DNA damage-induced phosphorylation of a replicative DNA helicase results in inhibition of DNA replication through attenuation of helicase function.

Autor: Homiski C; Departments of Microbiology & Immunology and Biochemistry, and the Witebsky Center for Microbial Pathogenesis & Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York at Buffalo, Buffalo, NY 14203, USA., Dey-Rao R; Departments of Microbiology & Immunology and Biochemistry, and the Witebsky Center for Microbial Pathogenesis & Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York at Buffalo, Buffalo, NY 14203, USA., Shen S; Department of Pharmaceutical Sciences, University at Buffalo, State University of New York at Buffalo, Buffalo, NY 14203, USA; NYS Center of Excellence in Bioinformatics and Life Sciences, University at Buffalo, Buffalo, NY 14203, USA., Qu J; Department of Pharmaceutical Sciences, University at Buffalo, State University of New York at Buffalo, Buffalo, NY 14203, USA; NYS Center of Excellence in Bioinformatics and Life Sciences, University at Buffalo, Buffalo, NY 14203, USA., Melendy T; Departments of Microbiology & Immunology and Biochemistry, and the Witebsky Center for Microbial Pathogenesis & Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York at Buffalo, Buffalo, NY 14203, USA.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2024 Sep 23; Vol. 52 (17), pp. 10311-10328.

A synergistic two-drug therapy specifically targets a DNA repair dysregulation that occurs in p53-deficient colorectal and pancreatic cancers.

Autor: Alruwaili MM; Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA; Department of Medical Laboratory Technology, College of Applied Medical Science, Northern Border University, Arar City, Saudi Arabia., Zonneville J; Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA., Naranjo MN; Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA., Serio H; Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA., Melendy T; Department of Microbiology and Immunology, University at Buffalo, Buffalo, NY 14214, USA., Straubinger RM; Department of Pharmaceutical Sciences, University at Buffalo, Buffalo, NY 14214, USA; Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA., Gillard B; Department of Pharmaceutical Sciences, University at Buffalo, Buffalo, NY 14214, USA., Foster BA; Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA., Rajan P; Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA., Attwood K; Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA., Chatley S; Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA., Iyer R; Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA., Fountzilas C; Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA. Electronic address: christos.fountzilas@roswellpark.org., Bakin AV; Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA. Electronic address: andrei.bakin@roswellpark.org.

Publikováno v: Cell reports. Medicine [Cell Rep Med] 2024 Mar 19; Vol. 5 (3), pp. 101434. Date of Electronic Publication: 2024 Feb 21.

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Unorthodox PCNA Binding by Chromatin Assembly Factor 1.

Autor: Gopinathan Nair A; Institute for Research in Immunology and Cancer, University of Montreal, Montreal, QC H3T 1J4, Canada.; Molecular Biology Program, University of Montreal, Montreal, QC H3T 1J4, Canada., Rabas N; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK., Lejon S; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK., Homiski C; Departments of Biochemistry and Microbiology & Immunology, University at Buffalo Jacobs School of Medicine & Biomedical Sciences, 955 Main Street, Buffalo, NY 14210, USA., Osborne MJ; Institute for Research in Immunology and Cancer, University of Montreal, Montreal, QC H3T 1J4, Canada., Cyr N; Department of Biochemistry and Molecular Medicine, University of Montreal, Montreal, QC H3C 3J7, Canada., Sverzhinsky A; Department of Biochemistry and Molecular Medicine, University of Montreal, Montreal, QC H3C 3J7, Canada., Melendy T; Departments of Biochemistry and Microbiology & Immunology, University at Buffalo Jacobs School of Medicine & Biomedical Sciences, 955 Main Street, Buffalo, NY 14210, USA., Pascal JM; Department of Biochemistry and Molecular Medicine, University of Montreal, Montreal, QC H3C 3J7, Canada., Laue ED; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK., Borden KLB; Institute for Research in Immunology and Cancer, University of Montreal, Montreal, QC H3T 1J4, Canada.; Department of Pathology and Cell Biology, University of Montreal, Montreal, QC H3T 1J4, Canada., Omichinski JG; Department of Biochemistry and Molecular Medicine, University of Montreal, Montreal, QC H3C 3J7, Canada., Verreault A; Institute for Research in Immunology and Cancer, University of Montreal, Montreal, QC H3T 1J4, Canada.; Department of Pathology and Cell Biology, University of Montreal, Montreal, QC H3T 1J4, Canada.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2022 Sep 21; Vol. 23 (19). Date of Electronic Publication: 2022 Sep 21.

A fluorescence-based, gain-of-signal, live cell system to evaluate SARS-CoV-2 main protease inhibition.

Autor: Dey-Rao R; Department of Microbiology & Immunology, Jacobs School of Medicine & Biomedical Sciences, University at Buffalo, 955 Main St., Buffalo, NY, 14203, USA., Smith GR; Department of Microbiology & Immunology, Jacobs School of Medicine & Biomedical Sciences, University at Buffalo, 955 Main St., Buffalo, NY, 14203, USA., Timilsina U; Department of Microbiology & Immunology, Jacobs School of Medicine & Biomedical Sciences, University at Buffalo, 955 Main St., Buffalo, NY, 14203, USA., Falls Z; Department of Biomedical Informatics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, 14203, USA., Samudrala R; Department of Biomedical Informatics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, 14203, USA., Stavrou S; Department of Microbiology & Immunology, Jacobs School of Medicine & Biomedical Sciences, University at Buffalo, 955 Main St., Buffalo, NY, 14203, USA., Melendy T; Department of Microbiology & Immunology, Jacobs School of Medicine & Biomedical Sciences, University at Buffalo, 955 Main St., Buffalo, NY, 14203, USA. Electronic address: TMelendy@buffalo.edu.

Publikováno v: Antiviral research [Antiviral Res] 2021 Nov; Vol. 195, pp. 105183. Date of Electronic Publication: 2021 Oct 07.