Zobrazeno 1 - 10
of 135
pro vyhledávání: '"Melina Claussnitzer"'
Autor:
Melina Claussnitzer, Victoria N. Parikh, Alex H. Wagner, Jeremy A. Arbesfeld, Carol J. Bult, Helen V. Firth, Lara A. Muffley, Alex N. Nguyen Ba, Kevin Riehle, Frederick P. Roth, Daniel Tabet, Benedetta Bolognesi, Andrew M. Glazer, Alan F. Rubin
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-8 (2024)
Abstract Multiplexed assays of variant effect (MAVEs) have emerged as a powerful approach for interrogating thousands of genetic variants in a single experiment. The flexibility and widespread adoption of these techniques across diverse disciplines h
Externí odkaz:
https://doaj.org/article/ee5b2abbc9bf4533aed98196fa9861b1
Autor:
Tanja Krauss, Simone Heisz, Julius Honecker, Olga Prokopchuk, Marc Martignoni, Klaus‐Peter Janssen, Melina Claussnitzer, Hans Hauner, Claudine Seeliger
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 3, Pp 1381-1394 (2023)
Abstract Background Cancer cachexia (CCx) is a complex and multi‐organ wasting syndrome characterized by substantial weight loss and poor prognosis. An improved understanding of the mechanisms involved in the onset and progression of cancer cachexi
Externí odkaz:
https://doaj.org/article/fa2b9d86fd734cea8f952ca7d9b532be
Autor:
Saaket Agrawal, Marcus D. R. Klarqvist, Nathaniel Diamant, Takara L. Stanley, Patrick T. Ellinor, Nehal N. Mehta, Anthony Philippakis, Kenney Ng, Melina Claussnitzer, Steven K. Grinspoon, Puneet Batra, Amit V. Khera
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Different location of adipose tissue may have different consequences to cardiometabolic risk. Here the authors report that deep learning enabled accurate prediction of specific adipose tissue volumes, and that after adjustment for BMI, visceral adipo
Externí odkaz:
https://doaj.org/article/d7844d42ac8a4868b82bf39c7f4b10d7
Autor:
Saaket Agrawal, Minxian Wang, Marcus D. R. Klarqvist, Kirk Smith, Joseph Shin, Hesam Dashti, Nathaniel Diamant, Seung Hoan Choi, Sean J. Jurgens, Patrick T. Ellinor, Anthony Philippakis, Melina Claussnitzer, Kenney Ng, Miriam S. Udler, Puneet Batra, Amit V. Khera
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The inherited basis of body fat distribution is not fully understood. Here, the authors use genetic data and MRI-derived measures of local adiposity to highlight fat depot-specific genetic architecture with implications for cardiometabolic health.
Externí odkaz:
https://doaj.org/article/708f44bb6b094581a53300838b54ced3
Autor:
Claudine Seeliger, Tanja Krauss, Julius Honecker, Laura Aline Mengel, Lise Buekens, Alberto Mesas-Fernández, Thomas Skurk, Melina Claussnitzer, Hans Hauner
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Activation of brown adipose tissue may increase energy expenditure by non-shivering thermogenesis. Cold exposure is one of the options to activate brown adipocytes. To link changes in energy metabolism with microRNA expression (miRNAs), we a
Externí odkaz:
https://doaj.org/article/87ffb9bbbc104b9f8773e49bb162ae52
Autor:
Mi Huang, Daniel Coral, Hamidreza Ardalani, Peter Spegel, Alham Saadat, Melina Claussnitzer, Hindrik Mulder, Paul W Franks, Sebastian Kalamajski
Publikováno v:
eLife, Vol 12 (2023)
Genetic variation at the MTIF3 (Mitochondrial Translational Initiation Factor 3) locus has been robustly associated with obesity in humans, but the functional basis behind this association is not known. Here, we applied luciferase reporter assay to m
Externí odkaz:
https://doaj.org/article/ec3b46da82fb44d690ce61ef78e46cc2
Autor:
Julius Honecker, Stefan Ruschke, Claudine Seeliger, Samantha Laber, Sophie Strobel, Priska Pröll, Christoffer Nellaker, Cecilia M. Lindgren, Ulrich Kulozik, Josef Ecker, Dimitrios C. Karampinos, Melina Claussnitzer, Hans Hauner
Publikováno v:
EBioMedicine, Vol 79, Iss , Pp 104020- (2022)
Summary: Background: The adipocyte-hypertrophy associated remodeling of fat cell function is considered causal for the development of metabolic disorders. A better understanding of transcriptome and fatty acid (FA) related alterations with adipocyte
Externí odkaz:
https://doaj.org/article/8ca88a6bac474c2aaf4c512d3c688d69
Autor:
Laura Aline Mengel, Bahareh Nemati Moud, Hatti Seidl, Alberto Mesas-Fernández, Claudine Seeliger, Beate Brandl, Thomas Skurk, Christina Holzapfel, Melina Claussnitzer, Hans Hauner
Publikováno v:
Obesity Facts (2022)
Introduction. Brown adipose tissue (BAT) serves to produce heat by non-shivering thermogenesis. Activation of BAT increases energy expenditure and is seen as a putative strategy to treat obesity. There is conflicting data on the capacity for cold ind
Externí odkaz:
https://doaj.org/article/dc2daa11fce04ab7bfc8ee616d623030
Autor:
Xinchen Wang, Liang He, Sarah M. Goggin, Alham Saadat, Li Wang, Nasa Sinnott-Armstrong, Melina Claussnitzer, Manolis Kellis
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Millions of enhancers are predicted, but their validation remains challenging. Here, the authors report genome-wide enhancer function quantification and high-resolution dissection for millions of accessible DNA fragments, revealing driver nucleotides
Externí odkaz:
https://doaj.org/article/b840b6fe3d734ff1922a52f00577dac1
Autor:
Grace T. Hansen, Débora R. Sobreira, Zachary T. Weber, Alexis G. Thornburg, Ivy Aneas, Li Zhang, Noboru J. Sakabe, Amelia C. Joslin, Gabriela A. Haddad, Sophie M. Strobel, Samantha Laber, Farhath Sultana, Faezeh Sahebdel, Kohinoor Khan, Yang I. Li, Melina Claussnitzer, Liang Ye, Ricardo A. Battaglino, Marcelo A. Nóbrega
Publikováno v:
Nature Genetics. 55:461-470
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ed2a5480ebc07311ae545c7d9979da4
https://doi.org/10.1038/s41588-023-01306-0
https://doi.org/10.1038/s41588-023-01306-0