Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348).

Autor: Fensome A; Chemical and Screening Sciences, Biotransformation Division, Drug Safety and Metabolism, Women's Health and Musculoskeletal Biology, and BioResources, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA. fensoma@wyeth.com, Adams WR, Adams AL, Berrodin TJ, Cohen J, Huselton C, Illenberger A, Kern JC, Hudak VA, Marella MA, Melenski EG, McComas CC, Mugford CA, Slayden OD, Yudt M, Zhang Z, Zhang P, Zhu Y, Winneker RC, Wrobel JE

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2008 Mar 27; Vol. 51 (6), pp. 1861-73. Date of Electronic Publication: 2008 Mar 05.

Non-Metal Catalyzed Synthesis : Bioactive Heterocycles

Autor: Yunfei Du, Bubun Banerjee

Non-metal catalysis may provide new and green methods for obtaining bioactive heterocycles. Many catalysts contain metals, which can be toxic, energy intensive to remove, and require mining of the source materials. By utilizing metal-free catalysts w