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CRISPR/Cas9-mediated generation and analysis of N terminus polymorphic models of β 2 AR in isogenic hPSC-derived cardiomyocytes.

Autor: Kondrashov A; Division of Cancer and Stem Cells, University of Nottingham Biodiscovery Institute, University Park, Nottingham NG7 2RD, UK.; Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Midlands, UK., Mohd Yusof NAN; Division of Cancer and Stem Cells, University of Nottingham Biodiscovery Institute, University Park, Nottingham NG7 2RD, UK., Hasan A; National Heart and Lung Institute, Imperial College, London W12 0NN, UK., Goulding J; Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Midlands, UK.; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, UK., Kodagoda T; National Heart and Lung Institute, Imperial College, London W12 0NN, UK., Hoang DM; Division of Cancer and Stem Cells, University of Nottingham Biodiscovery Institute, University Park, Nottingham NG7 2RD, UK., Vo NTN; Division of Cancer and Stem Cells, University of Nottingham Biodiscovery Institute, University Park, Nottingham NG7 2RD, UK., Melarangi T; Division of Cancer and Stem Cells, University of Nottingham Biodiscovery Institute, University Park, Nottingham NG7 2RD, UK., Dolatshad N; National Heart and Lung Institute, Imperial College, London W12 0NN, UK., Gorelik J; National Heart and Lung Institute, Imperial College, London W12 0NN, UK., Hill SJ; Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Midlands, UK.; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, UK., Harding SE; National Heart and Lung Institute, Imperial College, London W12 0NN, UK., Denning C; Division of Cancer and Stem Cells, University of Nottingham Biodiscovery Institute, University Park, Nottingham NG7 2RD, UK.

Publikováno v: Molecular therapy. Methods & clinical development [Mol Ther Methods Clin Dev] 2020 Oct 27; Vol. 20, pp. 39-53. Date of Electronic Publication: 2020 Oct 27 (Print Publication: 2021).