Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Melanie S. Glossop"'
Autor:
Stephen M. Shaw, Jenny Middleton, Kim Wigglesworth, Amber Charlemagne, Oliver Schulz, Melanie S. Glossop, Giles F. Whalen, Robert Old, Mike Westby, Chris Pickford, Rinat Tabakman, Irit Carmi-Levy, Abi Vainstein, Ella Sorani, Arik A. Zur, Sascha A. Kristian
Publikováno v:
Cancer Cell International, Vol 19, Iss 1, Pp 1-19 (2019)
Abstract Background Treatments that generate T cell-mediated immunity to a patient’s unique neoantigens are the current holy grail of cancer immunotherapy. In particular, treatments that do not require cumbersome and individualized ex vivo processi
Externí odkaz:
https://doaj.org/article/440a5a0ba0874d0aa71454cddd24f71c
Autor:
Abi Vainstein, Arik A. Zur, Ella Sorani, Giles F. Whalen, Jenny Middleton, Chris Pickford, Melanie S. Glossop, Robert Old, Oliver Schulz, Sascha A. Kristian, Irit Carmi-Levy, Amber Charlemagne, Mike Westby, Rinat Tabakman, Kim Wigglesworth, Stephen M. Shaw
Publikováno v:
Cancer Cell International, Vol 19, Iss 1, Pp 1-19 (2019)
Cancer Cell International
Cancer Cell International
BackgroundTreatments that generate T cell-mediated immunity to a patient’s unique neoantigens are the current holy grail of cancer immunotherapy. In particular, treatments that do not require cumbersome and individualized ex vivo processing or manu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a18846f7bb9b2696a1417608b07aba
https://doi.org/10.1186/s12935-019-1059-8
https://doi.org/10.1186/s12935-019-1059-8
Autor:
Mark L. Lewis, Charlotte Alice Louise Lane, Blanda Luzia Christa Stammen, David James Rawson, Peter J. Bungay, William A. Million, Stephen Martin Denton, Sharan K. Bagal, Tanya L. Hay, C. Elizabeth Payne, Lisa R. Thompson, Maw Graham Nigel, Cedric Poinsard, Karl Richard Gibson, Kemp Mark Ian, Edward B. Stevens, Melanie S. Glossop
Publikováno v:
ACS Medicinal Chemistry Letters. 6:650-654
Voltage-gated sodium channels, in particular Nav1.8, can be targeted for the treatment of neuropathic and inflammatory pain. Herein, we described the optimization of Nav1.8 modulator series to deliver subtype selective, state, and use-dependent chemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::498d91e57ef91a319caeeab504bffe20
https://doi.org/10.1021/acsmedchemlett.5b00059
https://doi.org/10.1021/acsmedchemlett.5b00059
Autor:
Ian B. Moses, M. Jonathan Fray, Adam T. Gillmore, Keith A. Reeves, Lisa R. Thompson, Melanie S. Glossop, David J. McManus, Céline F. B. Praquin
Publikováno v:
Organic Process Research & Development. 14:263-271
The development is described of a viable kilo-scale synthesis of the Nav1.8 sodium channel modulator, N-methyl-6-amino-5-(2,3,5-trichlorophenyl)pyridine-2-carboxamide (PF-1247324) in five steps, starting from 6-amino-5-bromo-2-picoline, in 33% overal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a356863667163c037ec41c1cc47c6278
https://doi.org/10.1021/op900092h
https://doi.org/10.1021/op900092h
Autor:
Dack Kevin Neil, Fox David Nathan Abraham, Strang Ross Sinclair, Dafydd R. Owen, Keith A. Reeves, Melanie S. Glossop, Graeme Arthur Macdonald, Christopher Phillips, Christine Anne Louise Watson, Mark Mills, Richard Bazin, Tracy J. Ringer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:3404-3406
Heteroarylalanine derivatives 4 were designed as potential inhibitors of neutral endopeptidase (NEP EC 3.4.24.11). Selectivity over other zinc metalloproteinases was explored through occupation of the S2′ subsite within NEP. Structural optimisation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5699785823bf7067227ef1f304784fa6
https://doi.org/10.1016/j.bmcl.2011.03.109
https://doi.org/10.1016/j.bmcl.2011.03.109
Autor:
Jenny Middleton, Kim Wigglesworth, Stephen M. Shaw, Chris Pickford, Robert Old, Mike Westby, Giles F. Whalen, Uri Galili, Melanie S. Glossop, Sascha A. Kristian
Publikováno v:
Journal of Clinical Oncology. 34:3083-3083
3083Background: Unlike virtually all non-primate mammals, humans lack α-Gal (Gal-α-1,3-Gal-β-1,4-GlcNAc) epitopes and produce antibodies against α-Gal-positive antigens. Anti-α-Gal (anti-Gal) antibodies are among the most abundant antibodies in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a3401bb53c59970b459d5bfbe2650f1
https://doi.org/10.1200/jco.2016.34.15_suppl.3083
https://doi.org/10.1200/jco.2016.34.15_suppl.3083
Autor:
Mark E. Bunnage, Melanie S. Glossop, David John Bull, Robert John Maguire, Dafydd R. Owen, Strang Ross Sinclair
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(1)
A suitable inhibitor of activated thrombin activatable fibrinolysis inhibitor (TAFIa) has the potential to be a novel treatment for thrombosis. The TAFIa inhibitor UK-396082 (1) was used as a starting point to seek more potent analogues. With knowled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ff1717c61331158a14e4a3ac71db8f1
https://pubmed.ncbi.nlm.nih.gov/19954973
https://pubmed.ncbi.nlm.nih.gov/19954973