Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Melek Nihan, Ucisik"'
Autor:
Ravikumar Jimmidi, Srinivas Chamakuri, Shuo Lu, Melek Nihan Ucisik, Peng-Jen Chen, Kurt M. Bohren, Seyed Arad Moghadasi, Leroy Versteeg, Christina Nnabuife, Jian-Yuan Li, Xuan Qin, Ying-Chu Chen, John C. Faver, Pranavanand Nyshadham, Kiran L. Sharma, Banumathi Sankaran, Allison Judge, Zhifeng Yu, Feng Li, Jeroen Pollet, Reuben S. Harris, Martin M. Matzuk, Timothy Palzkill, Damian W. Young
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-10 (2023)
Abstract The development of SARS-CoV-2 main protease (Mpro) inhibitors for the treatment of COVID-19 has mostly benefitted from X-ray structures and preexisting knowledge of inhibitors; however, an efficient method to generate Mpro inhibitors, which
Externí odkaz:
https://doaj.org/article/aab44f4c21884a5ab19d7b954a87359d
Autor:
Ram K. Modukuri, Zhifeng Yu, Zhi Tan, Hai Minh Ta, Melek Nihan Ucisik, Zhuang Jin, Justin L. Anglin, Kiran L. Sharma, Pranavanand Nyshadham, Feng Li, Kevin Riehle, John C. Faver, Kevin Duong, Sureshbabu Nagarajan, Nicholas Simmons, Stephen S. Palmer, Mingxing Teng, Damian W. Young, Joanna S. Yi, Choel Kim, Martin M. Matzuk
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(22)
BRDT, BRD2, BRD3, and BRD4 comprise the bromodomain and extraterminal (BET) subfamily which contain two similar tandem bromodomains (BD1 and BD2). Selective BD1 inhibition phenocopies effects of tandem BET BD inhibition both in cancer models and, as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79a851d4e692ff7c8340bbbd30abba30
https://pubmed.ncbi.nlm.nih.gov/35622893
https://pubmed.ncbi.nlm.nih.gov/35622893
Autor:
Srinivas, Chamakuri, Shuo, Lu, Melek Nihan, Ucisik, Kurt M, Bohren, Ying-Chu, Chen, Huang-Chi, Du, John C, Faver, Ravikumar, Jimmidi, Feng, Li, Jian-Yuan, Li, Pranavanand, Nyshadham, Stephen S, Palmer, Jeroen, Pollet, Xuan, Qin, Shannon E, Ronca, Banumathi, Sankaran, Kiran L, Sharma, Zhi, Tan, Leroy, Versteeg, Zhifeng, Yu, Martin M, Matzuk, Timothy, Palzkill, Damian W, Young
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance SARS-CoV-2 has had a crippling impact on human life globally. Vaccine development has been used as a first-line strategy for COVID-19 prevention and mitigation; however, small-molecule drugs are still vitally needed to extend treatment o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::15cb54546b7f4431aeba52ef806a07ae
https://pubmed.ncbi.nlm.nih.gov/34426525
https://pubmed.ncbi.nlm.nih.gov/34426525