Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Melek Firat Altay"'
Autor:
Melek Firat Altay, Senthil T. Kumar, Johannes Burtscher, Somanath Jagannath, Catherine Strand, Yasuo Miki, Laura Parkkinen, Janice L. Holton, Hilal A. Lashuel
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-21 (2023)
Abstract The abnormal aggregation and accumulation of alpha-synuclein (aSyn) in the brain is a defining hallmark of synucleinopathies. Various aSyn conformations and post-translationally modified forms accumulate in pathological inclusions and vary i
Externí odkaz:
https://doaj.org/article/75e3ac5b75ef4930b6ce1a22c6cbcc54
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-18 (2022)
Abstract Alpha-synuclein (aSyn) is a pre-synaptic monomeric protein that can form aggregates in neurons in Parkinson’s disease (PD), Parkinson’s disease with dementia (PDD) and dementia with Lewy bodies (DLB), and in oligodendrocytes in multiple
Externí odkaz:
https://doaj.org/article/6103c9cd4bc2417fb7e51710ce817149
Autor:
Hilal A. Lashuel, Anne-Laure Mahul-Mellier, Salvatore Novello, Ramanath Narayana Hegde, Yllza Jasiqi, Melek Firat Altay, Sonia Donzelli, Sean M. DeGuire, Ritwik Burai, Pedro Magalhães, Anass Chiki, Jonathan Ricci, Manel Boussouf, Ahmed Sadek, Erik Stoops, Christian Iseli, Nicolas Guex
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-19 (2022)
Abstract Antibodies against phosphorylated alpha-synuclein (aSyn) at S129 have emerged as the primary tools to investigate, monitor, and quantify aSyn pathology in the brain and peripheral tissues of patients with Parkinson’s disease and other neur
Externí odkaz:
https://doaj.org/article/ccd4a55ef8a5402e84ee4c5adc02d9d4
Autor:
Melek Firat Altay, Senthil T. Kumar, Johannes Burtscher, Somanath Jagannath, Catherine Strand, Yasuo Miki, Laura Parkkinen, Janice L. Holton, Hilal A. Lashuel
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/2c0f9e4aea4c4551a955fc5dc5d2bcfc
Autor:
Berkiye Sonustun, Melek Firat Altay, Catherine Strand, Kirsten Ebanks, Geshanthi Hondhamuni, Thomas T. Warner, Hilal A. Lashuel, Rina Bandopadhyay
Publikováno v:
Cells, Vol 11, Iss 5, p 906 (2022)
Aggregated alpha-synuclein (α-synuclein) is the main component of Lewy bodies (LBs), Lewy neurites (LNs), and glial cytoplasmic inclusions (GCIs), which are pathological hallmarks of idiopathic Parkinson’s disease (IPD) and multiple system atrophy
Externí odkaz:
https://doaj.org/article/c09f6ecd7aea4af1a725ba337ebb3db0
Autor:
Melek Firat Altay, Senthil T. Kumar, Johannes Burtscher, Somanath Jagannath, Catherine Strand, Yasuo Miki, Laura Parkkinen, Janice L. Holton, Hilal A. Lashuel
The abnormal aggregation and accumulation of alpha-synuclein (aSyn) in the brain is a defining hallmark of synucleinopathies. An increasing number of studies show that aSyn in pathological aggregates exists as a complex mixture of various post-transl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53c3348c47316b3bbf3e837a75fb7fa3
https://doi.org/10.1101/2022.05.26.493598
https://doi.org/10.1101/2022.05.26.493598
Autor:
Hilal A. Lashuel, Anne-Laure Mahul-Mellier, Salvatore Novello, Ramanath Narayana Hegde, Yllza Jasiqi, Melek Firat Altay, Sonia Donzelli, Sean M. DeGuire, Ritwik Burai, Pedro Magalhães, Anass Chiki, Jonathan Ricci, Manel Boussouf, Ahmed Sadek, Erik Stoops, Christian Iseli, Nicolas Guex
Alpha-synuclein (aSyn) within Lewy bodies, Lewy neurites, and other pathological hallmarks of Parkinson’s disease and synucleinopathies have consistently been shown to accumulate in aggregated and phosphorylated forms of the protein, predominantly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ece1a363e47d9f98b078b7ec801c4b5b
https://doi.org/10.1101/2022.03.30.486322
https://doi.org/10.1101/2022.03.30.486322
Autor:
Nadine Ait-Bouziad, Niran Maharjan, Melek Firat Altay, Johannes Burtscher, Marie Croisier, Laura Weerens, Richard Wade-Martins, C Strand, Caroline Haikal, Anne-Laure Mahul-Mellier, Martin Citron, Romain Hamelin, Georges Mairet-Coello, Hilal A. Lashuel, Anass Chiki, Siv Vingill, Janice L. Holton, Graham Knott, Jia-Yi Li, Patrick Downey, Anne Michel
Although converging evidence point to alpha-synuclein (a-syn) aggregation and Lewy body (LB) formation as central events in Parkinson's disease (PD), the molecular mechanisms that regulate these processes and their role in disease pathogenesis remain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4517976da85ea71889fb8ca1c00979c9
https://doi.org/10.1101/500058
https://doi.org/10.1101/500058