Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Melanie Spyra"'
Autor:
Melanie Spyra, Lan Kluwe, Christian Hagel, Rosa Nguyen, Jens Panse, Andreas Kurtz, Victor Felix Mautner, Samuel David Rabkin, Maria Demestre
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21099 (2011)
This study aims to examine whether or not cancer stem cells exist in malignant peripheral nerve sheath tumors (MPNST). Cells of established lines, primary cultures and freshly dissected tumors were cultured in serum free conditions supplemented with
Externí odkaz:
https://doaj.org/article/56228b24137f4c71855b377bafd5a182
Autor:
Yan Wang, Fricker Simon Paul, Kam Sprott, Philipp Uhlig, Kerstin David, Nicole Lange, Melanie Spyra
Publikováno v:
Journal of Histochemistry & Cytochemistry. 67:257-266
Chemokines and their receptors have been implicated in cancer biology. The CXCL12/CXCR4 axis is essential for the homing and retention of hematopoietic stem cells in bone marrow niches, and has a significant role in neonatal development. It is also i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c7183ff7d307143e748750ad86b17bc
https://doi.org/10.1369/0022155418818788
https://doi.org/10.1369/0022155418818788
Autor:
Wei Jiang, Johannes Salamon, Melanie Spyra, Florian Ewald, Daniel J Smit, Manfred Jücker, Victor-Felix Mautner, Alexander Schulte
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 4, p 1548 (2020)
Volume 21
Issue 4
International Journal of Molecular Sciences, Vol 21, Iss 4, p 1548 (2020)
Volume 21
Issue 4
Persistent signalling via the PI3K/AKT/mTOR pathway is a major driver of malignancy in NF1-associated malignant peripheral nerve sheath tumours (MPNST). Nevertheless, single targeting of this pathway is not sufficient to inhibit MPNST growth. In this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec06f99ba9b66b7049dcaca8d495e6a5
https://doi.org/10.3390/ijms21041548
https://doi.org/10.3390/ijms21041548
Publikováno v:
Genes, Chromosomes and Cancer. 54:482-488
Neurofibromatosis Type 2 (NF2) is an autosomal disorder caused by mutations of the NF2 gene. More than half of all NF2 patients have unaffected parents and carry de novo mutations, which may be of prezygotic or postzygotic origin. The latter can resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d098dd63cd38e25287e8c624d54febc
https://doi.org/10.1002/gcc.22259
https://doi.org/10.1002/gcc.22259
Autor:
Oksana Nemirovsky, Conxi Lázaro, Melanie Spyra, Kristi Allen, Lan Kluwe, Jonathan J Keats, Joan Castellsague, Christopher A. Maxwell, Alberto Villanueva, Sandra E. Dunn, Miguel Angel Pujana, Jihong Jiang, Kaiji Hu, Victor F. Mautner, Helen Chen, Pooja Mohan
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname
Oncotarget
ResearcherID
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname
Oncotarget
ResearcherID
Malignant peripheral nerve sheath tumours (MPNST) are rare, hereditary cancers associated with neurofibromatosis type I. MPNSTs lack effective treatment options as they often resist chemotherapies and have high rates of disease recurrence. Aurora kin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0855a578007020dadf9c0587e46f8677
https://doi.org/10.18632/oncotarget.793
https://doi.org/10.18632/oncotarget.793
Autor:
Melanie, Spyra, Benjamin, Otto, Gerhard, Schön, Hildegard, Kehrer-Sawatzki, Victor-Felix, Mautner
Publikováno v:
Genes, chromosomescancer. 54(8)
Neurofibromatosis Type 2 (NF2) is an autosomal disorder caused by mutations of the NF2 gene. More than half of all NF2 patients have unaffected parents and carry de novo mutations, which may be of prezygotic or postzygotic origin. The latter can resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6893f64c642d2656743e94a29ad1963b
https://pubmed.ncbi.nlm.nih.gov/26031996
https://pubmed.ncbi.nlm.nih.gov/26031996
Treatment of orthotopic malignant peripheral nerve sheath tumors with oncolytic herpes simplex virus
Autor:
Andreas Kurtz, Melanie Spyra, Victor F. Mautner, Robert L. Martuza, Slawomir Antoszczyk, Anat Stemmer-Rachamimov, Samuel D. Rabkin
Publikováno v:
Neuro-oncology. 16(8)
Backgrounds Malignant peripheral nerve sheath tumors (MPNSTs) are an aggressive and often lethal sarcoma that frequently develops in patients with neurofibromatosis type 1 (NF1). We developed new preclinical MPNST models and tested the efficacy of on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bbac7cfffebe527601fe0842e6e86d0
https://pubmed.ncbi.nlm.nih.gov/24470552
https://pubmed.ncbi.nlm.nih.gov/24470552
Autor:
Jacob, Gleiss, Maria, Demestre, Melanie, Spyra, Thomas, Eschenhagen, Christian, Hagel, Victor-F, Mautner, Lan, Kluwe, Reinhard E, Friedrich
Publikováno v:
In vivo (Athens, Greece). 27(6)
Xenografted benign tumours in immunodeficient mice provide an in vivo model to study tumour biology and the effect of agents on tumour growth. Conventionally, these small grafts can only be monitored upon sacrificing the animals. We evaluated ultraso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::61aa3d08719eaf00d51fb0b0ef7f19be
https://pubmed.ncbi.nlm.nih.gov/24292574
https://pubmed.ncbi.nlm.nih.gov/24292574
Autor:
Paul W. Manley, Christian Hagel, Melanie Spyra, Wei Jiang, Lan Kluwe, Claudia Schnabel, Reinhard E Friedrich, Victor-F. Mautner
Publikováno v:
Journal of neuro-oncology. 116(2)
Neurofibromatosis type 1 is a tumor suppressor gene disorder which predisposes patients to cutaneous neurofibromas, plexiform neurofibromas (PNFs) and malignant peripheral nerve sheath tumors (MPNSTs) among other neoplasias and manifestation. In this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9642fc5e55e2c1591de610d88bd87ee
https://pubmed.ncbi.nlm.nih.gov/24173684
https://pubmed.ncbi.nlm.nih.gov/24173684
Autor:
Tuba Esfandyari, Victor F. Mautner, Kaoru Terai, Luis F. Parada, Emma Borrego-Diaz, Amanda L. Wise, Sarah A. Taylor, Fariba Behbod, Faris Farassati, Melanie Spyra, Kristina Lialyte, Meena Upadhyaya
Publikováno v:
Journal of neuro-oncology. 108(3)
Cancer stem cells (CSCs) are believed to be the regenerative pool of cells responsible for repopulating tumors. Gaining knowledge about the signaling characteristics of CSCs is important for understanding the biology of tumors and developing novel an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38512d44a8148699a1df427181bc4f11
https://pubmed.ncbi.nlm.nih.gov/22484909
https://pubmed.ncbi.nlm.nih.gov/22484909