Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Melika Bonakdar"'
Autor:
Rebecca J. Deyell, Yaoqing Shen, Emma Titmuss, Katherine Dixon, Laura M. Williamson, Erin Pleasance, Jessica M. T. Nelson, Sanna Abbasi, Martin Krzywinski, Linlea Armstrong, Melika Bonakdar, Carolyn Ch’ng, Eric Chuah, Chris Dunham, Alexandra Fok, Martin Jones, Anna F. Lee, Yussanne Ma, Richard A. Moore, Andrew J. Mungall, Karen L. Mungall, Paul C. Rogers, Kasmintan A. Schrader, Alice Virani, Kathleen Wee, Sean S. Young, Yongjun Zhao, Steven J. M. Jones, Janessa Laskin, Marco A. Marra, Shahrad R. Rassekh
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The role for routine whole genome and transcriptome analysis (WGTA) for poor prognosis pediatric cancers remains undetermined. Here, we characterize somatic mutations, structural rearrangements, copy number variants, gene expression, immuno-
Externí odkaz:
https://doaj.org/article/7e4974acf7f14999a67996f77a1aac77
Autor:
Caralyn Reisle, Laura M. Williamson, Erin Pleasance, Anna Davies, Brayden Pellegrini, Dustin W. Bleile, Karen L. Mungall, Eric Chuah, Martin R. Jones, Yussanne Ma, Eleanor Lewis, Isaac Beckie, David Pham, Raphael Matiello Pletz, Amir Muhammadzadeh, Brandon M. Pierce, Jacky Li, Ross Stevenson, Hansen Wong, Lance Bailey, Abbey Reisle, Matthew Douglas, Melika Bonakdar, Jessica M. T. Nelson, Cameron J. Grisdale, Martin Krzywinski, Ana Fisic, Teresa Mitchell, Daniel J. Renouf, Stephen Yip, Janessa Laskin, Marco A. Marra, Steven J. M. Jones
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
The interpretation of somatic variants in cancer is challenging due to the scale and complexity of sequencing data. Here, the authors present PORI, an open-source framework for interpreting somatic variants in cancer using graph knowledge base tools,
Externí odkaz:
https://doaj.org/article/5c7ff25c4b804a56a09afa4f5a34016d
Autor:
Jake Lever, Martin R. Jones, Arpad M. Danos, Kilannin Krysiak, Melika Bonakdar, Jasleen K. Grewal, Luka Culibrk, Obi L. Griffith, Malachi Griffith, Steven J. M. Jones
Publikováno v:
Genome Medicine, Vol 11, Iss 1, Pp 1-16 (2019)
Abstract Background Precision oncology involves analysis of individual cancer samples to understand the genes and pathways involved in the development and progression of a cancer. To improve patient care, knowledge of diagnostic, prognostic, predispo
Externí odkaz:
https://doaj.org/article/6895b455f4b64a50aa070e6e9642ac60
Autor:
Cameron J. Grisdale, Scott D. Brown, Kevin Y. Fan, Wei Zhang, Caralyn Reisle, Zoltan Bozoky, Robert A. Holt, Tariq Vira, Richard Corbett, Melika Bonakdar, My Linh Thibodeau, Kathleen Wee, Dean Cheng, Luka Culibrk, Marcus Carreira, David F. Schaeffer, Deirdre Weymann, Anna V. Tinker, Eric Y. Zhao, Michael K.C. Lee, Karen A. Gelmon, Karen Mungall, Richard A. Moore, Dean A. Regier, Daniel J. Renouf, Zusheng Zong, Reva Shenwai, Stephen Chia, Jahanshah Ashkani, Ana Fisic, Stephen Yip, Darryl D’Souza, Yussanne Ma, Daniel MacMillan, Erin Pleasance, Steve Bilobram, Alexandra Fok, Amir Muhammadzadeh, Jean-Michel Lavoie, Martin R. Jones, Hillary Pearson, Simon K. Chan, Balvir Deol, Steven J.M. Jones, Andrew J. Mungall, Mya Warren, Gregory A. Taylor, Elisa Majounie, Harwood H. Kwan, Eric Chuah, Howard John Lim, Sara Sadeghi, Dustin Bleile, Emma Titmuss, Reanne Bowlby, Anna Davies, Laura Williamson, Jessica Nelson, Caleb Choo, Jasleen K. Grewal, Katherine Dixon, Yongjun Zhao, Shehara Mendis, Yaoqing Shen, Janessa Laskin, Joanna M. Karasinska, Veronika Csizmok, Tina Wong, Sophie Sun, Kasmintan A. Schrader, Marco A. Marra
Publikováno v:
Nature Cancer. 1:452-468
Advanced and metastatic tumors with complex treatment histories drive cancer mortality. Here we describe the POG570 cohort, a comprehensive whole-genome, transcriptome and clinical dataset, amenable for exploration of the impacts of therapies on geno
Autor:
Janessa Laskin, Emma Titmuss, Krista Noonan, Melika Bonakdar, Christine Simmons, Howard John Lim, Eric Y. Zhao, Karen A. Gelmon, Kong Khoo, Martin L. Jones, M. Knowling, Tony Ng, Yaoqing Shen, Greg Taylor, Jennifer Rauw, Eric Chuah, Jasleen K. Grewal, Jason Hart, R. Petter Tonseth, Stephen Yip, Amirrtha Srikanthan, Simon K. Chan, Karen Mungall, S. Rod Rassekh, Sara Kristina Taylor, Yongjun Zhao, Nissreen Mohammad, Xiaolan Feng, Rebecca J. Deyell, Daniel J. Renouf, Andrew J. Mungall, Ursula Lee, Marco A. Marra, Richard D. Moore, Caralyn Reisle, Erin Pleasance, Steven J.M. Jones
Publikováno v:
JCO Precision Oncology. :1-25
PURPOSE This study investigated therapeutic potential of integrated genome and transcriptome profiling of metastatic sarcoma, a rare but extremely heterogeneous group of aggressive mesenchymal malignancies with few systemic therapeutic options. METHO
Autor:
Arpad Danos, Obi L. Griffith, Jake Lever, Jasleen K. Grewal, Martin R. Jones, Luka Culibrk, Steven J.M. Jones, Melika Bonakdar, Malachi Griffith, Kilannin Krysiak
Publikováno v:
Genome Medicine, Vol 11, Iss 1, Pp 1-16 (2019)
Genome Medicine
Genome Medicine
Background Precision oncology involves analysis of individual cancer samples to understand the genes and pathways involved in the development and progression of a cancer. To improve patient care, knowledge of diagnostic, prognostic, predisposing, and
Autor:
B. M. Pierce, I. Beckie, R. Stevenson, B. Pellegrini, Melika Bonakdar, L. Bailey, Laura Williamson, A. Muhammadzadeh, E. Chuah, M. Douglas, Stephen Yip, Martin Jones, Martin Krzywinski, D. W. Bleile, A. Fisic, Yussanne Ma, R. Matiello Pletz, T. Mitchell, Erin Pleasance, Janessa Laskin, Cameron J. Grisdale, D. Pham, Jessica Nelson, A. Davies, H. Wong, Karen Mungall, Marco A. Marra, C. Reisle, Daniel J. Renouf, A. Reisle, Sjm Jones, Jun Li
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Manual interpretation of variants remains rate limiting in precision oncology. The increasing scale and complexity of molecular data generated from comprehensive sequencing of cancer samples requires advanced interpretative platforms as precision onc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f16aeb295c6d7158c4be90e8831f3d18
https://doi.org/10.1101/2021.04.13.439667
https://doi.org/10.1101/2021.04.13.439667
Autor:
Daniel J. Renouf, Richard A. Moore, Eric Chuah, Emma Titmuss, Janessa Laskin, Cameron J. Grisdale, Howard John Lim, Jean-Michel Lavoie, Alexandra Pender, Andrew J. Mungall, Sophie Sun, Steven J.M. Jones, Erin Pleasance, Stephen Yip, Melika Bonakdar, Laura Williamson, Karen Mungall, James T. Topham, Robert A. Holt, Hillary Pearson, Gregory A. Taylor, Kevin Y. Fan, Marco A. Marra, Scott D. Brown, Yaoqing Shen
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 27(1)
Purpose: Immune checkpoint inhibitors (ICI) have revolutionized the treatment of solid tumors with dramatic and durable responses seen across multiple tumor types. However, identifying patients who will respond to these drugs remains challenging, par
Autor:
Richard A. Moore, Melika Bonakdar, Stephen Yip, Karen Mungall, Erin Pleasance, Alexandra Pender, Emma Titmuss, Sophie Sun, Steven J.M. Jones, Jean-Michel Lavoie, James T. Topham, Daniel J. Renouf, Janessa Laskin, Laura Williamson, Andrew J. Mungall, Cameron J. Grisdale, Gregory A. Taylor, Eric Chuah, Robert A. Holt, Yaoqing Shen, Marco A. Marra, Howard John Lim, Scott D. Brown
Publikováno v:
Cancer Research. 81:1647-1647
Dramatic and durable responses to immune checkpoint inhibitors (ICIs) have been observed across multiple tumor types, but identifying the patients most likely to respond to these drugs remains challenging, particularly in the context of metastatic an
Autor:
Gregory A. Taylor, Emma Tittmus, D.J. Renouf, Kathleen Wee, Karen Mungall, Richard A. Moore, Yaoqing Shen, Lim Howard John, Veronika Csizmok, Alexandra Bohm, Caralyn Reisle, Steven J. M. Jones, Erin Pleasance, Janessa Laskin, Melika Bonakdar, Jessica Nelson, Marco Marra, Sophie Sun, Andrew J. Mungall, Eric Chuah, Balvir Deol, Laura Williamson, Martin Jones
Publikováno v:
Cancer Research. 81:98-98
Sequencing technology is increasingly essential in clinical cancer management. The majority of clinical cancer sequencing has focused on panel approaches, but recent trials have begun to report the use of transcriptome expression profiling to match p