Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Melanie Wurm"'
Autor:
Christiane Kofink, Nicole Trainor, Barbara Mair, Simon Wöhrle, Melanie Wurm, Nikolai Mischerikow, Michael J. Roy, Gerd Bader, Peter Greb, Géraldine Garavel, Emelyne Diers, Ross McLennan, Claire Whitworth, Vesna Vetma, Klaus Rumpel, Maximilian Scharnweber, Julian E. Fuchs, Thomas Gerstberger, Yunhai Cui, Gabriela Gremel, Paolo Chetta, Stefan Hopf, Nicole Budano, Joerg Rinnenthal, Gerhard Gmaschitz, Moriz Mayer, Manfred Koegl, Alessio Ciulli, Harald Weinstabl, William Farnaby
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Protein degraders are an emerging drug modality; however, their properties lie beyond typical drug-like space. Here the authors report optimisation via structure-based exit vector and linker design towards the VHL-recruiting PROTAC ACBI2, an orally b
Externí odkaz:
https://doaj.org/article/3f90550853c6402d8f154d10f8e2a18c
Autor:
Thomas Hoffmann, Alexandra Hörmann, Maja Corcokovic, Jakub Zmajkovic, Matthias Hinterndorfer, Jasko Salkanovic, Fiona Spreitzer, Anna Köferle, Katrin Gitschtaler, Alexandra Popa, Sarah Oberndorfer, Florian Andersch, Markus Schaefer, Michaela Fellner, Nicole Budano, Jan G Ruppert, Paolo Chetta, Melanie Wurm, Johannes Zuber, Ralph A Neumüller
Publikováno v:
eLife, Vol 12 (2023)
Loss-of-function genetic tools are widely applied for validating therapeutic targets, but their utility remains limited by incomplete on- and uncontrolled off-target effects. We describe artificial RNA interference (ARTi) based on synthetic, ultra-po
Externí odkaz:
https://doaj.org/article/5be3978b927a49d695b800fdcd6cb2bb
Autor:
Markus Zettl, Melanie Wurm, Otmar Schaaf, Sven Mostböck, Iñigo Tirapu, Ilse Apfler, Ivo C. Lorenz, Lee Frego, Cynthia Kenny, Michael Thibodeau, Elisa Oquendo Cifuentes, Markus Reschke, Jürgen Moll, Norbert Kraut, Anne Vogt, Jonathon D. Sedgwick, Irene C. Waizenegger
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Upregulation of inhibitory receptors, such as lymphocyte activation gene-3 (LAG-3), may limit the antitumor activity of therapeutic antibodies targeting the programmed cell death protein-1 (PD-1) pathway. We describe the binding properties of ezabenl
Externí odkaz:
https://doaj.org/article/84794c7453c64c359a1ba6066ae5ae77
Autor:
Adam Biddlecome, Habtom H Habte, Katherine M McGrath, Sharmila Sambanthamoorthy, Melanie Wurm, Martina M Sykora, Charles M Knobler, Ivo C Lorenz, Marcio Lasaro, Knut Elbers, William M Gelbart
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0215031 (2019)
Many mRNA-based vaccines have been investigated for their specific potential to activate dendritic cells (DCs), the highly-specialized antigen-presenting cells of the immune system that play a key role in inducing effective CD4+ and CD8+ T-cell respo
Externí odkaz:
https://doaj.org/article/63ad183a4d8846fdaac630f59f825b51
Autor:
Denis Delic, Fei Han, Jaume Capdevila, Katharina Reutner, Rachel Kroe-Barrett, Kai Bernd Stadermann, Aurelie Auguste, Anne Vogt, Isabella Alt, Christina Taubert, Irmgard Hofmann, Bruna de Andrade Pereira, Garazi Serna, Sven Mostböck, Paolo Nuciforo, Rajkumar Ganesan, Christina Pelster, Jark Böttcher, Paul Adam, Melanie Wurm, Otmar Schaaf
Publikováno v:
Molecular Cancer Therapeutics. 20:2250-2261
Despite some impressive clinical results with immune checkpoint inhibitors, the majority of patients with cancer do not respond to these agents, in part due to immunosuppressive mechanisms in the tumor microenvironment. High levels of adenosine in tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3d3156e387b668af620c58820f82109
https://doi.org/10.1158/1535-7163.mct-21-0107
https://doi.org/10.1158/1535-7163.mct-21-0107
Autor:
Harald Engelhardt, Daniel Gerlach, Anke Baum, Irene Waizenegger, Fabio Savarese, Dorothea Rudolph, Ulrike Tontsch-Grunt, Melanie Wurm, Norbert Schweifer, Norbert Kraut
Publikováno v:
Cancer Letters. 421:112-120
Interactions between a new potent Bromodomain and extraterminal domain (BET) inhibitor BI 894999 and the polo-like kinase (PLK) inhibitor volasertib were studied in acute myeloid leukemia cell lines in vitro and in vivo. We provide data for the disti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d415081278d8ff22820d89845d8fd4fb
https://doi.org/10.1016/j.canlet.2018.02.018
https://doi.org/10.1016/j.canlet.2018.02.018
Autor:
Ivo C. Lorenz, Marcio O. Lasaro, Habtom H. Habte, William M. Gelbart, Martina Sykora, Adam Biddlecome, Charles M. Knobler, Knut Elbers, Katherine M. McGrath, Melanie Wurm, Sharmila Sambanthamoorthy
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 6, p e0215031 (2019)
PLoS ONE, Vol 14, Iss 6, p e0215031 (2019)
Many mRNA-based vaccines have been investigated for their specific potential to activate dendritic cells (DCs), the highly-specialized antigen-presenting cells of the immune system that play a key role in inducing effective CD4+ and CD8+ T-cell respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7da9ececa74bef15345fb9008e99747c
https://doi.org/10.1371/journal.pone.0215031
https://doi.org/10.1371/journal.pone.0215031
Autor:
Michael S. Thibodeau, Markus Reschke, Jürgen Moll, Markus Zettl, Lee Frego, Elisa Oquendo Cifuentes, Eric Borges, Jonathon Sedgwick, Anne Vogt, Melanie Wurm, Otmar Schaaf, Iñigo Tirapu, Diann Blanset, Stephan-Michael Schmidbauer, Ivo C. Lorenz, Sven Mostböck, Norbert Kraut, Irene Waizenegger
Publikováno v:
Cancer Research. 78:4558-4558
The programmed cell death-1 (PD-1) receptor provides inhibitory checkpoint signals to activated T cells upon binding to its ligands, PD-L1 and PD-L2, which are expressed on antigen-presenting cells and cancer cells leading to suppression of T-cell ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e70379905a3dff0f81f077e32b2cd306
https://doi.org/10.1158/1538-7445.am2018-4558
https://doi.org/10.1158/1538-7445.am2018-4558
Autor:
Norbert Kraut, Jürgen Moll, Ivo C. Lorenz, Elisa Oquendo Cifuentes, Sven Mostböck, Markus Zettl, Markus Reschke, Diann Blanset, Eric Borges, Lee Frego, Melanie Wurm, Michael S. Thibodeau, Jonathon Sedgwick, Stephan-Michael Schmidbauer, Iñigo Tirapu, Irene Waizenegger, Anne Vogt, Otmar Schaaf
Publikováno v:
Cancer Research. 78:4547-4547
Lymphocyte activation gene-3 (LAG-3) is an inhibitory receptor involved in maintaining immunological tolerance via regulation of T-cell activation, proliferation and response. Ligand-mediated activation of LAG-3 negatively regulates T-cell activity t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::806042256c743cf9157727facd3fad3c
https://doi.org/10.1158/1538-7445.am2018-4547
https://doi.org/10.1158/1538-7445.am2018-4547
Autor:
Morten O. Christensen, Yves Pommier, Frank Essmann, Christian Mielke, Peter Schroeder, Constanze Wiek, Steffi Goffart, Fritz Boege, Ilaria Dalla Rosa, Helmut Hanenberg, Hongliang Zhang, Jean Krutmann, Klaus Schulze-Osthoff, Stefan Sobek, Melanie Wurm
Publikováno v:
Nucleic Acids Research
Topoisomerase I is essential for DNA metabolism in nuclei and mitochondria. In yeast, a single topoisomerase I gene provides for both organelles. In vertebrates, topoisomerase I is divided into nuclear and mitochondrial paralogs (Top1 and Top1mt). To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c69235c2e6c691e79782473b40083a36
https://doi.org/10.1093/nar/gkp708
https://doi.org/10.1093/nar/gkp708