Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Melanie Vanessa Halbach"'
Autor:
Aleksandar Arsović, Melanie Vanessa Halbach, Júlia Canet-Pons, Dilhan Esen-Sehir, Claudia Döring, Florian Freudenberg, Nicoletta Czechowska, Kay Seidel, Stephan L. Baader, Suzana Gispert, Nesli-Ece Sen, Georg Auburger
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 18, p 6673 (2020)
Spinocerebellar ataxia type 2 (SCA2) is caused by polyglutamine expansion in Ataxin-2 (ATXN2). This factor binds RNA/proteins to modify metabolism after stress, and to control calcium (Ca2+) homeostasis after stimuli. Cerebellar ataxias and corticosp
Externí odkaz:
https://doaj.org/article/e9d428c64c004927914ea5f2ecf98dd6
Autor:
Melanie Vanessa Halbach, Tanja Stehning, Ewa Damrath, Marina Jendrach, Nesli Ece Şen, A Nazlı Başak, Georg Auburger
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121089 (2015)
The involvement of the ubiquitin-proteasome system (UPS) in the course of various age-associated neurodegenerative diseases is well established. The single RING finger type E3 ubiquitin-protein ligase PARK2 is mutated in a Parkinson's disease (PD) va
Externí odkaz:
https://doaj.org/article/a8b7e44dac9645efb768cd213579fb17
Autor:
Nesli-Ece Sen, Claudia Doering, Stéphane Dieterlé, R. Koenig, Suzana Gispert-Sanchez, Júlia Canet-Pons, Frédérique René, N. Hein-Fuchs, Anja Kerksiek, Melanie Vanessa Halbach, Aleksandar Arsovic, Gina Picchiarelli, D. Luetjohann, Jana Key, L.-E. Almaguer-Mederos, Raphaelle Cassel, Luc Dupuis, Georg Auburger
Publikováno v:
Neurobiology of Disease
Neurobiology of Disease, Elsevier, 2021, 152, pp.105289. ⟨10.1016/j.nbd.2021.105289⟩
Neurobiology of Disease, Vol 152, Iss, Pp 105289-(2021)
Neurobiology of Disease, 2021, 152, pp.105289. ⟨10.1016/j.nbd.2021.105289⟩
Neurobiology of disease, 152(2021):105289
Neurobiology of Disease, Elsevier, 2021, 152, pp.105289. ⟨10.1016/j.nbd.2021.105289⟩
Neurobiology of Disease, Vol 152, Iss, Pp 105289-(2021)
Neurobiology of Disease, 2021, 152, pp.105289. ⟨10.1016/j.nbd.2021.105289⟩
Neurobiology of disease, 152(2021):105289
Large polyglutamine expansions in Ataxin-2 (ATXN2) cause multi-system nervous atrophy in Spinocerebellar Ataxia type 2 (SCA2). Intermediate size expansions carry a risk for selective motor neuron degeneration, known as Amyotrophic Lateral Sclerosis (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab6de08db688b0e454f8807b9b1eac19
https://www.hal.inserm.fr/inserm-03376340/file/1-s2.0-S0969996121000383-main.pdf
https://www.hal.inserm.fr/inserm-03376340/file/1-s2.0-S0969996121000383-main.pdf
Autor:
Nesli-Ece Sen, Júlia Canet-Pons, Kay Seidel, Claudia Döring, Nicoletta Czechowska, Suzana Gispert, Aleksandar Arsovic, Florian Freudenberg, Melanie Vanessa Halbach, Georg Auburger, Dilhan Esen-Sehir, Stephan L. Baader
Spinocerebellar ataxia type 2 (SCA2) is caused by polyglutamine expansion in Ataxin-2 (ATXN2). This factor binds RNA/proteins to modify metabolism after stress, and to control calcium (Ca2+) homeostasis after stimuli, thus exerting crucial neuroprote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5095390ad27e48d827796d2f2f069c88
Autor:
Nesli-Ece Sen, Susanne Brodesser, Konrad Sandhoff, Melanie Vanessa Halbach, Júlia Canet-Pons, Carola Oberschmidt, Zeynep-Ece Kaya, Aleksandar Arsovic, David Meierhofer, Suzana Gispert, Georg Auburger
Ataxin-2 (ATXN2) acts during stress-responses, modulating mRNA translation and nutrient metabolism. Atxn2 knockout mice exhibit progressive obesity, dyslipidemia and insulin resistance. Conversely, the progressive ATXN2 gain-of-function due to polyGl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ea74764a16e7980f2fbdcd6bb505f7
Autor:
Georg Auburger, Susanne Brodesser, Zeynep-Ece Kaya, Júlia Canet-Pons, Aleksandar Arsovic, Carola Oberschmidt, Nesli-Ece Sen, Suzana Gispert, Konrad Sandhoff, Melanie-Vanessa Halbach, David Meierhofer
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 23, p 5854 (2019)
International Journal of Molecular Sciences
Volume 20
Issue 23
International Journal of Molecular Sciences
Volume 20
Issue 23
Ataxin-2 (human gene symbol ATXN2) acts during stress responses, modulating mRNA translation and nutrient metabolism. Ataxin-2 knockout mice exhibit progressive obesity, dyslipidemia, and insulin resistance. Conversely, the progressive ATXN2 gain of
Autor:
Melanie Vanessa Halbach, David Meierhofer, Júlia Canet-Pons, Ewa Rollmann, Georg Auburger, Nesli-Ece Sen, Suzana Gispert, Kay Seidel, Ulrich Pilatus, Laurens W. J. Bosman, Chris I. De Zeeuw, Aleksandar Arsovic, Woon-Hyung Chae, Michel Mittelbronn, Zeynep-Ece Kaya
Publikováno v:
Neurobiology of Disease, Vol 132, Iss, Pp-(2019)
Neurobiology of Disease, 132:104559. Academic Press
Neurobiology of Disease, 132. Academic Press
Neurobiology of Disease, 132:104559. Academic Press
Neurobiology of Disease, 132. Academic Press
Bosman, Laurens/0000-0001-9497-0566; Rollmann, Ewa/0000-0001-9777-4608 WOS:000497252500006 PubMed ID: 31376479 Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant neurodegenerative disorder caused by CAG-expansion mutations in the ATXN2 gen
Publikováno v:
Molecular & Cellular Proteomics. 15:1728-1739
Human Ataxin-2 (ATXN2) gene locus variants have been associated with obesity, diabetes mellitus type 1,and hypertension in genome-wide association studies, whereas mouse studies showed the knock-out of Atxn2 to lead to obesity, insulin resistance, an
Autor:
Michael Walter, Monica Fittschen, Georg Auburger, Suzana Gispert, Mekhman Azizov, Isabel Lastres-Becker, Sören Müller, Melanie Vanessa Halbach, Ewa Damrath
Publikováno v:
Neurogenetics
Digital.CSIC. Repositorio Institucional del CSIC
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Digital.CSIC. Repositorio Institucional del CSIC
instname
This article is distributed under the terms of the Creative Commons Attribution License.-- et al.
Spinocerebellar ataxia type 2 (SCA2) and amyotrophic lateral sclerosis (ALS) are neurodegenerative disorders, caused or modified by an unstable CAG
Spinocerebellar ataxia type 2 (SCA2) and amyotrophic lateral sclerosis (ALS) are neurodegenerative disorders, caused or modified by an unstable CAG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6d4b2667cb52406348e1e3d640ebd2d
http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/30633
http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/30633
Autor:
Melanie Vanessa Halbach, Ewa Damrath, Tanja Stehning, Georg Auburger, Michael Walter, Suzana Gispert
Publikováno v:
Cerebellum (London, England)
Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominantly inherited neurodegenerative disorder with preferential affection of Purkinje neurons, which are known as integrators of calcium currents. The expansion of a polyglutamine (polyQ) domain