2-(Fluoromethoxy)-4'-(

Autor: Javier, García-Cárceles, Henar, Vázquez-Villa, José, Brea, David, Ladron de Guevara-Miranda, Giovanni, Cincilla, Melchor, Sánchez-Martínez, Anabel, Sánchez-Merino, Sergio, Algar, María, Teresa de Los Frailes, Richard S, Roberts, Juan A, Ballesteros, Fernando, Rodríguez de Fonseca, Bellinda, Benhamú, María I, Loza, María L, López-Rodríguez

Publikováno v: Journal of medicinal chemistry. 65(18)

Tolerance development caused by dopamine replacement with l-DOPA and therapeutic drawbacks upon activation of dopaminergic receptors with orthosteric agonists reveal a significant unmet need for safe and effective treatment of Parkinson's disease. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6685ae066cdae21550a2a85ba88101c7
https://pubmed.ncbi.nlm.nih.gov/36044544

Novel Antagonist of the Type 2 Lysophosphatidic Acid Receptor (LPA

Autor: Nora, Khiar-Fernández, Debora, Zian, Henar, Vázquez-Villa, R Fernando, Martínez, Andrea, Escobar-Peña, Román, Foronda-Sainz, Manisha, Ray, Maria, Puigdomenech-Poch, Giovanni, Cincilla, Melchor, Sánchez-Martínez, Yasuyuki, Kihara, Jerold, Chun, Rubèn, López-Vales, María L, López-Rodríguez, Silvia, Ortega-Gutiérrez

Publikováno v: Journal of medicinal chemistry. 65(16)

Spinal cord injuries (SCIs) irreversibly disrupt spinal connectivity, leading to permanent neurological disabilities. Current medical treatments for reducing the secondary damage that follows the initial injury are limited to surgical decompression a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2c41a1fe7ad8b52b8d12e7964257e10c
https://pubmed.ncbi.nlm.nih.gov/35948083

The role of antibody responses against glycans in bioprosthetic heart valve calcification and deterioration

Autor: Thomas Senage, Anu Paul, Thierry Le Tourneau, Imen Fellah-Hebia, Marta Vadori, Salam Bashir, Manuel Galiñanes, Tomaso Bottio, Gino Gerosa, Arturo Evangelista, Luigi P. Badano, Alberto Nassi, Cristina Costa, Galli Cesare, Rizwan A. Manji, Caroline Cueff de Monchy, Nicolas Piriou, Romain Capoulade, Jean-Michel Serfaty, Guillaume Guimbretière, Etienne Dantan, Alejandro Ruiz-Majoral, Guénola Coste du Fou, Shani Leviatan Ben-Arye, Liana Govani, Sharon Yehuda, Shirley Bachar Abramovitch, Ron Amon, Eliran Moshe Reuven, Yafit Atiya-Nasagi, Hai Yu, Laura Iop, Kelly Casós, Sebastián G. Kuguel, Arnau Blasco-Lucas, Eduard Permanyer, Fabrizio Sbraga, Roger Llatjós, Gabriel Moreno-Gonzalez, Melchor Sánchez-Martínez, Michael E. Breimer, Jan Holgersson, Susann Teneberg, Marta Pascual-Gilabert, Alfons Nonell-Canals, Yasuhiro Takeuchi, Xi Chen, Rafael Mañez, Jean-Christian Roussel, Jean-Paul Soulillou, Emanuele Cozzi, Vered Padler-Karavani

Publikováno v: NATURE MEDICINE
Nature Medicine
Nature Medicine, 2022, Online ahead of print. ⟨10.1038/s41591-022-01682-w⟩
Nature medicine, vol 28, iss 2
Scientia

Outcomes research; Risk factors Investigación de resultados; Factores de riesgo Recerca dels resultats; Factors de risc Bioprosthetic heart valves (BHVs) are commonly used to replace severely diseased heart valves but their susceptibility to structu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3076c42c1c4820c95abd80bc2577948
https://pubmed.ncbi.nlm.nih.gov/35177855

Computer-Aided Drug Design (CADD) to De-Orphanize Marine Molecules: Finding Potential Therapeutic Agents for Neurodegenerative and Cardiovascular Diseases

Autor: Laura Llorach-Pares, Alfons Nonell-Canals, Conxita Avila, Melchor Sanchez-Martinez

Publikováno v: Marine Drugs, Vol 20, Iss 1, p 53 (2022)

Computer-aided drug design (CADD) techniques allow the identification of compounds capable of modulating protein functions in pathogenesis-related pathways, which is a promising line on drug discovery. Marine natural products (MNPs) are considered a

Externí odkaz: https://doaj.org/article/0e1b579d39304a188bc546d541d17b34

Metformin Is a Direct SIRT1-Activating Compound: Computational Modeling and Experimental Validation

Autor: Elisabet Cuyàs, Sara Verdura, Laura Llorach-Parés, Salvador Fernández-Arroyo, Jorge Joven, Begoña Martin-Castillo, Joaquim Bosch-Barrera, Joan Brunet, Alfons Nonell-Canals, Melchor Sanchez-Martinez, Javier A. Menendez

Publikováno v: Frontiers in Endocrinology, Vol 9 (2018)

Metformin has been proposed to operate as an agonist of SIRT1, a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase that mimics most of the metabolic responses to calorie restriction. Herein, we present an in silico analysis focusing on t

Externí odkaz: https://doaj.org/article/c7d9e1e1041d4fcb9bae970f349fbf99