Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Melendhran, Pillay"'
Autor:
Lilishia Gounder, Aabida Khan, Justen Manasa, Richard Lessells, Andrew Tomita, Melendhran Pillay, Sontaga C. Manyana, Subitha Govender, Kerri-Lee Francois, Pravi Moodley, Nokukhanya Msomi, Kerusha Govender, Raveen Parboosing, Sikhulile Moyo, Kogieleum Naidoo, Benjamin Chimukangara
Publikováno v:
Viruses, Vol 16, Iss 10, p 1634 (2024)
HIV-1 drug resistance (HIVDR) impedes treatment and control of HIV-1, especially in high-prevalence settings such as KwaZulu-Natal (KZN) province, South Africa. This study merged routine HIV-1 genotypic resistance test (GRT) data with Geographic Info
Externí odkaz:
https://doaj.org/article/9b3d7477fcde4994875db26cd6c2d8f2
Autor:
Tamlyn A. Rautenberg, Shu Kay Ng, Gavin George, Mahomed-Yunus S. Moosa, Suzanne M. McCluskey, Rebecca F. Gilbert, Selvan Pillay, Isaac Aturinda, Kevin L. Ard, Winnie R. Muyindike, Nicholas Musinguzi, Godfrey Masette, Melendhran Pillay, Pravi Moodley, Jaysingh Brijkumar, Rajesh T. Gandhi, Brent Johnson, Henry Sunpath, Mwebesa B. Bwana, Vincent C. Marconi, Mark J. Siedner
Publikováno v:
Health and Quality of Life Outcomes, Vol 21, Iss 1, Pp 1-8 (2023)
Abstract Background Antiretroviral treatment improves health related quality of life (HRQoL) of people with human immunodeficiency virus (PWH). However, one third initiating first-line treatment experience virological failure and the determinants of
Externí odkaz:
https://doaj.org/article/d2b188a0d0b546e59e050e2059d1f1ea
Autor:
Lilishia Gounder, Andrew Tomita, Richard Lessells, Sandrini Moodley, Kerri-Lee Francois, Aabida Khan, Melendhran Pillay, Sontaga C Manyana, Subitha Govender, Kerusha Govender, Pravi Moodley, Raveen Parboosing, Nokukhanya Msomi, Frank Tanser, Kogieleum Naidoo, Benjamin Chimukangara
Publikováno v:
PLOS Global Public Health, Vol 4, Iss 5, p e0003224 (2024)
South Africa rolled out dolutegravir (DTG) as first-line antiretroviral therapy (ART) in December 2019 to overcome high rates of pretreatment non-nucleoside reverse transcriptase inhibitor drug resistance. In the context of transition to DTG-based AR
Externí odkaz:
https://doaj.org/article/d67f1eec97dc4715a89305e9d69f3aa4
Autor:
Sontaga Manyana, Melendhran Pillay, Lilishia Gounder, Aabida Khan, Pravi Moodley, Kogieleum Naidoo, Benjamin Chimukangara
Publikováno v:
AIDS Research and Therapy, Vol 20, Iss 1, Pp 1-12 (2023)
Abstract Background As use of dolutegravir (DTG) becomes more common in resource limited settings (RLS), the demand for integrase resistance testing is increasing. Affordable methods for genotyping all relevant HIV-1 pol genes (i.e., protease (PR), r
Externí odkaz:
https://doaj.org/article/c4e8e08238a9408b8eb06dda5410cd9f
Autor:
Aabida Khan, Melendhran Pillay, Benjamin Chimukangara, Lilishia Gounder, Sontaga Manyana, Kerri-Lee Francois, Knowledge Chipango
Publikováno v:
Journal of Clinical Virology Plus, Vol 3, Iss 2, Pp 100143- (2023)
The most common HIV-1 subtype in South Africa is subtype C, and detection of other subtypes is rare. We report the first known case of HIV-1 subtype CRF18_cpx identified in KwaZulu-Natal, South Africa, the epicenter of the HIV epidemic, through HIV d
Externí odkaz:
https://doaj.org/article/5ccee41eb8644618bd2c0ed62edc0836
Autor:
Benjamin Chimukangara, Richard J. Lessells, Benn Sartorius, Lilishia Gounder, Sontaga Manyana, Melendhran Pillay, Lavanya Singh, Jennifer Giandhari, Kerusha Govender, Reshmi Samuel, Nokukhanya Msomi, Kogieleum Naidoo, Tulio de Oliveira, Pravi Moodley, Raveen Parboosing
Publikováno v:
Journal of Global Antimicrobial Resistance, Vol 29, Iss , Pp 468-475 (2022)
ABSTRACT: Objectives: In low–middle-income countries, increasing levels of HIV drug resistance (HIVDR) on second-line protease inhibitor (PI)-based regimens are a cause for concern given the limited drug options for third-line antiretroviral therap
Externí odkaz:
https://doaj.org/article/06c595bd500c4b65a557b119ab107495
Autor:
Kim Steegen, Gert U. van Zyl, Mathilda Claassen, Aabida Khan, Melendhran Pillay, Subitha Govender, Phillip A. Bester, Johanna M. van Straaten, Vibha Kana, Ewaldé Cutler, Monalisa N. Kalimashe, Ramokone L. Lebelo, Mokopi B. H. Moloi, Lucia Hans
Publikováno v:
Diagnostics, Vol 13, Iss 13, p 2209 (2023)
Monitoring of HIV drug resistance (HIVDR) remains critical for ensuring countries attain and sustain the global goals for ending HIV as a public health threat by 2030. On an individual patient level, drug resistance results assist in ensuring unneces
Externí odkaz:
https://doaj.org/article/fd7c7c92a9a2403ca4997f1fde063b85
Autor:
Pran Kishore Deb, Nizar A. Al-Shar’i, Katharigatta N. Venugopala, Melendhran Pillay, Pobitra Borah
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 869-884 (2021)
The alarming increase in multi- and extensively drug-resistant (MDR and XDR) strains of Mycobacterium tuberculosis (MTB) has triggered the scientific community to search for novel, effective, and safer therapeutics. To this end, a series of 3,5-disub
Externí odkaz:
https://doaj.org/article/b101f5f183424dad8acad9e590c3a69a
Autor:
Katharigatta N. Venugopala, Sandeep Chandrashekharappa, Pran Kishore Deb, Christophe Tratrat, Melendhran Pillay, Deepak Chopra, Nizar A. Al-Shar’i, Wafa Hourani, Lina A. Dahabiyeh, Pobitra Borah, Rahul D. Nagdeve, Susanta K. Nayak, Basavaraj Padmashali, Mohamed A. Morsy, Bandar E. Aldhubiab, Mahesh Attimarad, Anroop B. Nair, Nagaraja Sreeharsha, Michelyne Haroun, Sheena Shashikanth, Viresh Mohanlall, Raghuprasad Mailavaram
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1471-1486 (2021)
A series of 1,2,3-trisubstituted indolizines (2a–2f, 3a–3d, and 4a–4c) were screened for in vitro whole-cell anti-tubercular activity against the susceptible H37Rv and multidrug-resistant (MDR) Mycobacterium tuberculosis (MTB) strains. Compound
Externí odkaz:
https://doaj.org/article/317149f295104f1dbe7c0e6553495828
Autor:
Tamlyn A. Rautenberg, Shu Kay Ng, Gavin George, Mahomed-Yunus S. Moosa, Suzanne M. McCluskey, Rebecca F. Gilbert, Selvan Pillay, Isaac Aturinda, Kevin L. Ard, Winnie Muyindike, Nicholas Musinguzi, Godfrey Masette, Melendhran Pillay, Pravi Moodley, Jaysingh Brijkumar, Rajesh T. Gandhi, Brent Johnson, Henry Sunpath, Mwebesa B. Bwana, Vincent C. Marconi, Mark J. Siedner
Publikováno v:
Value in Health Regional Issues. 35:42-47