Výsledky vyhledávání - "Melinda, Oros"

Hemoglobin oxidation generates globin-derived peptides in atherosclerotic lesions and intraventricular hemorrhage of the brain, provoking endothelial dysfunction

Autor: Melinda Oros, Csaba Tóth, József Posta, Niké Posta, József Balla, Katalin Éva Sikura, Zoltán Hendrik, Gergő Kalló, Gábor Méhes, György Balla, Éva Csősz, Dávid Pethő, László Potor

Publikováno v: Laboratory Investigation; a Journal of Technical Methods and Pathology

The lysis of red blood cells was shown to occur in human ruptured atherosclerotic lesions and intraventricular hemorrhage (IVH) of the brain. Liberated cell-free hemoglobin was found to undergo oxidation in both pathologies. We hypothesize that hemog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29cd9779da203ba93e70eadd39735851
https://doi.org/10.1038/s41374-020-0403-x

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Potential Role of H-Ferritin in Mitigating Valvular Mineralization

Autor: Maura Poli, Abolfazl Zarjou, Niké Posta, Tamás Szerafin, Lívia Beke, László Potor, József Balla, György Balla, Anupam Agarwal, Melinda Oros, Gábor Méhes, Zoltán Hendrik, Katalin Éva Sikura, Ibolya Fürtös, Paolo Arosio

Objective— Calcific aortic valve disease is a prominent finding in elderly and in patients with chronic kidney disease. We investigated the potential role of iron metabolism in the pathogenesis of calcific aortic valve disease. Approach and Results

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::475ce3d3cf9180eea56ec5351b021d64

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Hydrogen sulfide inhibits calcification of heart valves; implications for calcific aortic valve disease

Autor: Katalin Éva, Sikura, László, Potor, Tamás, Szerafin, Melinda, Oros, Péter, Nagy, Gábor, Méhes, Zoltán, Hendrik, Abolfazl, Zarjou, Anupam, Agarwal, Niké, Posta, Roberta, Torregrossa, Matthew, Whiteman, Ibolya, Fürtös, György, Balla, József, Balla

Publikováno v: British Journal of Pharmacology

Background and Purpose Calcification of heart valves is a frequent pathological finding in chronic kidney disease and in elderly patients. Hydrogen sulfide (H2S) may exert anti‐calcific actions. Here we investigated H2S as an inhibitor of valvular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3c52da91a30c71dfc9bb5051612a1bb3
https://pubmed.ncbi.nlm.nih.gov/31017307

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Hydrogen sulfide inhibits the calcification and osteoblastic differentiation of vascular smooth muscle cells

Autor: József Balla, Erzsébet Zavaczki, Abolfazl Zarjou, György Balla, Anupam Agarwal, Viktória Jeney, Mónika Katkó, Zsuzsa Varga, Melinda Oros

Publikováno v: Kidney International

Osteoblastic differentiation of vascular smooth muscle cells (VSMCs) is involved in the pathogenesis of vascular calcification. Hydrogen sulfide (H(2)S) is a gas endogenously produced by cystathionine γ-lyase in VSMC. Here we determined whether H(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b3768d8b8e2541af72d99408954ab97
https://doi.org/10.1038/ki.2011.212

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STAT6 Transcription Factor Is a Facilitator of the Nuclear Receptor PPARγ-Regulated Gene Expression in Macrophages and Dendritic Cells

Autor: Balint L. Balint, Attila Szanto, John W.R. Schwabe, Yaacov Barak, Zsuzsanna S. Nagy, Attila Pap, Lajos Széles, Balazs Dezso, Endre Barta, Melinda Oros, Laszlo Nagy, Szilárd Póliska, Ronald M. Evans

Publikováno v: Immunity. 33:699-712

SummaryPeroxisome proliferator-activated receptor γ (PPARγ) is a lipid-activated transcription factor regulating lipid metabolism and inflammatory response in macrophages and dendritic cells (DCs). These immune cells exposed to distinct inflammator

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f1591d1355050ee19a532cea1eff242
https://doi.org/10.1016/j.immuni.2010.11.009

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Glutamate receptor metabotropic 7 is cis-regulated in the mouse brain and modulates alcohol drinking

Autor: Mariko Saito, Melinda Oros, Vidudala V. T. S. Prasad, Beatrix M. Gyetvai, Reka Toth, Istvan Szakall, Csaba Vadasz, Krisztina M. Kovacs

Publikováno v: Genomics. 90:690-702

Alcoholism is a heritable disease that afflicts about 8% of the adult population. Its development and symptoms, such as craving, loss of control, physical dependence, and tolerance, have been linked to changes in mesolimbic, mesocortical neurotransmi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b506dfc22116015d9d70d379fbf9e9e5
https://doi.org/10.1016/j.ygeno.2007.08.006

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Mesencephalic dopamine neuron number and tyrosine hydroxylase content: Genetic control and candidate genes

Autor: Beatrix M. Gyetvai, Melinda Oros, Mariko Saito, John F. Smiley, Csaba Vadasz, Krisztina K. Kovacs, Ray Wang, Panaiyur S. Mohan, Reka Toth, Khadija Figarsky

Publikováno v: Neuroscience. 149:561-572

The mesotelencephalic dopamine system shows substantial genetic variation which fundamentally affects normal and pathological behaviors related to motor function, motivation, and learning. Our earlier radioenzyme assay studies demonstrated significan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38e80566667c5e987c31b11b3cf23b7a
https://doi.org/10.1016/j.neuroscience.2007.06.049

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mGluR7 Genetics and Alcohol: Intersection Yields Clues for Addiction

Autor: Beatrix M. Gyetvai, John F. Smiley, Agnes Simonyi, Melinda Oros, Csaba Vadasz, Mariko Saito

Development of addiction to alcohol or other substances can be attributed in part to exposure-dependent modifications at synaptic efficacy leading to an organism which functions at an altered homeostatic setpoint. Genetic factors may also influence s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d7b379a01d91b7dbb5c13f2c7b296d3
https://europepmc.org/articles/PMC4617339/

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