Zobrazeno 1 - 10 of 120 pro vyhledávání: '"Meldgaard Lund, A"'
1
Akademický článek
Relationship between MAN2B1 genotype/subcellular localization subgroups, antidrug antibody detection, and long‐term velmanase alfa treatment outcomes in patients with alpha‐mannosidosis
Autor: Line Gutte Borgwardt, Ferdinando Ceravolo, Giulia Zardi, Andrea Ballabeni, Allan Meldgaard Lund
Publikováno v: JIMD Reports, Vol 64, Iss 2, Pp 187-198 (2023)
Abstract Alpha‐mannosidosis (AM), an autosomal recessive disorder caused by pathogenic biallelic variants in the MAN2B1 gene, leads to lysosomal alpha‐mannosidase deficiency and accumulation of mannose‐rich oligosaccharides. Velmanase alfa (VA)
Externí odkaz: https://doaj.org/article/70f1d07fdc024aabb477b895d1046324
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2
Akademický článek
Dose Finding in the Clinical Development of 60 US Food and Drug Administration–Approved Drugs Compared With Learning vs. Confirming Recommendations
Autor: Yassine Kamal Lyauk, Daniël Martijn Jonker, Trine Meldgaard Lund
Publikováno v: Clinical and Translational Science, Vol 12, Iss 5, Pp 481-489 (2019)
This review characterizes clinical development that supported the label dose in 60 drug indications recently approved by the US Food and Drug Administration. With Lewis B. Sheiner's Learning vs. Confirming clinical drug development paradigm as a refe
Externí odkaz: https://doaj.org/article/d316e312125c454daea3bc3bf94e500e
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3
Akademický článek
High-dose naloxone: Effects by late administration on pain and hyperalgesia following a human heat injury model. A randomized, double-blind, placebo-controlled, crossover trial with an enriched enrollment design.
Autor: Anders Deichmann Springborg, Elisabeth Kjær Jensen, Mads Kreilgaard, Morten Aagaard Petersen, Theodoros Papathanasiou, Trine Meldgaard Lund, Bradley Kenneth Taylor, Mads Utke Werner
Publikováno v: PLoS ONE, Vol 15, Iss 11, p e0242169 (2020)
Severe chronic postsurgical pain has a prevalence of 4-10% in the surgical population. The underlying nociceptive mechanisms have not been well characterized. Following the late resolution phase of an inflammatory injury, high-dose μ-opioid-receptor
Externí odkaz: https://doaj.org/article/6f867c45c1aa4cf7bf084c748ea69262
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4
Akademický článek
The impact of consanguinity on the frequency of inborn errors of metabolism
Autor: Raja Majid Afzal, Allan Meldgaard Lund, Flemming Skovby
Publikováno v: Molecular Genetics and Metabolism Reports, Vol 15, Iss , Pp 6-10 (2018)
Inborn errors of metabolism (IEM) are a heterogeneous group of genetic disorders present in all ethnic groups. We investigated the frequency of consanguinity among parents of newborns with IEM diagnosed by neonatal screening.Data were obtained from 1
Externí odkaz: https://doaj.org/article/f171be3b1a3046459428075c8e108ff5
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6
Akademický článek
Use of Molecular Genetic Analyses in Danish Routine Newborn Screening
Autor: Allan Meldgaard Lund, Flemming Wibrand, Kristin Skogstrand, Marie Bækvad-Hansen, Niels Gregersen, Brage Storstein Andresen, David M. Hougaard, Morten Dunø, Rikke Katrine Jentoft Olsen
Publikováno v: International Journal of Neonatal Screening, Vol 7, Iss 3, p 50 (2021)
Historically, the analyses used for newborn screening (NBS) were biochemical, but increasingly, molecular genetic analyses are being introduced in the workflow. We describe the application of molecular genetic analyses in the Danish NBS programme and
Externí odkaz: https://doaj.org/article/e2d3d02166b1482183928729f9ccf7df
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9
Artificial Neural Network vs. Pharmacometric Model for Population Prediction of Plasma Concentration in Real‐World Data: A Case Study on Valproic Acid
Autor: Hiie Soeorg, Eva Sverrisdóttir, Morten Andersen, Trine Meldgaard Lund, Maurizio Sessa
Publikováno v: Soeorg, H, Sverrisdóttir, E, Andersen, M, Lund, T M & Sessa, M 2022, ' Artificial neural network vs pharmacometric model for population prediction of plasma concentration in real-world data : a case study on valproic acid ', Clinical Pharmacology and Therapeutics, vol. 111, no. 6, pp. 1278-1285 . https://doi.org/10.1002/cpt.2577
We compared the predictive performance of an artificial neural network to traditional pharmacometric modeling for population prediction of plasma concentrations of valproate in real-world data. We included individuals aged 65 years or older with epil
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66445ad6cdcfc73aeff3ea5f9cafb92d
https://doi.org/10.1002/cpt.2577
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10
Akademický článek
Splenomegaly - Diagnostic validity, work-up, and underlying causes.
Autor: Emelie Curovic Rotbain, Dennis Lund Hansen, Ove Schaffalitzky de Muckadell, Flemming Wibrand, Allan Meldgaard Lund, Henrik Frederiksen
Publikováno v: PLoS ONE, Vol 12, Iss 11, p e0186674 (2017)
Our aim was to assess the validity of the ICD-10 code for splenomegaly in the Danish National Registry of Patients (DNRP), as well as to investigate which underlying diseases explained the observed splenomegaly.Splenomegaly is a common finding in pat
Externí odkaz: https://doaj.org/article/f6e6fceefc3744e6bc64a293f4114b42
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