Zobrazeno 1 - 10
of 294
pro vyhledávání: '"Melinda, Gooderham"'
Autor:
Jonathan I. Silverberg, David Rosmarin, Raj Chovatiya, Thomas Bieber, Stephen Schleicher, Lisa Beck, Melinda Gooderham, Sohail Chaudhry, Christie Fanton, Danni Yu, Joshua Levy, Yi Liu, Takahiro Miyazaki, Mary Tagliaferri, Carsten Schmitz, Ajay Nirula, Brian Kotzin, Jonathan Zalevsky
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Regulatory T cell (Treg) impairment is implicated in the pathogenesis of chronic inflammatory diseases, but relatively little is known about the therapeutic potential of Treg restoration. Here we present clinical evidence for the Treg-select
Externí odkaz:
https://doaj.org/article/9bc93354dab940bc992d2c583c1fb98c
Autor:
Andrew F. Alexis, Melinda Gooderham, Shawn G. Kwatra, Ahmad Amin, Susan Taylor, Ramon Espaillat, Trisha Rettig, Tianshuang Wu, Linyu Shi, Mark I. Kaldas, Deanne M. Dilley, Ranjeeta Sinvhal, Chudy Nduaka, Benjamin Lockshin
Publikováno v:
Dermatology and Therapy, Vol 14, Iss 10, Pp 2877-2887 (2024)
Abstract Introduction Historically, patients with skin of color are underdiagnosed with psoriasis and underrepresented in clinical trials. In this study, we assess the efficacy and safety of risankizumab in patients with moderate-to-severe plaque pso
Externí odkaz:
https://doaj.org/article/df8dd512e8ae4dd9b06c7159a85f4dee
Autor:
Mark G. Kirchhof, Vimal H. Prajapati, Melinda Gooderham, Chih-ho Hong, Charles W. Lynde, Catherine Maari, Irina Turchin, Kim A. Papp
Publikováno v:
Dermatology and Therapy, Vol 14, Iss 9, Pp 2653-2668 (2024)
Abstract Oral Janus kinase inhibitors (JAKi), a class of advanced targeted systemic therapy, have demonstrated efficacy and safety in the treatment of moderate-to-severe atopic dermatitis (AD). Like other small molecules, oral JAKi have the potential
Externí odkaz:
https://doaj.org/article/2df4c74225a647e78bc9952cf007f5a2
More Time Spent with Clear Skin and No Itch with Upadacitinib versus Dupilumab for Atopic Dermatitis
Autor:
Andrew Blauvelt, Kilian Eyerich, Alan D. Irvine, Marjolein de Bruin-Weller, Shawn G. Kwatra, Melinda Gooderham, Brian Kim, Brian M. Calimlim, Wan-Ju Lee, Eliza M. Raymundo, Yingyi Liu, Sarah Ofori, Andrew M. Platt, Jonathan I. Silverberg
Publikováno v:
Dermatology and Therapy, Vol 14, Iss 9, Pp 2621-2630 (2024)
Abstract Introduction Atopic dermatitis (AD), with its hallmark symptoms of pruritus and skin lesions, often impairs patients’ quality of life. We assessed time spent with clear/almost clear skin and no/minimal itch during upadacitinib treatment ve
Externí odkaz:
https://doaj.org/article/f20cd55b09a34e87a0a91cfbd7f735cf
Autor:
Jonathan I. Silverberg, MD, PhD, MPH, Angel Cronin, MS, Eric A. Jones, PhD, MPH, Swapna S. Dave, MPH, MBBS, Robert R. McLean, DSc, MPH, Jeffrey Greenberg, MD, MPH, Bruce Strober, MD, PhD, Thomas Bieber, MD, PhD, MDRA, Melinda Gooderham, MSc, MD, Amy S. Paller, MD, Eric L. Simpson, MD
Publikováno v:
JAAD International, Vol 15, Iss , Pp 127-130 (2024)
Externí odkaz:
https://doaj.org/article/4aa74d6d47df4db780c150abfeeb072f
Autor:
Eric L. Simpson, Marjolein de Bruin-Weller, H. Chih-ho Hong, Delphine Staumont-Sallé, Andrew Blauvelt, Kilian Eyerich, Melinda Gooderham, Mona Shahriari, Lotus Mallbris, Amber Reck Atwater, Maria Jose Rueda, Yuxin Ding, Zhuqing Liu, Helena Agell, Jonathan I. Silverberg
Publikováno v:
Dermatology and Therapy, Vol 14, Iss 5, Pp 1145-1160 (2024)
Abstract Introduction Atopic dermatitis (AD) affects multiple areas of the body, some of which may be more refractory to treatment. We evaluated improvements in the Eczema Area and Severity Index (EASI) by body region and clinical signs for each body
Externí odkaz:
https://doaj.org/article/837994b491e148fd89376ffe68c7f997
Autor:
Alexander Egeberg, Jason E. Hawkes, Najwa Somani, Russel Burge, Kyoungah See, Gaia Gallo, Missy McKean-Matthews, Melinda Gooderham, George Han, April Armstrong
Publikováno v:
Dermatology and Therapy, Vol 14, Iss 4, Pp 1007-1018 (2024)
Abstract Introduction Ixekizumab, a high-affinity monoclonal antibody that selectively targets interleukin-17A, is approved for the treatment of moderate-to-severe plaque psoriasis. Since scalp psoriasis can be burdensome and challenging to treat wit
Externí odkaz:
https://doaj.org/article/2172459873774bdcb1e836294768df9a
Autor:
Neil J. Korman, Richard B. Warren, Jerry Bagel, April W. Armstrong, Melinda Gooderham, Bruce Strober, Diamant Thaçi, Akimichi Morita, Shinichi Imafuku, Peter Foley, Howard Sofen, Min Zheng, Lauren Hippeli, Renata M. Kisa, Subhashis Banerjee, Andrew Blauvelt
Publikováno v:
Journal of Dermatological Treatment, Vol 35, Iss 1 (2024)
Aim: In the global phase 3 POETYK PSO-1 and PSO-2 trials, significantly greater proportions of deucravacitinib-treated patients met the coprimary endpoints (PASI 75, sPGA 0/1) at Week 16 versus placebo or apremilast-treated patients. This analysis ev
Externí odkaz:
https://doaj.org/article/565ff6e9db3f40f3996833c3bba76026
Autor:
Richie Jeremian, PhD, Alexandra Malinowski, PhD, Edward S. Oh, PhD, Melinda Gooderham, MD, MSc, FRCPC, Cathryn Sibbald, MD, MSc, FRCPC, Jensen Yeung, MD, FRCPC, Yuka Asai, MD, FRCPC, Vincent Piguet, MD, PhD, FRCP, Carolyn S. Jack, MDCM, PhD, FRCPC
Publikováno v:
Journal of Allergy and Clinical Immunology: Global, Vol 3, Iss 3, Pp 100275- (2024)
Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease resulting from the complex interplay of genetic and environmental factors, meriting exploration using temporally dynamic biomarkers. DNA methylation–based algorithms have bee
Externí odkaz:
https://doaj.org/article/2853b5def97442e0bafcd8310d7bf75d
Autor:
Melinda Gooderham, Ronald Vender, Jeffrey Crowley, H. Chih-Ho Hong, Meghan Feely, Alyssa Garrelts, Kyoungah See, Bruce Konicek, Lawrence Green
Publikováno v:
Dermatology and Therapy, Vol 14, Iss 2, Pp 441-451 (2024)
Abstract Introduction When assessing the effect of a therapy for psoriasis (PsO), it is important to consider speed of response and cumulative response. However, responses among biologics may differ by body regions. This post hoc analysis compares sp
Externí odkaz:
https://doaj.org/article/f00c3bb6c4ff40e9a728bb090f968f07