Crosstalk between the serine/threonine kinase StkP and the response regulator ComE controls the stress response and intracellular survival of Streptococcus pneumoniae.

Autor: Germán E Piñas, Nicolás M Reinoso-Vizcaino, Nubia Y Yandar Barahona, Paulo R Cortes, Rosario Duran, Chandan Badapanda, Ankita Rathore, Dario R Bichara, Melina B Cian, Nadia B Olivero, Daniel R Perez, José Echenique

Publikováno v: PLoS Pathogens, Vol 14, Iss 6, p e1007118 (2018)

Streptococcus pneumoniae is an opportunistic human bacterial pathogen that usually colonizes the upper respiratory tract, but the invasion and survival mechanism in respiratory epithelial cells remains elusive. Previously, we described that acidic st

Externí odkaz: https://doaj.org/article/949c61ea3c7b4caeb4ea38e5755084b0

The oxidative stress response of Streptococcus pneumoniae: its contribution to both extracellular and intracellular survival

Autor: Mirelys Hernandez-Morfa, Nadia B. Olivero, Victoria E. Zappia, German E. Piñas, Nicolas M. Reinoso-Vizcaino, Melina B. Cian, Mariana Nuñez-Fernandez, Paulo R. Cortes, Jose Echenique

Publikováno v: Frontiers in Microbiology, Vol 14 (2023)

Streptococcus pneumoniae is a gram-positive, aerotolerant bacterium that naturally colonizes the human nasopharynx, but also causes invasive infections and is a major cause of morbidity and mortality worldwide. This pathogen produces high levels of H

Externí odkaz: https://doaj.org/article/577cbd1485234d57a32a8e3068e3b284

Outer Membrane Lipid Secretion and the Innate Immune Response to Gram-Negative Bacteria

Autor: Melina B. Cian, Nicole P. Giordano, Zachary D. Dalebroux

Publikováno v: Infect Immun

The outer membrane (OM) of Gram-negative bacteria is an asymmetric lipid bilayer that consists of inner leaflet phospholipids and outer leaflet lipopolysaccharides (LPS). The asymmetric character and unique biochemistry of LPS molecules contribute to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6be386fceb85f04e22bb5ba5ffda3564
https://europepmc.org/articles/PMC7309610/

Separation of the Cell Envelope for Gram-negative Bacteria into Inner and Outer Membrane Fractions with Technical Adjustments for Acinetobacter baumannii

Autor: Keaton E. Minor, Nicole P. Giordano, Melina B. Cian, Zachary D. Dalebroux, Joshua A. Mettlach

Publikováno v: Journal of Visualized Experiments.

This method works by partitioning the envelope of Gram-negative bacteria into total, inner, and outer membrane (OM) fractions and concludes with assays to assess the purity of the bilayers. The OM has an increased overall density compared to the inne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d16fd899573821a0b5a00023848f12ff
https://doi.org/10.3791/60517-v

The pneumococcal two-component system SirRH is linked to enhanced intracellular survival of Streptococcus pneumoniae in influenza-infected pulmonary cells

Autor: Germán E. Piñas, Ankita Rathore, Daniel R. Perez, Paulo R. Cortes, Nicolás M. Reinoso-Vizcaíno, Melina B. Cian, Chandan Badapanda, Mirelys Hernandez-Morfa, Nadia B. Olivero, José Echenique

Publikováno v: PLoS Pathogens
Repositorio Digital Universitario (UNC)
Universidad Nacional de Córdoba
instacron:UNC
PLoS Pathogens, Vol 16, Iss 8, p e1008761 (2020)

The virus-bacterial synergism implicated in secondary bacterial infections caused by Streptococcus pneumoniae following infection with epidemic or pandemic influenza A virus (IAV) is well documented. However, the molecular mechanisms behind such syne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd3ef8e7723888417ca3cf7f2ac2c3b5
https://pubmed.ncbi.nlm.nih.gov/32790758