Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Melanie Valenti"'
Autor:
Christopher I. Milton, Joanna Selfe, Ewa Aladowicz, Stella Y. K. Man, Carolina Bernauer, Edoardo Missiaglia, Zoë S. Walters, Susanne A. Gatz, Anna Kelsey, Melanie Generali, Gary Box, Melanie Valenti, Alexis deHaven‐Brandon, David Galiwango, Angela Hayes, Matthew Clarke, Elisa Izquierdo, David Gonzalez De Castro, Florence I. Raynaud, Vladimir Kirkin, Janet M. Shipley
Publikováno v:
Molecular Oncology, Vol 16, Iss 6, Pp 1272-1289 (2022)
Rhabdomyosarcomas are aggressive pediatric soft‐tissue sarcomas and include high‐risk PAX3–FOXO1 fusion‐gene‐positive cases. Fibroblast growth factor receptor 4 (FGFR4) is known to contribute to rhabdomyosarcoma progression; here, we sought
Externí odkaz:
https://doaj.org/article/5b496d1e847c44f09cabb855a8b74715
Autor:
Paul A Clarke, Maria-Jesus Ortiz-Ruiz, Robert TePoele, Olajumoke Adeniji-Popoola, Gary Box, Will Court, Stephanie Czasch, Samer El Bawab, Christina Esdar, Ken Ewan, Sharon Gowan, Alexis De Haven Brandon, Phillip Hewitt, Stephen M Hobbs, Wolfgang Kaufmann, Aurélie Mallinger, Florence Raynaud, Toby Roe, Felix Rohdich, Kai Schiemann, Stephanie Simon, Richard Schneider, Melanie Valenti, Stefan Weigt, Julian Blagg, Andree Blaukat, Trevor C Dale, Suzanne A Eccles, Stefan Hecht, Klaus Urbahns, Paul Workman, Dirk Wienke
Publikováno v:
eLife, Vol 5 (2016)
Mediator-associated kinases CDK8/19 are context-dependent drivers or suppressors of tumorigenesis. Their inhibition is predicted to have pleiotropic effects, but it is unclear whether this will impact on the clinical utility of CDK8/19 inhibitors. We
Externí odkaz:
https://doaj.org/article/a201fbf6b4ca430996a70dd003f4f498
Discovery of an In Vivo Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones
Autor:
Alice C. Harnden, Owen A. Davis, Gary M. Box, Angela Hayes, Louise D. Johnson, Alan T. Henley, Alexis K. de Haven Brandon, Melanie Valenti, Kwai-Ming J. Cheung, Alfie Brennan, Rosemary Huckvale, Olivier A. Pierrat, Rachel Talbot, Michael D. Bright, Hafize Aysin Akpinar, Daniel S. J. Miller, Dalia Tarantino, Sharon Gowan, Selby de Klerk, Peter Craig McAndrew, Yann-Vaï Le Bihan, Mirco Meniconi, Rosemary Burke, Vladimir Kirkin, Rob L. M. van Montfort, Florence I. Raynaud, Olivia W. Rossanese, Benjamin R. Bellenie, Swen Hoelder
Publikováno v:
Journal of Medicinal Chemistry. 66:5892-5906
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9094aa8cbb7b8cceb3273b677e3d3d9
https://doi.org/10.1021/acs.jmedchem.3c00155
https://doi.org/10.1021/acs.jmedchem.3c00155
Autor:
Florence I. Raynaud, Johann S. de Bono, Paul Workman, Stan B. Kaye, Suzanne A. Eccles, Bart Vanhaesebroeck, Mika Derynck, Lori Friedman, Richard D. Baird, Alexis de Haven Brandon, Gary Box, Melanie Valenti, Alan T. Henley, Yasmin J. Asad, Joo Chew Ang, Rupinder Pandher, Joo Ern Ang
Metabolite changes that constitute the Venn diagram in Figure 2. Significant changes listed are reductions (labelled "-1") or increases (labelled "1") in concentrations relative to the relevant controls.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35242fa0e3a742cbb6b034b2187e5495
https://doi.org/10.1158/1535-7163.22503601
https://doi.org/10.1158/1535-7163.22503601
Autor:
Chris Jones, Suzanne A. Eccles, Darren Hargrave, Francesco Hofmann, Florence I. Raynaud, Sebastien Jeay, Sharon Gowan, Sergey Popov, Alexa Jury, Vanessa Martins, Alexis de Haven Brandon, Melanie Valenti, Gary M. Box, Lara Perryman, Aleksandra Bielen
Pediatric glioblastoma (pGBM), although rare, is one of the leading causes of cancer-related deaths in children, with tumors essentially refractory to existing treatments. We have identified IGF1R to be a potential therapeutic target in pGBM due to g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::640aae47942f24340443cc8cc3e198f2
https://doi.org/10.1158/1535-7163.c.6535482
https://doi.org/10.1158/1535-7163.c.6535482
Autor:
Chris Jones, Suzanne A. Eccles, Darren Hargrave, Francesco Hofmann, Florence I. Raynaud, Sebastien Jeay, Sharon Gowan, Sergey Popov, Alexa Jury, Vanessa Martins, Alexis de Haven Brandon, Melanie Valenti, Gary M. Box, Lara Perryman, Aleksandra Bielen
Supplementary Figure 3 from Enhanced Efficacy of IGF1R Inhibition in Pediatric Glioblastoma by Combinatorial Targeting of PDGFRα/β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88ea1a0d2375245f2f675778fbd807ca
https://doi.org/10.1158/1535-7163.22497045
https://doi.org/10.1158/1535-7163.22497045
Autor:
Chris Jones, Suzanne A. Eccles, Darren Hargrave, Francesco Hofmann, Florence I. Raynaud, Sebastien Jeay, Sharon Gowan, Sergey Popov, Alexa Jury, Vanessa Martins, Alexis de Haven Brandon, Melanie Valenti, Gary M. Box, Lara Perryman, Aleksandra Bielen
Supplementary Figure 1 from Enhanced Efficacy of IGF1R Inhibition in Pediatric Glioblastoma by Combinatorial Targeting of PDGFRα/β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f1e2e83c50e82bfdffe58fedf9bc1cf
https://doi.org/10.1158/1535-7163.22497051
https://doi.org/10.1158/1535-7163.22497051
Autor:
Florence I. Raynaud, Johann S. de Bono, Paul Workman, Stan B. Kaye, Suzanne A. Eccles, Bart Vanhaesebroeck, Mika Derynck, Lori Friedman, Richard D. Baird, Alexis de Haven Brandon, Gary Box, Melanie Valenti, Alan T. Henley, Yasmin J. Asad, Joo Chew Ang, Rupinder Pandher, Joo Ern Ang
Summary of baseline reproducibility of candidate plasma metabolite biomarkers (n=17 patients).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca4f1e3fff57a56a184d3e834e92b978
https://doi.org/10.1158/1535-7163.22503598.v1
https://doi.org/10.1158/1535-7163.22503598.v1
Autor:
Florence I. Raynaud, Johann S. de Bono, Paul Workman, Stan B. Kaye, Suzanne A. Eccles, Bart Vanhaesebroeck, Mika Derynck, Lori Friedman, Richard D. Baird, Alexis de Haven Brandon, Gary Box, Melanie Valenti, Alan T. Henley, Yasmin J. Asad, Joo Chew Ang, Rupinder Pandher, Joo Ern Ang
Characteristics of dose-dependent changes in candidate plasma metabolite pharmacodynamic biomarker concentrations in 41 patients, as determined on day 1 of pictilisib clinical trial. Cells with p-values
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4068e9bc95db86ee6248750810664f56
https://doi.org/10.1158/1535-7163.22503595
https://doi.org/10.1158/1535-7163.22503595
Autor:
Michelle D. Garrett, Ian Collins, Paul Workman, Suzanne A. Eccles, Florence I. Raynaud, Wynne Aherne, Neil T. Thompson, John J. Caldwell, Gowri Vijayaraghavan, Lisa Pickard, Alan Henley, Simon P. Heaton, Ruth Ruddle, Paul D. Eve, Alexis de Haven Brandon, Melanie Valenti, Lisa-Jane K. Hunter, Mike I. Walton, Timothy A. Yap
Supplementary Figures 1-4 from Preclinical Pharmacology, Antitumor Activity, and Development of Pharmacodynamic Markers for the Novel, Potent AKT Inhibitor CCT128930
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::152e6b9e2a7c0fc3cf17558fd7b2c7b2
https://doi.org/10.1158/1535-7163.22496215.v1
https://doi.org/10.1158/1535-7163.22496215.v1