Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Melanie Sorensen"'
Autor:
PingHsun Hsieh, Vy Dang, Mitchell R. Vollger, Yafei Mao, Tzu-Hsueh Huang, Philip C. Dishuck, Carl Baker, Stuart Cantsilieris, Alexandra P. Lewis, Katherine M. Munson, Melanie Sorensen, AnneMarie E. Welch, Jason G. Underwood, Evan E. Eichler
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Duplications of gene segments can allow novel physiological adaptations to evolve. A detailed analysis of the TCAF gene family in primates and archaic humans suggest rapid duplication and diversification in this gene family is associated with cold or
Externí odkaz:
https://doaj.org/article/dd0c6ba953434ec38b1be1c12780fbb6
Autor:
Stuart Cantsilieris, Susan M. Sunkin, Matthew E. Johnson, Fabio Anaclerio, John Huddleston, Carl Baker, Max L. Dougherty, Jason G. Underwood, Arvis Sulovari, PingHsun Hsieh, Yafei Mao, Claudia Rita Catacchio, Maika Malig, AnneMarie E. Welch, Melanie Sorensen, Katherine M. Munson, Weihong Jiang, Santhosh Girirajan, Mario Ventura, Bruce T. Lamb, Ronald A. Conlon, Evan E. Eichler
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-35 (2020)
Abstract Background The complex interspersed pattern of segmental duplications in humans is responsible for rearrangements associated with neurodevelopmental disease, including the emergence of novel genes important in human brain evolution. We inves
Externí odkaz:
https://doaj.org/article/c298b2c7af2145a8892cd82025ceb851
Autor:
Flavia Angela Maria Maggiolini, Ludovica Mercuri, Francesca Antonacci, Fabio Anaclerio, Francesco Maria Calabrese, Nicola Lorusso, Alberto L’Abbate, Melanie Sorensen, Giuliana Giannuzzi, Evan E. Eichler, Claudia Rita Catacchio, Mario Ventura
Publikováno v:
Genes, Vol 11, Iss 2, p 213 (2020)
POTE (prostate, ovary, testis, and placenta expressed) genes belong to a primate-specific gene family expressed in prostate, ovary, and testis as well as in several cancers including breast, prostate, and lung cancers. Due to their tumor-specific exp
Externí odkaz:
https://doaj.org/article/1cad101bd7d84cd9b545bcf0d974f21c
Autor:
Melanie Sorensen, Yafei Mao, Sofie R. Salama, Claudia Rita Catacchio, Andy Wing Chun Pang, Françoise Thibaud-Nissen, Carl Baker, LaDeana W. Hillier, Ruiyang Li, Arvis Sulovari, Philip C. Dishuck, PingHsun Hsieh, Katherine M. Munson, Ludovica Mercuri, Jason D Fernandes, Jessica M. Storer, Joyce V. Lee, Benedict Paten, Mark A. Batzer, Peter A. Audano, David Porubsky, Tzu-Hsueh Huang, Jason G. Underwood, Evan E. Eichler, Jinna Hoffman, William T. Harvey, Kendra Hoekzema, Jerilyn A. Walker, Ian T. Fiddes, David Gordon, Marina Haukness, Alex Hastie, Alexandra P. Lewis, Francesca Antonacci, Mario Ventura, Shwetha C. Murali, Francesco Montinaro, Ilaria Piccolo, Mark Diekhans
Publikováno v:
Nature
The divergence of chimpanzee and bonobo provides one of the few examples of recent hominid speciation1,2. Here we describe a fully annotated, high-quality bonobo genome assembly, which was constructed without guidance from reference genomes by applyi
Nanopore sequencing and the Shasta toolkit enable efficient de novo assembly of eleven human genomes
Autor:
Karen H. Miga, Miten Jain, Simon Mayes, Kristof Tigyi, Kishwar Shafin, Benedict Paten, Nicholas Maurer, Ryan Lorig-Roach, Colleen M. Bosworth, Justin M. Zook, Duncan Kilburn, Hugh E. Olsen, Vania Costa, David Haussler, Kelvin J. Liu, Richard E. Green, Tobias Marschall, Melanie Sorensen, Paolo Carnevali, Sofie R. Salama, Erik Garrison, Mark Akeson, Marina Haukness, Mitchell R. Vollger, Katherine M. Munson, Fritz J. Sedlazeck, Adam M. Phillippy, Joel Armstrong, Jean Monlong, Sergey Koren, Evan E. Eichler, Trevor Pesout
Publikováno v:
Nature biotechnology, vol 38, iss 9
Nature Biotechnology
Nature biotechnology
Nature Biotechnology
Nature biotechnology
De novo assembly of a human genome using nanopore long-read sequences has been reported but it used more than 150,000 CPU hours and weeks of wall-clock time. To enable rapid human genome assembly we present Shasta, a de novo long read assembler, and
Autor:
Erik Bakkeren, Mélissa Caza, James W. Kronstad, Guanggan Hu, Linda C. Horianopoulos, Melanie Sorensen, Eddy Sánchez-León, Won Hee Jung
Publikováno v:
Cell Microbiol
The pathogenic fungus Cryptococcus neoformans must overcome iron limitation to cause disease in mammalian hosts. Previously, we reported a screen for insertion mutants with poor growth on haem as the sole iron source. In this study, we characterised
Autor:
Mitchell R. Vollger, Katherine M. Munson, Philip C. Dishuck, Vy Dang, Yafei Mao, PingHsun Hsieh, Tzu-Hsueh Huang, Melanie Sorensen, Alexandra P. Lewis, Carl Baker, AnneMarie E. Welch, Stuart Cantsilieris, Jason G. Underwood, Evan E. Eichler
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
TRP channel-associated factor 1/2 (TCAF1/TCAF2) proteins antagonistically regulate the cold-sensor protein TRPM8 in multiple human tissues. Understanding their significance has been complicated given the locus spans a gap-ridden region with complex s
Autor:
Evan E. Eichler, Richard K. Wilson, Vy Dang, Anne Marie E. Welch, Max L. Dougherty, Tina A. Graves-Lindsay, Philip C. Dishuck, Melanie Sorensen, Mark Chaisson, Mitchell R. Vollger
Publikováno v:
Nature methods
We have developed a computational method based on polyploid phasing of long sequence reads to resolve collapsed regions of segmental duplications within genome assemblies. Segmental Duplication Assembler (SDA; https://github.com/mvollger/SDA ) constr
Autor:
Peter Ebert, Peter A. Audano, Peter M. Lansdorp, Mark Chaisson, Maryam Ghareghani, Katherine M. Munson, Ashley D. Sanders, Charles Lee, Marina Haukness, Arvis Sulovari, Jana Ebler, Benedict Paten, Evan E. Eichler, Scott E. Devine, Jan O. Korbel, Melanie Sorensen, Tobias Marschall, William T. Harvey, David Porubsky, Mitchell R. Vollger, Pierre Marijon
Publikováno v:
Nature Biotechnology
Human genomes are typically assembled as consensus sequences that lack information on parental haplotypes. Here we describe a reference-free workflow for diploid de novo genome assembly that combines the chromosome-wide phasing and scaffolding capabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::664704a0641e287e772e1b3e41ea2b2c
http://edoc.mdc-berlin.de/19711/7/19711suppl.zip
http://edoc.mdc-berlin.de/19711/7/19711suppl.zip
Autor:
Yafei Mao, Alexandra M. Lewis, Mario Ventura, Vladimir Larionov, Tina A. Graves-Lindsay, Mikhail Liskovykh, Adam M. Phillippy, Evan E. Eichler, Philip C. Dishuck, Melanie Sorensen, Shwetha C. Murali, Urvashi Surti, Chirag Jain, David Porubsky, Andrey Bzikadze, Ludovica Mercuri, Glennis A. Logsdon, Karen H. Miga, PingHsun Hsieh, Sergey Koren, Milinn Kremitzki, Katherine M. Munson, Leonardo G. de Lima, Carl Baker, Arang Rhie, Jennifer L. Gerton, Mitchell R. Vollger, Sergey Nurk, Kendra Hoekzema
The complete assembly of each human chromosome is essential for understanding human biology and evolution. Using complementary long-read sequencing technologies, we complete the first linear assembly of a human autosome, chromosome 8. Our assembly re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e84b62a868220b1a2eb6d63ead72005
https://doi.org/10.1101/2020.09.08.285395
https://doi.org/10.1101/2020.09.08.285395