno v: Redox Report. 7:47-53

The heme enzyme myeloperoxidase (MPO) has recently been implicated in hydrogen peroxide H(2)O(2)-induced apoptosis of HL-60 human leukemia cells. The purpose of this study was to investigate the molecular mechanism(s) of MPO-mediated apoptosis, in pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc0795566109a38ec734bc2aabc4bbb
https://doi.org/10.1179/135100002125000181

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Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects

Autor: Melinda C, Myzak, Philip, Tong, Wan-Mohaiza, Dashwood, Roderick H, Dashwood, Emily, Ho

Publikováno v: Experimental biology and medicine (Maywood, N.J.). 232(2)

Sulforaphane (SFN) is an isothiocyanate found in cruciferous vegetables such as broccoli. This anticarcinogen was first identified as a potent inducer of Phase 2 enzymes, but evidence is mounting that SFN acts through other cancer chemopreventive mec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f88a52f825966ee40a32715e5a5f1d79
https://pubmed.ncbi.nlm.nih.gov/17259330

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Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apcmin mice

Autor: Roderick H. Dashwood, W. Mohaiza Dashwood, Melinda C. Myzak, Gayle A. Orner, Emily Ho

Sulforaphane (SFN) is an isothiocyanate from broccoli that induces phase 2 detoxification enzymes. We recently reported that SFN acts as a histone deacetylase (HDAC) inhibitor in human colon cancer cells in vitro, and the present study sought to exte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caf7225400b49dc59411e10a963ddd4e
https://europepmc.org/articles/PMC2373266/

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