Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Melanie Scott"'
Autor:
Ulka Sachdev, Ricardo Ferrari, Xiangdong Cui, Abish Pius, Amrita Sahu, Michael Reynolds, Hong Liao, Ping Sun, Sunita Shinde, Fabrisia Ambrosio, Sruti Shiva, Patricia Loughran, Melanie Scott
Publikováno v:
Molecular Medicine, Vol 26, Iss 1, Pp 1-17 (2020)
Abstract Background We previously showed that the autophagy inhibitor chloroquine (CQ) increases inflammatory cleaved caspase-1 activity in myocytes, and that caspase-1/11 is protective in sterile liver injury. However, the role of caspase-1/11 in th
Externí odkaz:
https://doaj.org/article/80069bd5f95c4298bb6be131ec3912b7
Autor:
Guillaume Kraft, Melanie Scott, Eric Allen, Dale S. Edgerton, Ben Farmer, Bobak R. Azamian, Alan D. Cherrington
Publikováno v:
Physiological Reports, Vol 9, Iss 6, Pp n/a-n/a (2021)
Abstract The objective of this study was to assess the safety of surgical common hepatic artery denervation (CHADN). This procedure has previously been shown to improve glucose tolerance in dogs fed a high‐fat high‐fructose (HFHF) diet. We assess
Externí odkaz:
https://doaj.org/article/17b766eb1f7f4c01b67f37624d503b8e
Autor:
Ricardo Ferrari, Bowen Xie, Edwyn Assaf, Kristin Morder, Melanie Scott, Hong Liao, Michael J. Calderon, Mark Ross, Patricia Loughran, Simon C. Watkins, Iraklis Pipinos, George Casale, Edith Tzeng, Ryan McEnaney, Ulka Sachdev
Publikováno v:
Cells, Vol 11, Iss 7, p 1163 (2022)
Introduction: We previously showed that caspase-1 and -11, which are activated by inflammasomes, mediate recovery from muscle ischemia in mice. We hypothesized that similar to murine models, inflammatory caspases modulate myogenicity and inflammation
Externí odkaz:
https://doaj.org/article/a8eabaa588e9443c893796252bc27ca3
Autor:
Muhamuda Kader, Mounia Alaoui-El-Azher, Jennie Vorhauer, Bhushan B Kode, Jakob Z Wells, Donna Stolz, George Michalopoulos, Alan Wells, Melanie Scott, Nahed Ismail
Publikováno v:
PLoS Pathogens, Vol 13, Iss 10, p e1006644 (2017)
Severe hepatic inflammation is a common cause of acute liver injury following systemic infection with Ehrlichia, obligate Gram-negative intracellular bacteria that lack lipopolysaccharide (LPS). We have previously shown that type I IFN (IFN-I) and in
Externí odkaz:
https://doaj.org/article/f6fc2924cfa0408dae6cc05fe987328f
Autor:
Lara Hoteit, Patricia Loughran, Shannon Haldeman, Danielle Reiser, Nijmeh Alsaadi, Elizabeth Andraska, Jillian Bonaroti, Amudan Srinivasan, Kelly M. Williamson, Jurgis Alvikas, Richard Steinman, Joshua Keegan, James A. Lederer, Melanie Scott, Matthew D. Neal, Anupamaa Seshadri
Publikováno v:
Shock. 59:232-238
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3286bbe11499d18b80647d82c0068e41
https://doi.org/10.1097/shk.0000000000002033
https://doi.org/10.1097/shk.0000000000002033
Autor:
Guillaume Kraft, Katie C. Coate, Marta Smith, Ben Farmer, Melanie Scott, Jon Hastings, Alan D. Cherrington, Dale S. Edgerton
Publikováno v:
Diabetes. 72:196-209
Endogenous insulin secretion is a key regulator of postprandial hepatic glucose metabolism, but this process is dysregulated in diabetes. Subcutaneous insulin delivery alters normal insulin distribution, causing relative hepatic insulin deficiency an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4d1800212904726a665b8284e047a37
https://doi.org/10.2337/db22-0471
https://doi.org/10.2337/db22-0471
Publikováno v:
The Advocate. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::093a9ff425afc1737bd9e52345b16a7d
https://doi.org/10.4148/2637-4552.1171
https://doi.org/10.4148/2637-4552.1171
Autor:
DALE S. EDGERTON, GUILLAUME KRAFT, KATIE C. COATE, BEN FARMER, MARTA S. SMITH, MELANIE SCOTT, JON R. HASTINGS, MARY C. MOORE, ALAN D. CHERRINGTON
Publikováno v:
Diabetes. 71
High fat and fructose diets (HFFD) disrupt glucose metabolism. The aim of this study was to determine the effect of HFFD on glucagon (GGN) effectiveness. Dogs were fed either chow or HFFD for one month. After a basal sampling period, somatostatin and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ec96c910c1958597b705e0d3e142f41
https://doi.org/10.2337/db22-1341-p
https://doi.org/10.2337/db22-1341-p
Autor:
Ben Farmer, Phillip E. Williams, Marta S. Smith, Melanie Scott, Christina Pedersen, Guillaume Kraft, Alan D. Cherrington, L. Merkle Moore, David C. Laneve, Dale S. Edgerton
Publikováno v:
Am J Physiol Endocrinol Metab
Glucagon’s effect on hepatic glucose production (HGP), under hyperglycemic conditions, is time dependent such that after an initial burst of HGP, it slowly wanes. It is not known whether this is also the case under hypoglycemic conditions, where an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c725ee31f815aba172705e3e90fbd3ca
https://doi.org/10.1152/ajpendo.00466.2019
https://doi.org/10.1152/ajpendo.00466.2019
Autor:
Dale S. Edgerton, Bobak Robert Azamian, Anthony Vrba, Eric Allen, Scott Bradley Vafai, Guillaume Kraft, Alan D. Cherrington, Melanie Scott, Phil Williams
Publikováno v:
Diabetes
This study assessed the effectiveness of surgical sympathetic denervation of the common hepatic artery (CHADN) in improving glucose tolerance. CHADN eliminated norepinephrine content in the liver and partially decreased it in the pancreas and the upp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aae8ba595d7911951697392ab83834e
http://europepmc.org/articles/PMC6610023
http://europepmc.org/articles/PMC6610023