Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Melanie Scully"'
1
Rapid Estrogen Signaling Negatively Regulates PTEN Activity Through Phosphorylation in Endometrial Cancer Cells
Autor: Leslie K. Palacios-Helgeson, Melanie Scully, Lah S. Wah, Twila A. Jackson
Publikováno v: Hormones and Cancer. 5:218-231
Hyperestrogenicity is a risk factor for endometrial cancer. 17β-estradiol (E2) is known to stimulate both genomic and nongenomic estrogen receptor-α (ERα) actions in a number of reproductive tissues. However, the contributions of transcription-ind
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6987fc82efc36f92c0c1d491a0c5c589
https://doi.org/10.1007/s12672-014-0184-z
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2
HIF‐dependent regulation of AKAP12 (gravin) in the control of human vascular endothelial function
Autor: Louise E. Glover, Blair Fennimore, Eric L. Campbell, Sean P. Colgan, Melanie Scully, Thomas Weissmüller, Bryon Grove, Stefan F. Ehrentraut, Christopher F. MacManus, Valerie F. Curtis
Publikováno v: The FASEB Journal. 28:256-264
Hypoxia has been widely implicated in many pathological conditions, including those associated with inflammation and tumorigenesis. A number of recent studies have implicated hypoxia in the control of vasculogenesis and permeability, the basis for wh
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8bc086d0428244468da32292c403023
https://doi.org/10.1096/fj.13-238741
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3
Contribution of Adenosine A2B Receptors to Inflammatory Parameters of Experimental Colitis
Autor: Julia-Stefanie Frick, Louise E. Glover, Holger K. Eltzschig, Christopher F. MacManus, Sean P. Colgan, Melanie Scully
Publikováno v: The Journal of Immunology. 182:4957-4964
Inflammatory diseases influence tissue metabolism, significantly altering the profile of extracellular adenine nucleotides. A number of studies have suggested that adenosine (Ado) may function as an endogenously generated anti-inflammatory molecule.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97e8c4749d55eba914a5148702fc2d88
https://doi.org/10.4049/jimmunol.0801324
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4
Selective induction of integrin βi by hypoxia‐inducible factor: implications for wound healing
Autor: Melanie Scully, Louise E. Glover, Eric L. Campbell, Christopher F. MacManus, Sean P. Colgan, Simon Keely, Glenn T. Furuta
Publikováno v: The FASEB Journal. 23:1338-1346
Because of localized vascular damage and increased tissue oxygen demand, wound healing occurs in a relatively hypoxic microenvironment. These features are particularly relevant to wound healing and fibrosis in chronic inflammatory conditions, such as
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::69f6ec85cb0b13891e054eefefb7331d
https://doi.org/10.1096/fj.08-125344
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5
PMNs facilitate translocation of platelets across human and mouse epithelium and together alter fluid homeostasis via epithelial cell–expressed ecto-NTPDases
Autor: Eric L. Campbell, Glenn T. Furuta, Peter Rosenberger, Paul L. Beck, Sean P. Colgan, Melanie Scully, Thomas Weissmüller
Publikováno v: Journal of Clinical Investigation. 118:3682-3692
Mucosal diseases are often characterized by an inflammatory infiltrate that includes polymorphonuclear leukocytes (PMNs), monocytes, lymphocytes, and platelets. A number of studies have suggested that the interaction of platelets with leukocytes has
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3785764918fa466fb208d15fcb1603f9
https://doi.org/10.1172/jci35874
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6
An endogenously anti-inflammatory role for methylation in mucosal inflammation identified through metabolite profiling
Autor: Colm B. Collins, Melanie Scully, Louise E. Glover, Douglas J. Kominsky, Brittelle E. Bowers, Sean P. Colgan, Eric L. Campbell, Christopher F. MacManus, Simon Keely
Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 186(11)
Tissues of the mucosa are lined by an epithelium that provides barrier and transport functions. It is now appreciated that inflammatory responses in inflammatory bowel diseases are accompanied by striking shifts in tissue metabolism. In this paper, w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f35fb9dce426718809009f5d37a04f5e
https://pubmed.ncbi.nlm.nih.gov/21515785
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7
IFN-γ Attenuates Hypoxia-Inducible Factor (HIF) Activity in Intestinal Epithelial Cells through Transcriptional Repression of HIF-1β
Autor: Karina Irizarry, Louise E. Glover, Carol M. Aherne, Douglas J. Kominsky, Christopher F. MacManus, Brittelle E. Bowers, Melanie Scully, Eric L. Campbell, Sean P. Colgan
Numerous studies have revealed that hypoxia and inflammation occur coincidentally in mucosal disorders, such as inflammatory bowel disease. During inflammation, epithelial-expressed hypoxia-inducible factor (HIF) serves an endogenously protective fun
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8104e04746b56bff017ddf7ef1cd462
https://europepmc.org/articles/PMC4040106/
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10
Control of IFN-alphaA by CD73: implications for mucosal inflammation
Autor: Andreas Robinson, Nancy A. Louis, Jörn Karhausen, Melanie Scully, Sean P. Colgan, Christopher F. MacManus
Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 180(6)
Inflammatory diseases influence tissue metabolism, altering regulation of extracellular adenine nucleotides, with a resultant protective influence of adenosine. Ecto-5′-nucleotidase (CD73) is a central surface enzyme generating extracellular adenos
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aab7a17481211cda88e1bb90b83effa3
https://pubmed.ncbi.nlm.nih.gov/18322237
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