Clinicopathologic characteristics of cutaneous melanoma - A single-center retrospective study

Autor: Jeremić Jelena, Jović Marko, Stojanović Marina, Mihaljević Jovan, Radenović Kristina, Radosavljević Ivan, Jovanović Milan

Publikováno v: Srpski Arhiv za Celokupno Lekarstvo, Vol 150, Iss 9-10, Pp 533-538 (2022)

Introduction/Objective. Epidemiology of melanoma including the number of new cases and mortality have been established in most developed countries, but data on pathohistological features are mostly missing. The objective of the study was to investiga

Externí odkaz: https://doaj.org/article/66da08804ac44c80b30cd16353c927c3

Real-world Outcomes of Ipilimumab Plus Nivolumab Combination Therapy in a Nation-wide Cohort of Advanced Melanoma Patients in the Netherlands

Autor: van Zeijl, Michiel C T, van Breeschoten, Jesper, de Wreede, Liesbeth C, Wouters, Michel W J M, Hilarius, Doranne L, Blank, Christian U, Aarts, Maureen J B, van den Berkmortel, Franchette W P J, de Groot, Jan Willem B, Hospers, Geke A P, Kapiteijn, Ellen, Piersma, Djura, van Rijn, Rozemarijn S, Stevense-den Boer, Marion A, van der Veldt, Astrid A M, Vreugdenhil, Gerard, Boers-Sonderen, Marye J, Suijkerbuijk, Karijn P M, Haanen, John B A G, van den Eertwegh, Alfons J M

Publikováno v: Journal of Immunotherapy (1997), 46, 197-204
van Zeijl, M C T, van Breeschoten, J, de Wreede, L C, Wouters, M W J M, Hilarius, D L, Blank, C U, Aarts, M J B, van den Berkmortel, F W P J, de Groot, J W B, Hospers, G A P, Kapiteijn, E, Piersma, D, van Rijn, R S, Stevense-den Boer, M A, van der Veldt, A A M, Vreugdenhil, G, Boers-Sonderen, M J, Suijkerbuijk, K P M, Haanen, J B A G & van den Eertwegh, A J M 2023, ' Real-world Outcomes of Ipilimumab Plus Nivolumab Combination Therapy in a Nation-wide Cohort of Advanced Melanoma Patients in the Netherlands ', Journal of Immunotherapy, vol. 46, no. 5, pp. 197-204 . https://doi.org/10.1097/CJI.0000000000000468
Journal of Immunotherapy (1997), 46, 5, pp. 197-204
Journal of Immunotherapy, 46(5), 197-204. Lippincott Williams and Wilkins
Journal of Immunotherapy, 46(5), 197-204. Lippincott Williams & Wilkins

Item does not contain fulltext In phase III trials, ipilimumab plus nivolumab combination therapy is highly efficacious for advanced melanoma, despite many treatment-related grades 3-4 adverse events. Here, we report real-world safety and survival ou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc5cae1f59afc7919e206ea2bb7ce20f
https://cris.maastrichtuniversity.nl/en/publications/0bab63c2-7c57-472e-b6fd-b12fcc4f0a81

Anatomic position determines oncogenic specificity in melanoma

Autor: Joshua M. Weiss, Miranda V. Hunter, Nelly M. Cruz, Arianna Baggiolini, Mohita Tagore, Yilun Ma, Sandra Misale, Michelangelo Marasco, Theresa Simon-Vermot, Nathaniel R. Campbell, Felicity Newell, James S. Wilmott, Peter A. Johansson, John F. Thompson, Georgina V. Long, John V. Pearson, Graham J. Mann, Richard A. Scolyer, Nicola Waddell, Emily D. Montal, Ting-Hsiang Huang, Philip Jonsson, Mark T.A. Donoghue, Christopher C. Harris, Barry S. Taylor, Tianhao Xu, Ronan Chaligné, Pavel V. Shliaha, Ronald Hendrickson, Achim A. Jungbluth, Cecilia Lezcano, Richard Koche, Lorenz Studer, Charlotte E. Ariyan, David B. Solit, Jedd D. Wolchok, Taha Merghoub, Neal Rosen, Nicholas K. Hayward, Richard M. White

Publikováno v: Weiss, J M, Hunter, M V, Cruz, N M, Baggiolini, A, Tagore, M, Ma, Y, Misale, S, Marasco, M, Simon-Vermot, T, Campbell, N R, Newell, F, Wilmott, J S, Johansson, P A, Thompson, J F, Long, G V, Pearson, J V, Mann, G J, Scolyer, R A, Waddell, N, Montal, E D, Huang, T H, Jonsson, P, Donoghue, M T A, Harris, C C, Taylor, B S, Xu, T, Chaligné, R, Shliaha, P V, Hendrickson, R, Jungbluth, A A, Lezcano, C, Koche, R, Studer, L, Ariyan, C E, Solit, D B, Wolchok, J D, Merghoub, T, Rosen, N, Hayward, N K & White, R M 2022, ' Anatomic position determines oncogenic specificity in melanoma ', Nature, vol. 604, pp. 354-361 . https://doi.org/10.1038/s41586-022-04584-6
Nature

Oncogenic alterations to DNA are not transforming in all cellular contexts1,2. This may be due to pre-existing transcriptional programmes in the cell of origin. Here we define anatomic position as a major determinant of why cells respond to specific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b39395de5cccb872bc76acd0f99b36d
https://portal.findresearcher.sdu.dk/da/publications/fc93f265-733a-47a2-81d0-e175a3bb1f60

Combined immune checkpoint inhibitor therapy with nivolumab and ipilimumab causing acute-onset type 1 diabetes mellitus following a single administration: two case reports

Autor: Marco Zezza, Nelly Pitteloud, Haithem Chtioui, Laura Marino, Faiza Lamine, Carine Mekoguem, Christophe Kosinski

Publikováno v: BMC Endocrine Disorders, Vol 19, Iss 1, Pp 1-5 (2019)
BMC Endocrine Disorders
BMC endocrine disorders, vol. 19, no. 1, pp. 144

BackgroundThe use of immune checkpoint inhibitor (ICI) therapy is becoming a standard of care for several cancers. Monoclonal antibodies targeting cytotoxic T-lymphocyte antigen-4 (CTLA-4) and programmed cell death protein 1 (PD-1) or its ligand (PD-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a722f98fa2436ff73199210f96e9153
https://doaj.org/article/5e85b5b762c841489b8519ccf9b5cc94

Tumor-associated factors are enriched in lymphatic exudate compared to plasma in metastatic melanoma patients

Autor: Aymeric Auger, Laura Santambrogio, Patricia Corthésy, Davide Demurtas, Emanuela Romano, Melody A. Swartz, Lambert Potin, Maurice Matter, Cristina C. Clement, Romain Hamelin, Alexandre Harari, Daniel E. Speiser, Natacha Bordry, Lea Maillat, Maria A. S. Broggi

Publikováno v: The Journal of Experimental Medicine
The Journal of experimental medicine, vol. 216, no. 5, pp. 1091-1107

Identifying cancer biomarkers is of great interest for patient prognosis and monitoring. However, tumor-associated factors are diluted in blood and challenging to detect. Broggi et al. show that lymphatic exudate, accessible at the time of lymphadene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18f6806c0790a1e5f776aeca52a5a9a1
http://europepmc.org/articles/PMC6504224