Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Melany Jackson"'
Autor:
Melany Jackson, Rui Ma, A. Helen Taylor, Richard A. Axton, Jennifer Easterbrook, Maria Kydonaki, Emmanuel Olivier, Lamin Marenah, Edouard G. Stanley, Andrew G. Elefanty, Joanne C. Mountford, Lesley M. Forrester
Publikováno v:
Stem Cells Translational Medicine, Vol 5, Iss 8, Pp 981-990 (2016)
We have developed a robust, Good Manufacturing Practice‐compatible differentiation protocol capable of producing scalable quantities of red blood cells (RBCs) from human pluripotent stem cells (hPSCs). However, translation of this protocol to the c
Externí odkaz:
https://doaj.org/article/596957b1eb08495f81fa8f63b8c1c4b2
Autor:
Rui Ma, Maria Kydonaki, Melany Jackson, Jennifer Easterbrook, A. Helen Taylor, Joanne C. Mountford, Lesley M. Forrester, Lamin Marenah, Richard A Axton, Edouard G. Stanley, Emmanuel Olivier, Andrew G. Elefanty
Publikováno v:
Stem Cells Translational Medicine
Jackson, M, Ma, R, Taylor, A H, Axton, R A, Easterbrook, J, Kydonaki, M, Olivier, E, Marenah, L, Stanley, E G, Elefanty, A G, Mountford, J C & Forrester, L M 2016, ' Enforced Expression of HOXB4 in Human Embryonic Stem Cells Enhances the Production of Hematopoietic Progenitors but Has No Effect on the Maturation of Red Blood Cells ', Stem Cells Translational Medicine, vol. 5, no. 8, pp. 981-990 . https://doi.org/10.5966/sctm.2015-0324
Stem Cells Translational Medicine, Vol 5, Iss 8, Pp 981-990 (2016)
Jackson, M, Ma, R, Taylor, A H, Axton, R A, Easterbrook, J, Kydonaki, M, Olivier, E, Marenah, L, Stanley, E G, Elefanty, A G, Mountford, J C & Forrester, L M 2016, ' Enforced Expression of HOXB4 in Human Embryonic Stem Cells Enhances the Production of Hematopoietic Progenitors but Has No Effect on the Maturation of Red Blood Cells ', Stem Cells Translational Medicine, vol. 5, no. 8, pp. 981-990 . https://doi.org/10.5966/sctm.2015-0324
Stem Cells Translational Medicine, Vol 5, Iss 8, Pp 981-990 (2016)
Translation of a robust differentiation protocol capable of producing scalable quantities of red blood cells (RBCs) from human pluripotent stem cells to the clinic was compromised because the RBCs produced were not fully mature, expressed embryonic a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b17d23400e0d17927d03f1fa602ab3f
https://doi.org/10.5966/sctm.2015-0324
https://doi.org/10.5966/sctm.2015-0324
Publikováno v:
Stem Cell Research. 11(3):1273-1287
Notch signalling has been implicated during haematopoietic development in vivo and in the differentiation of haematopoietic cells from pluripotent cells in vitro. However interpretation of data from many of these studies has been complicated by the h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0d27da3ea343e13e0040e2d6a3ea3a2
Autor:
Lesley M. Forrester, Melany Jackson
Publikováno v:
STEM CELLS. 30:379-385
Pluripotent stem cells can be differentiated into hematopoietic lineages in vitro and hold promise for the future treatment of hematological disease. Differentiation strategies involving defined factors in serum-free conditions have been successful i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::624d875b172ed2df616ecc576373b01f
https://doi.org/10.1002/stem.1036
https://doi.org/10.1002/stem.1036
Autor:
Timothy Chevassut, Nick Gilbert, Anna Krassowska, Lesley M. Forrester, Bernard Ramsahoye, Melany Jackson, J. D. Ansell
Publikováno v:
Molecular and Cellular Biology. 24:8862-8871
It has been reported that DNA methyltransferase 1-deficient (Dnmt1−/−) embryonic stem (ES) cells are hypomethylated (20% CpG methylation) and die through apoptosis when induced to differentiate. Here, we show that Dnmt[3a−/−,3b−/−] ES cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0e234db257ff92928975eadbb072cfd
https://doi.org/10.1128/mcb.24.20.8862-8871.2004
https://doi.org/10.1128/mcb.24.20.8862-8871.2004
Autor:
Lesley M. Forrester, J. D. Ansell, Jennifer Nichols, Janet W. Baird, Melany Jackson, Gerry Graham, Ron Wilkie
Publikováno v:
Developmental Dynamics. 228:740-744
Ehox is an X-linked paired like homeobox gene identified from a differentiating embryonic stem (ES) cell cDNA library and is expressed at low levels in the preimplantation blastocyst and in ES cells in vitro. In embryos at 6.5 days post coitum (dpc),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6661e673d54c8fdf2ab933352dca48f
https://doi.org/10.1002/dvdy.10413
https://doi.org/10.1002/dvdy.10413
Autor:
Melany Jackson, Roderick C. McKenzie, Richard Weller, John A. A. Hunter, Elizabeth Sabin, Sarah E. M. Howie
Publikováno v:
The FASEB Journal. 13:495-502
Psoriasis is a chronic inflammatory dermatosis characterized by hyperproliferative keratinocytes (KC). The skin lesions are infiltrated by T cells, which secrete gamma interferon (gamma-IFN) and are believed to be necessary to maintain the psoriatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38d70ad8eb58fd85208acb6d0284aa44
https://doi.org/10.1096/fasebj.13.3.495
https://doi.org/10.1096/fasebj.13.3.495
Publikováno v:
Archives of Dermatological Research. 289:28-34
The persistence of human papillomavirus at cutaneous sites may be due to impaired trafficking of immune effector cells to the epidermis. We investigated whether HPV infection modulates cytokine mRNA expression in skin, thereby influencing local immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca203e9c8b9f4e0bd4ab191eaa6c148
https://doi.org/10.1007/s004030050148
https://doi.org/10.1007/s004030050148
Autor:
Nicholas L. Mills, John P. Iredale, Anna Hansen, Gareth J. Padfield, Olga Tura, David C. Hay, Kay Samuel, Marc Turner, Salvatore Pernagallo, Rong Zhang, Patrick W. F. Hadoke, Melany Jackson, Mei Wu, Mark Bradley, Juan J. Díaz-Mochón
Publikováno v:
Advanced healthcare materials. 1(5)
Rapid endothelisation is of critical importance in the prevention of adverse remodelling after device implantation. Currently, there is a need for alternative strategies to promote re-endothelialisation for intravascular stents and vascular grafts. U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a03a7bc5995928392ef0900e032a8417
https://pubmed.ncbi.nlm.nih.gov/23184801
https://pubmed.ncbi.nlm.nih.gov/23184801
Autor:
Oliver Hummel, A. Helen Taylor, Sabrina Gordon-Keylock, Herbert Schulz, Norbert Hubner, Melany Jackson, Julie Wilson, Konstantinos D. Kokkaliaris, Joshua M. Brickman, Lesley M. Forrester, Richard A Axton
Publikováno v:
Stem cells (Dayton, Ohio). 30(2)
Hematopoietic differentiation of embryonic stem cells (ESCs) in vitro has been used as a model to study early hematopoietic development, and it is well documented that hematopoietic differentiation can be enhanced by overexpression of HOXB4. HOXB4 is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3442d47342c76e7c58e5e9f0379b0268
https://pubmed.ncbi.nlm.nih.gov/22084016
https://pubmed.ncbi.nlm.nih.gov/22084016