Zobrazeno 1 - 10
of 221
pro vyhledávání: '"Melinda C Aldrich"'
Autor:
Ky'Era V Actkins, Genevieve Jean-Pierre, Melinda C Aldrich, Digna R Velez Edwards, Lea K Davis
Publikováno v:
PLoS Genetics, Vol 19, Iss 5, p e1010764 (2023)
Females with polycystic ovary syndrome (PCOS), the most common endocrine disorder in women, have an increased risk of developing cardiometabolic disorders such as insulin resistance, obesity, and type 2 diabetes (T2D). While only diagnosable in femal
Externí odkaz:
https://doaj.org/article/868b3d05db544dfaba7797f21829c65e
Autor:
Corina Lesseur, Aida Ferreiro-Iglesias, James D McKay, Yohan Bossé, Mattias Johansson, Valerie Gaborieau, Maria Teresa Landi, David C Christiani, Neil C Caporaso, Stig E Bojesen, Christopher I Amos, Sanjay Shete, Geoffrey Liu, Gadi Rennert, Demetrius Albanes, Melinda C Aldrich, Adonina Tardon, Chu Chen, Liloglou Triantafillos, John K Field, Marion Dawn Teare, Lambertus A Kiemeney, Brenda Diergaarde, Robert L Ferris, Shanbeh Zienolddiny, Stephen Lam, Andrew F Olshan, Mark C Weissler, Martin Lacko, Angela Risch, Heike Bickeböller, Andy R Ness, Steve Thomas, Loic Le Marchand, Matthew B Schabath, Victor Wünsch-Filho, Eloiza H Tajara, Angeline S Andrew, Gary M Clifford, Philip Lazarus, Kjell Grankvist, Mikael Johansson, Susanne Arnold, Olle Melander, Hans Brunnström, Stefania Boccia, Gabriella Cadoni, Wim Timens, Ma'en Obeidat, Xiangjun Xiao, Richard S Houlston, Rayjean J Hung, Paul Brennan
Publikováno v:
PLoS Genetics, Vol 17, Iss 3, p e1009254 (2021)
Squamous cell carcinomas (SqCC) of the aerodigestive tract have similar etiological risk factors. Although genetic risk variants for individual cancers have been identified, an agnostic, genome-wide search for shared genetic susceptibility has not be
Externí odkaz:
https://doaj.org/article/1d4a61d6236e418ea99298d8bce6bf87
Autor:
Kathleen Kennedy, Ignacio Jusue-Torres, Ian D. Buller, Emily Rossi, Apurva Mallisetty, Kristen Rodgers, Beverly Lee, Martha Menchaca, Mary Pasquinelli, Ryan H. Nguyen, Frank Weinberg, Israel Rubinstein, James G. Herman, Malcolm Brock, Lawrence Feldman, Melinda C. Aldrich, Alicia Hulbert
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Background Despite recent advances in lung cancer therapeutics and improving overall survival, disparities persist among socially disadvantaged populations. This study aims to determine the effects of neighborhood deprivation indices (NDI) o
Externí odkaz:
https://doaj.org/article/60ad4de4b5b14a6990346e0debb7c4cb
Autor:
Tao Wang, Jee-Young Moon, Yiqun Wu, Christopher I Amos, Rayjean J Hung, Adonina Tardon, Angeline Andrew, Chu Chen, David C Christiani, Demetrios Albanes, Erik H F M van der Heijden, Eric Duell, Gadi Rennert, Gary Goodman, Geoffrey Liu, James D Mckay, Jian-Min Yuan, John K Field, Jonas Manjer, Kjell Grankvist, Lambertus A Kiemeney, Loic Le Marchand, M Dawn Teare, Matthew B Schabath, Mattias Johansson, Melinda C Aldrich, Michael Davies, Mikael Johansson, Ming-Sound Tsao, Neil Caporaso, Philip Lazarus, Stephen Lam, Stig E Bojesen, Susanne Arnold, Xifeng Wu, Xuchen Zong, Yun-Chul Hong, Gloria Y F Ho
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0185660 (2017)
Obesity and cigarette smoking are correlated through complex relationships. Common genetic causes may contribute to these correlations. In this study, we selected 241 loci potentially associated with body mass index (BMI) based on the Genetic Investi
Externí odkaz:
https://doaj.org/article/06527c3a37264b92b9e9945cefdd23db
Autor:
Lindsay N Sausville, Carissa C Jones, Melinda C Aldrich, William J Blot, Ambra Pozzi, Scott M Williams
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180471 (2017)
Globally, lung cancer results in more deaths worldwide than any other cancer, indicating a need for better treatments. Members of the eicosanoid metabolism pathway represent promising therapeutic targets, as several enzymes involved in the generation
Externí odkaz:
https://doaj.org/article/e65e1a27e0bd491abeee6d52aef21177
Autor:
Robert Carreras-Torres, Mattias Johansson, Philip C Haycock, Kaitlin H Wade, Caroline L Relton, Richard M Martin, George Davey Smith, Demetrius Albanes, Melinda C Aldrich, Angeline Andrew, Susanne M Arnold, Heike Bickeböller, Stig E Bojesen, Hans Brunnström, Jonas Manjer, Irene Brüske, Neil E Caporaso, Chu Chen, David C Christiani, W Jay Christian, Jennifer A Doherty, Eric J Duell, John K Field, Michael P A Davies, Michael W Marcus, Gary E Goodman, Kjell Grankvist, Aage Haugen, Yun-Chul Hong, Lambertus A Kiemeney, Erik H F M van der Heijden, Peter Kraft, Mikael B Johansson, Stephen Lam, Maria Teresa Landi, Philip Lazarus, Loïc Le Marchand, Geoffrey Liu, Olle Melander, Sungshim L Park, Gad Rennert, Angela Risch, Eric B Haura, Ghislaine Scelo, David Zaridze, Anush Mukeriya, Milan Savić, Jolanta Lissowska, Beata Swiatkowska, Vladimir Janout, Ivana Holcatova, Dana Mates, Matthew B Schabath, Hongbing Shen, Adonina Tardon, M Dawn Teare, Penella Woll, Ming-Sound Tsao, Xifeng Wu, Jian-Min Yuan, Rayjean J Hung, Christopher I Amos, James McKay, Paul Brennan
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0177875 (2017)
BACKGROUND:Assessing the relationship between lung cancer and metabolic conditions is challenging because of the confounding effect of tobacco. Mendelian randomization (MR), or the use of genetic instrumental variables to assess causality, may help t
Externí odkaz:
https://doaj.org/article/c73ac5a5fb1e4ca89b1b27f8b2510201
Autor:
Ayush Giri, Katherine E Hartmann, Melinda C Aldrich, Renee M Ward, Jennifer M Wu, Amy J Park, Mariaelisa Graff, Lihong Qi, Rami Nassir, Robert B Wallace, Mary J O'Sullivan, Kari E North, Digna R Velez Edwards, Todd L Edwards
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0178839 (2017)
Evidence suggests European American (EA) women have two- to five-fold increased odds of having pelvic organ prolapse (POP) when compared with African American (AA) women. However, the role of genetic ancestry in relation to POP risk is not clear. Her
Externí odkaz:
https://doaj.org/article/74e2cd8a3e2d4bf083cd80acc9b5a488
Autor:
Soheil Baharian, Maxime Barakatt, Christopher R Gignoux, Suyash Shringarpure, Jacob Errington, William J Blot, Carlos D Bustamante, Eimear E Kenny, Scott M Williams, Melinda C Aldrich, Simon Gravel
Publikováno v:
PLoS Genetics, Vol 12, Iss 5, p e1006059 (2016)
We present a comprehensive assessment of genomic diversity in the African-American population by studying three genotyped cohorts comprising 3,726 African-Americans from across the United States that provide a representative description of the popula
Externí odkaz:
https://doaj.org/article/230e1fca123e4f5fb44425aebe0d5c68
Autor:
Nuri Kodaman, Melinda C Aldrich, Rafal Sobota, Folkert W Asselbergs, Kwabena A Poku, Nancy J Brown, Jason H Moore, Scott M Williams
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0162753 (2016)
Populations in sub-Saharan Africa are shifting from rural to increasingly urban. Although the burden of cardiovascular disease is expected to increase with this changing landscape, few large studies have assessed a wide range of risk factors in urban
Externí odkaz:
https://doaj.org/article/30b80de914cf4e9093c9eaf8c0762cf7
Autor:
Jingchun Sun, Min Zhao, Peilin Jia, Lily Wang, Yonghui Wu, Carissa Iverson, Yubo Zhou, Erica Bowton, Dan M Roden, Joshua C Denny, Melinda C Aldrich, Hua Xu, Zhongming Zhao
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 6, p e1004202 (2015)
A drug exerts its effects typically through a signal transduction cascade, which is non-linear and involves intertwined networks of multiple signaling pathways. Construction of such a signaling pathway network (SPNetwork) can enable identification of
Externí odkaz:
https://doaj.org/article/f383be40c6d943a9bedaa0637ff5d4f5