Výsledky vyhledávání - "Melchner, Harald von"

CRISPR/Cas9 genome engineering in hematopoietic cells

Autor: Sürün, Duran, Melchner, Harald von, Schnütgen, Frank

The development of genome editing tools capable of modifying specific genomic sequences with unprecedented accuracy has opened up a wide range of new possibilities in targeted gene manipulation. In particular, the CRISPR/Cas9 system, a repurposed pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______603::1f5c6b913d40775871b60b882d809652
http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/51401

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Sestrin-2, a repressor of PDGFRβ signalling, promotes cigarette smokeinduced pulmonary emphysema in mice and is upregulated in patients with COPD

Autor: Heidler, Juliana, Fysikopoulos, Athanasios, Wempe, Frank, Seimetz, Michael, Bangsow, Thorsten, Tomasovic, Ana, Veit, Florian, Scheibe, Susan, Pichl, Alexandra, Weisel, Friederike, Lloyd, K. C. Kent, Jaksch, Peter, Klepetko, Walter, Weißmann, Norbert, Melchner, Harald von

Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. COPD is caused by chronic exposure to cigarette smoke and/or other environmental pollutants that are believed to induce reactive oxygen species (ROS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______603::a28582b6569cfa3495f468277f60d69c
http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/31650

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Die Zeit für die Zelle zurückdrehen : Reprogrammierung als Chance für die regenerative Medizin

Autor: Schnütgen, Frank, Melchner, Harald von

Einer der Träume der Medizin ist die Verwendung von Stammzellen als eine Art Ersatzteillager. Mit der Reprogrammierung differenzierter Zellen rückt dieser Traum, nicht abstoßbare, gesunde Organe zu erzeugen, ein Stück weiter in den Bereich des M�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______603::12ecb99f53189c001157200709ce435d
http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/31116

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Wnt/beta-catenin signaling controls development of the blood–brain barrier

Autor: Liebner, Stefan, Corada, Monica, Bangsow, Thorsten, Babbage, Jane, Taddei, Andrea, Czupalla, Cathrin Jacqueline, Reis, Marco, Felici, Angelina, Wolburg, Hartwig, Fruttiger, Marcus, Taketo, Makoto Mark, Melchner, Harald von (Prof. Dr.), Plate, Karl H., Gerhardt, Holger, Dejana, Elisabetta

The blood–brain barrier (BBB) is confined to the endothelium of brain capillaries and is indispensable for fluid homeostasis and neuronal function. In this study, we show that endothelial Wnt/beta-catenin (beta-cat) signaling regulates induction an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______603::baaf4f4a32272fe55071fabc877db3e7
http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/6712

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Gene trapping identifies transiently induced survival genes during programmed cell death

Autor: Wempe, Frank, Yang, Ji-Yeon, Hammann, Joanna, Melchner, Harald von (Prof. Dr.)

Background: The existence of a constitutively expressed machinery for death in individual cells has led to the notion that survival factors repress this machinery and, if such factors are unavailable, cells die by default. In many cells, however, mRN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______603::96fc241ee218b2e4d86479e82f64e73b
http://publikationen.ub.uni-frankfurt.de/files/4329/gb-2001-2-7-research0023.pdf

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Self-deleting vectors for gene therapy

Autor: Christoph Ebensperger, Thomas Andreu, Melchner Harald Von

Publikováno v: Biofutur. 1997:47

The invention relates to vectors for cancer therapy which as a result of genetic differences between normal and transformed cells selectively eliminate the latter. This is made possible by integrating a sequence-specific recombinase into a viral or n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::64cf97c9c05a57fd8e51f3000a45ac37
https://doi.org/10.1016/s0294-3506(99)80349-4

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Periodical

Disruption of genes regulated during hematopoietic differentiation of mouse embryonic stem cells

Autor: Muth, Katrin, Bruyns, Regina, Thorey, Irmgard S., Melchner, Harald von

Publikováno v: Developmental Dynamics; June 1998, Vol. 212 Issue: 2 p277-283, 7p

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Akademický článek

Gene trapping identifies a putative tumor suppressor and a new inducer of cell migration

Autor: Guardiola-Serrano, Francisca¹, Haendeler, Judith², Lukosz, Margarete², Sturm, Karsten¹, Melchner, Harald von¹, Altschmied, Joachim^1,2 Joachim.Altschmied@uni-duesseldorf.de

Publikováno v: Biochemical & Biophysical Research Communications. Nov2008, Vol. 376 Issue 4, p748-752. 5p.

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