Data on isoaspartylation of neuronal ELAVL proteins

Autor: Mario A. Pulido, Meleeneh Kazarian DerHartunian, Prerna Sehgal, Ite A. Laird-Offringa

Publikováno v: Data in Brief, Vol 9, Iss C, Pp 1052-1055 (2016)

This article contains experimental data examining the propensity of neuronal ELAVL proteins to become isoaspartylated. The data are related to the article “Isoaspartylation appears to trigger small cell lung cancer-associated autoimmunity against n

Externí odkaz: https://doaj.org/article/aca27798f2414f86b4c51da182c06ae8

Isoaspartylation appears to trigger small cell lung cancer-associated autoimmunity against neuronal protein ELAVL4

Autor: Stephen V. Liu, Jan J.G.M. Verschuuren, Diane Kang, Meleeneh Kazarian DerHartunian, Eric M. Chung, Zhenxia Qin, Andrew W. Woodham, W. Martin Kast, Mario A. Pulido, Lina Wang, Jeffrey A. Tsou, Ite A. Laird-Offringa, Rinse Klooster, Dana W. Aswad, Omid Akbari

Publikováno v: Journal of Neuroimmunology, 299, 70-78
Pulido, MA; DerHartunian, MK; Qin, Z; Chung, EM; Kang, DS; Woodham, AW; et al.(2016). Isoaspartylation appears to trigger small cell lung cancer-associated autoimmunity against neuronal protein ELAVL4. JOURNAL OF NEUROIMMUNOLOGY, 299, 70-78. doi: 10.1016/j.jneuroim.2016.09.002. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/43v5k0mg

Autoantibodies against SCLC-associated neuronal antigen ELAVL4 (HuD) have been linked to smaller tumors and improved survival, but the antigenic epitope and mechanism of autoimmunity have never been solved. We report that recombinant human ELAVL4 pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f56f236743df0aa4a26e228289e8356
http://hdl.handle.net/1887/112622

Low level anti-Hu reactivity: A risk marker for small cell lung cancer?

Autor: Meleeneh Kazarian, Ankur Patel, Ite A. Laird-Offringa, Janice S. Galler, Catherine L. Carpenter, Stephanie J. London, Jeffrey A. Tsou

Publikováno v: Cancer Detection and Prevention. 32:292-299

Background : Previous experimental and laboratory studies have implicated antibodies against Hu proteins (anti-Hu) as a potential marker for small cell lung cancer (SCLC); there are no estimates of the association between anti-Hu and SCLC using a pop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cec6d09f79bcfda563e8fb5c2d8f6264
https://doi.org/10.1016/j.cdp.2008.06.006

Immune response in lung cancer mouse model mimics human anti-Hu reactivity

Autor: Meleeneh Kazarian, Ite A. Laird-Offringa, Anton Berns, Natalie Proost, Joaquim Calbo, Catherine L. Carpenter

Publikováno v: Journal of neuroimmunology. 217(1-2)

Most patients with paraneoplastic encephalomyelitis/sensory neuronopathy PEM/SN have small-cell lung cancer (SCLC) and develop antibodies against neuronal-specific Hu proteins, which are abnormally expressed in the tumor. Anti-Hu reactivity is presen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d499a8c4bfbafc98df606483b58d63f4
https://pubmed.ncbi.nlm.nih.gov/19836087

Small-cell lung cancer-associated autoantibodies: potential applications to cancer diagnosis, early detection, and therapy

Autor: Ite A. Laird-Offringa, Meleeneh Kazarian

Publikováno v: Molecular Cancer, Vol 10, Iss 1, p 33 (2011)
Molecular Cancer

Small-cell lung cancer (SCLC) is the most aggressive lung cancer subtype and lacks effective early detection methods and therapies. A number of rare paraneoplastic neurologic autoimmune diseases are strongly associated with SCLC. Most patients with s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f825e0bc434d9b9204aafe870e721e2