Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Melanie Z. Sakatis"'
Autor:
Ann M. Williams, Martin P. Vidgeon-Hart, Christopher A. Schofield, Metul Patel, Paul McGill, Carla F. Newman, Justyna M. Macina, Tracy Walker, Maxine A. Taylor, Melanie Z. Sakatis, Denise F. Vlachou
Publikováno v:
Chemical Research in Toxicology. 34:2485-2499
Drug-induced liver injury is a leading cause of compound attrition during both preclinical and clinical drug development, and early strategies are in place to tackle this recurring problem. Human-relevant in vitro models that are more predictive of h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d28a0d1ea9b48ae863da568dd1fc180
https://doi.org/10.1021/acs.chemrestox.1c00227
https://doi.org/10.1021/acs.chemrestox.1c00227
Development of an Improved T-cell Assay to Assess the Intrinsic Immunogenicity of Haptenic Compounds
Autor:
Joel Watkinson, Melanie Z. Sakatis, Monday O. Ogese, Brian Kevin Park, Dean J. Naisbitt, Adam Lister, Lee Faulkner, Andrew Gibson, Aimee Hillegas
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology
The prediction of drug hypersensitivity is difficult due to the lack of appropriate models and known risk factors. In vitro naïve T-cell priming assays that assess immunogenicity have been developed. However, their application is limited due require
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e56eca85252027716f1816875dba21e
Autor:
Jackie C. Bloomer, Melinda J. Reese, Stephen E. Clarke, Ian A. Baines, Cerys A. Lovatt, Andrew W Harrell, Jeffrey L. Ambroso, Liangfu Chen, Harma Ellens, Eric Yang, Melanie Z. Sakatis, Andrew Ayrton, Maxine A. Taylor
Publikováno v:
Chemical Research in Toxicology. 25:2067-2082
Drug-induced liver injury is the most common cause of market withdrawal of pharmaceuticals, and thus, there is considerable need for better prediction models for DILI early in drug discovery. We present a study involving 223 marketed drugs (51% assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92c08214c430cf0bef6e6d94714880e5
https://doi.org/10.1021/tx300075j
https://doi.org/10.1021/tx300075j
Autor:
Stephen E. Clarke, Melinda J. Reese, Ian A. Baines, Andrew W Harrell, Liangfu Chen, Melanie Z. Sakatis, Andy Ayrton, Lei Zhu, Jeffrey L. Ambroso, Eric Yang, Maxine A. Taylor
Publikováno v:
Chemico-Biological Interactions. 192:60-64
Metabolic bioactivation is widely considered an undesirable event and a likely prerequisite step in the expression of drug-induced hepatotoxicity and hypersensitivity. Reducing bioactivation risk early in drug discovery, therefore, may help reduce co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56710f9cc9a18734baa5bdb21f1ed538
https://doi.org/10.1016/j.cbi.2010.10.005
https://doi.org/10.1016/j.cbi.2010.10.005