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Heterogeneity in the Metastatic Microenvironment: JunB-Expressing Microglia Cells as Potential Drivers of Melanoma Brain Metastasis Progression.

Autor: Adir, Orit¹ (AUTHOR) oritadir@mail.tau.ac.il, Sagi-Assif, Orit¹ (AUTHOR) oritsa@tauex.tau.ac.il, Meshel, Tsipi¹ (AUTHOR) tzipi@tauex.tau.ac.il, Ben-Menachem, Shlomit¹ (AUTHOR) benmena@tauex.tau.ac.il, Pasmanik-Chor, Metsada² (AUTHOR) metsada@tauex.tau.ac.il, Hoon, Dave S. B.³ (AUTHOR) dave.hoon@providence.org, Witz, Isaac P.¹ (AUTHOR) isaacw@tauex.tau.ac.il, Izraely, Sivan¹ (AUTHOR) sivanisr@tauex.tau.ac.il

Publikováno v: Cancers. Oct2023, Vol. 15 Issue 20, p4979. 26p.

Correction to: Predictive value of perilesional edema volume in melanoma brain metastasis response to stereotactic radiosurgery.

Autor: Yavorska M; Unit of Radiation Oncology, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy., Tomaciello M; Radiation Oncology, Policlinico Umberto I, Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome, Italy., Sciurti A; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy., Cinelli E; Unit of Radiation Oncology, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy., Rubino G; Unit of Radiation Oncology, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy., Perrella A; Unit of Neuroradiology, Azienda Ospedaliero-Universitaria Senes, Siena, Italy., Cerase A; Unit of Neuroradiology, Azienda Ospedaliero-Universitaria Senes, Siena, Italy., Pastina P; Unit of Neuroradiology, Azienda Ospedaliero-Universitaria Senes, Siena, Italy., Gravina GL; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy., Arcieri S; Policlinico Umberto I Hospital, Viale del Policlinico, Rome, 00161, Italy., Mazzei MA; Unit of Diagnostic Imaging, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy., Migliara G; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy., Baccolini V; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy., Marampon F; Radiation Oncology, Policlinico Umberto I, Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome, Italy., Minniti G; Radiation Oncology, Policlinico Umberto I, Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome, Italy.; IRCSS Neuromed, Pozzilli, Italy., Di Giacomo AM; Center for Immuno-Oncology, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy., Tini P; Unit of Radiation Oncology, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy. paolo.tini@unisi.it.

Publikováno v: Journal of neuro-oncology [J Neurooncol] 2024 Dec; Vol. 170 (3), pp. 619.

HDAC8-mediated inhibition of EP300 drives a transcriptional state that increases melanoma brain metastasis

Autor: Michael F. Emmons, Richard L. Bennett, Alberto Riva, Kanchan Gupta, Larissa Anastasio Da Costa Carvalho, Chao Zhang, Robert Macaulay, Daphne Dupéré-Richér, Bin Fang, Edward Seto, John M. Koomen, Jiannong Li, Y. Ann Chen, Peter A. Forsyth, Jonathan D. Licht, Keiran S. M. Smalley

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)

Abstract Melanomas can adopt multiple transcriptional states. Little is known about the epigenetic drivers of these cell states, limiting our ability to regulate melanoma heterogeneity. Here, we identify stress-induced HDAC8 activity as driving melan

Externí odkaz: https://doaj.org/article/eaa6d6439c614e83a09975f61db4c4e0