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Autor:
Julia Kistner, Mariam Yazdanyar, Artur Lichtenberg, Ann Kathrin Bergmann, Payam Akhyari, Sarah Saradar, Alexander Jenke, Melanie Vera Rötepohl, Agunda Chekhoeva
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 319:H1123-H1141
Calcific aortic valve disease (CAVD) is characterized by valvular fibrosis and calcification and driven by differentiating valvular interstitial cells (VICs). Expression data from patient biopsies suggest that transforming growth factor (TGF)-β1 is