Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Melanie van der Woude"'
Autor:
Alba Muniesa-Vargas, Carlota Davó-Martínez, Cristina Ribeiro-Silva, Melanie van der Woude, Karen L. Thijssen, Ben Haspels, David Häckes, Ülkem U. Kaynak, Roland Kanaar, Jurgen A. Marteijn, Arjan F. Theil, Maayke M. P. Kuijten, Wim Vermeulen, Hannes Lans
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Congenital nucleotide excision repair (NER) deficiency gives rise to several cancer-prone and/or progeroid disorders. It is not understood how defects in the same DNA repair pathway cause different disease features and severity. Here, we sho
Externí odkaz:
https://doaj.org/article/93db3bf48b4e441887ae6a50279dcc97
Autor:
Charlotte Blessing, Katja Apelt, Diana van den Heuvel, Claudia Gonzalez-Leal, Magdalena B. Rother, Melanie van der Woude, Román González-Prieto, Adi Yifrach, Avital Parnas, Rashmi G. Shah, Tia Tyrsett Kuo, Daphne E. C. Boer, Jin Cai, Angela Kragten, Hyun-Suk Kim, Orlando D. Schärer, Alfred C. O. Vertegaal, Girish M. Shah, Sheera Adar, Hannes Lans, Haico van Attikum, Andreas G. Ladurner, Martijn S. Luijsterburg
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Cells employ global genome nucleotide excision repair to repair a broad spectrum of genomic DNA lesions. Here, the authors reveal how chromatin is primed for repair, providing insight into mechanisms of chromatin plasticity during DNA repair.
Externí odkaz:
https://doaj.org/article/ace7be3e1e274f3a94341103b43f7ce6
Autor:
Karen L. Thijssen, Melanie van der Woude, Carlota Davó-Martínez, Dick H. W. Dekkers, Mariangela Sabatella, Jeroen A. A. Demmers, Wim Vermeulen, Hannes Lans
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Hereditary mutations in TTDA/GTF2H5 cause a photosensitive form of the rare developmental disorder trichothiodystrophy, however the development of models has been hampered by mutations being lethal. Thijssen et al. show that deficiency of C. elegans
Externí odkaz:
https://doaj.org/article/aa9b284b2d79417c957d8200b1542823
Autor:
Melanie van der Woude, Hannes Lans
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100586- (2021)
Summary: Global genome nucleotide excision repair (GG-NER) and transcription-coupled nucleotide excision repair (TC-NER) protect cells against a variety of helix-distorting DNA lesions. In C. elegans, GG-NER primarily acts in proliferative germ cells
Externí odkaz:
https://doaj.org/article/b86e1105a5074d79a0ba547ada8dfb4f
Transcription-coupled nucleotide excision repair (TC-NER) is an important DNA repair mechanism that protects against the negative effects of transcription-blocking DNA lesions. Hereditary TC-NER deficiency causes pleiotropic and often severe neurodeg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be216f894d4bc5741d8dea56789a3d69
https://doi.org/10.1101/2023.01.24.525327
https://doi.org/10.1101/2023.01.24.525327
Autor:
Wenzhi Gong, Richard Mitter, Wim Vermeulen, Dalton A Plummer, Chirantani Mukherjee, Marvin van Toorn, Karel Bezstarosti, Jesper Q. Svejstrup, Arjan F. Theil, Arnab Ray Chaudhuri, Anja Raams, Melanie van der Woude, John J. Wyrick, René Bernards, Yannick P Kok, Marcel A. T. M. van Vugt, Jurgen A. Marteijn, Barbara Steurer, Simona Cugusi, Adriaan B Houtsmuller, Jeroen Demmers, Shisheng Li, Joyce H.G. Lebbink, Kathiresan Selvam, Bart Geverts, Hannes Lans, Roel C. Janssens, Marit E. Geijer, Di Zhou, Bastiaan Evers, Calvin Shun Yu Lo
Publikováno v:
Nature Cell Biology, 23(6), 608-619. Nature Publishing Group
Nature cell biology
Nat Cell Biol
Nature cell biology
Nat Cell Biol
Correct transcription is crucial for life. However, DNA damage severely impedes elongating RNA polymerase II, causing transcription inhibition and transcription-replication conflicts. Cells are equipped with intricate mechanisms to counteract the sev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c8be2132ea5385e582a7d0be3b3d819
https://doi.org/10.1038/s41556-021-00692-z
https://doi.org/10.1038/s41556-021-00692-z
Autor:
Dick H. W. Dekkers, Carlota Davó-Martínez, Karen L. Thijssen, Hannes Lans, Wim Vermeulen, Mariangela Sabatella, Jeroen Demmers, Melanie van der Woude
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Communications Biology
Communications Biology, 4(1):1336. Springer Nature
Communications Biology
Communications Biology, 4(1):1336. Springer Nature
The 10-subunit TFIIH complex is vital to transcription and nucleotide excision repair. Hereditary mutations in its smallest subunit, TTDA/GTF2H5, cause a photosensitive form of the rare developmental disorder trichothiodystrophy. Some trichothiodystr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aa5e73a379471a3cb271a6eb2e4d9cb
https://doi.org/10.1038/s42003-021-02875-8
https://doi.org/10.1038/s42003-021-02875-8
Autor:
Hannes Lans, Melanie van der Woude
Publikováno v:
STAR Protocols, 2(2):100586. Cell Press
STAR Protocols
STAR Protocols, Vol 2, Iss 2, Pp 100586-(2021)
STAR Protocols
STAR Protocols, Vol 2, Iss 2, Pp 100586-(2021)
Summary Global genome nucleotide excision repair (GG-NER) and transcription-coupled nucleotide excision repair (TC-NER) protect cells against a variety of helix-distorting DNA lesions. In C. elegans, GG-NER primarily acts in proliferative germ cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93c3151e5392af6510c8832bdd5f9add
https://pure.eur.nl/en/publications/4f51b285-5405-4399-aa7e-f5842a3404ec
https://pure.eur.nl/en/publications/4f51b285-5405-4399-aa7e-f5842a3404ec
Autor:
Melanie van der Woude, Wim Vermeulen, Hannes Lans, Mariangela Sabatella, Karen L. Thijssen, Carlota Davó-Martínez
The 10-subunit TFIIH complex is vital to both transcription initiation and nucleotide excision repair. Hereditary mutations in its smallest subunit, TTDA/GTF2H5, cause a photosensitive form of the rare developmental brittle hair disorder trichothiody
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd5d1937f527f7846a97cb787c257fc4
https://doi.org/10.1101/2021.06.04.447037
https://doi.org/10.1101/2021.06.04.447037
Autor:
Erik de Heuvel, Abhimanyu K. Singh, Ewald Edink, Tiffany van der Meer, Melanie van der Woude, Payman Sadek, Mikkel P. Krell-Jørgensen, Toine van den Bergh, Johan Veerman, Guy Caljon, Titilola D. Kalejaiye, Maikel Wijtmans, Louis Maes, Harry P. de Koning, Geert Jan Sterk, Marco Siderius, Iwan J.P. de Esch, David G. Brown, Rob Leurs
Publikováno v:
Bioorganic and Medicinal Chemistry, 27(18), 3998-4012. Elsevier Limited
de Heuvel, E, Singh, A K, Edink, E, van der Meer, T, van der Woude, M, Sadek, P, Krell-Jørgensen, M P, van den Bergh, T, Veerman, J, Caljon, G, Kalejaiye, T D, Wijtmans, M, Maes, L, de Koning, H P, Jan Sterk, G, Siderius, M, de Esch, I J P, Brown, D G & Leurs, R 2019, ' Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors ', Bioorganic and Medicinal Chemistry, vol. 27, no. 18, pp. 3998-4012 . https://doi.org/10.1016/j.bmc.2019.06.027
de Heuvel, E, Singh, A K, Edink, E, van der Meer, T, van der Woude, M, Sadek, P, Krell-Jørgensen, M P, van den Bergh, T, Veerman, J, Caljon, G, Kalejaiye, T D, Wijtmans, M, Maes, L, de Koning, H P, Jan Sterk, G, Siderius, M, de Esch, I J P, Brown, D G & Leurs, R 2019, ' Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors ', Bioorganic and Medicinal Chemistry, vol. 27, no. 18, pp. 3998-4012 . https://doi.org/10.1016/j.bmc.2019.06.027
Several 3',5'-cyclic nucleotide phosphodiesterases (PDEs) have been validated as good drug targets for a large variety of diseases. Trypanosoma brucei PDEB1 (TbrPDEB1) has been designated as a promising drug target for the treatment of human African
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7977de212c1b702b8e7a0a91b90f42f3
https://doi.org/10.1016/j.bmc.2019.06.027
https://doi.org/10.1016/j.bmc.2019.06.027