Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Melanie S Vacchio"'
Autor:
Melanie S. Vacchio
Publikováno v:
T-Cell Development ISBN: 9781071627396
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c09f2218f2fcb70e868f1f18c54c4e35
https://doi.org/10.1007/978-1-0716-2740-2_10
https://doi.org/10.1007/978-1-0716-2740-2_10
Autor:
Melanie S, Vacchio
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2580
Expansion of T cell subsets in vitro is a valuable tool for exploration of effector function and differentiation. Here we provide protocols for in vitro differentiation of CD4 and CD8 T cell subsets from naïve T cells for functional studies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a7e6588f40a1b447a6a013283cb7bc19
https://pubmed.ncbi.nlm.nih.gov/36374457
https://pubmed.ncbi.nlm.nih.gov/36374457
Autor:
Michael C. Kelly, Dorian B. McGavern, Laura B. Chopp, Ting Chen, Thomas Ciucci, Melanie S. Vacchio, Jia Nie, Rémy Bosselut
Publikováno v:
The Journal of experimental medicine. 219(1)
During the immune response, CD4+ T cells differentiate into distinct effector subtypes, including follicular helper T (Tfh) cells that help B cells, and into memory cells. Tfh and memory cells are required for long-term immunity; both depend on the t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::981a12071e3d186a98968689a5f68a0a
https://pubmed.ncbi.nlm.nih.gov/34792529
https://pubmed.ncbi.nlm.nih.gov/34792529
Autor:
Golnaz Vahedi, Bao Tran, Marc K. Jenkins, Marion Pepper, Cameron McConkey, Yayi Gao, Mitchell T. McGinty, Rémy Bosselut, Masashi Watanabe, Mariah Balmaceno-Criss, Dorian B. McGavern, Yongmei Zhao, Qi Xiao, Melanie S. Vacchio, Allan Huang, Jyoti Shetty, Thomas Ciucci
Publikováno v:
Immunity
Summary The generation of high-affinity neutralizing antibodies, the objective of most vaccine strategies, occurs in B cells within germinal centers (GCs) and requires rate-limiting “help” from follicular helper CD4+ T (Tfh) cells. Although Tfh d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fafe552f485ee0c2d5fb2684192a3b62
https://pubmed.ncbi.nlm.nih.gov/31422869
https://pubmed.ncbi.nlm.nih.gov/31422869
Autor:
Yayi Gao, Monica Zamisch, Melanie S Vacchio, Elliott Paine, Gaelyn Lyons, Thomas Ciucci, Laura Chopp, Qi Xiao, Charles Vinson, Lisa Jenkins, Rémy Bosselut
Publikováno v:
The Journal of Immunology. 206:108.10-108.10
T cell precursors develop into helper CD4 or cytotoxic CD8 T cells in thymus. Thpok, a BTB/POZ family transcription factor, enforces MHC II restricted thymocytes commitment to the CD4 lineage, while Runx3 protein drives MHC I restricted thymocytes to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::915cb054ac1c833704bddbad3a912dc3
https://doi.org/10.4049/jimmunol.206.supp.108.10
https://doi.org/10.4049/jimmunol.206.supp.108.10
Autor:
Melanie S. Vacchio, Rémy Bosselut
Publikováno v:
The Journal of Immunology. 196:4848-4856
MHC-restricted CD4+ and CD8+ T cells are at the core of most adaptive immune responses. Although these cells carry distinct functions, they arise from a common precursor during thymic differentiation, in a developmental sequence that matches CD4 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c60b449ac028050cd0a58137225584d
https://doi.org/10.4049/jimmunol.1600415
https://doi.org/10.4049/jimmunol.1600415
Autor:
Thomas, Ciucci, Melanie S, Vacchio, Yayi, Gao, Francesco, Tomassoni Ardori, Julian, Candia, Monika, Mehta, Yongmei, Zhao, Bao, Tran, Marion, Pepper, Lino, Tessarollo, Dorian B, McGavern, Rémy, Bosselut
Publikováno v:
Immunity. 50(1)
Memory CD4(+) T cells mediate long term immunity, and their generation is a key objective of vaccination strategies. However, the transcriptional circuitry controlling the emergence of memory cells from early CD4(+) antigen-responders remains poorly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0fa6cdfd06140a6dae37cb081fcefb5c
https://pubmed.ncbi.nlm.nih.gov/30638736
https://pubmed.ncbi.nlm.nih.gov/30638736
Significance The acquisition of cytotoxic function by CD8 + T cells is critical for antiviral and antitumor responses. While cytotoxic differentiation is preprogrammed during CD8 + T-cell development in the thymus, the regulation of T-cell cytotoxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53fc1ad591fbcc040e7e76937ad65376
https://europepmc.org/articles/PMC5740647/
https://europepmc.org/articles/PMC5740647/
Autor:
Elizabeth A. Wohlfert, Andrea C. Carpenter, Melanie S. Vacchio, Yasmine Belkaid, Rémy Bosselut, Lie Wang, Nicolas Bouladoux, Paul E. Love, Yumei Xiong, Ki-Duk Song, Linus C. Williams
Publikováno v:
Nature immunology
The transcription factor ThPOK promotes CD4(+) T cell differentiation in the thymus. Here, using a mouse strain that allows post-thymic gene deletion, we show that ThPOK maintains CD4(+) T lineage integrity and couples effector differentiation to env
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3429b671803e4645b344cd2e1a695b49
http://europepmc.org/articles/PMC4251968
http://europepmc.org/articles/PMC4251968
Autor:
Rémy Bosselut, Melanie S. Vacchio
Publikováno v:
Methods in Molecular Biology ISBN: 9781493928088
T-Cell Development
T-Cell Development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb33e1db23f211a4c4a909b19972e1c4
https://doi.org/10.1007/978-1-4939-2809-5
https://doi.org/10.1007/978-1-4939-2809-5