Výsledky vyhledávání - "Melanie S, Flint"

Akademický článek

Multiple TLRs elicit alternative NLRP3 inflammasome activation in primary human monocytes independent of RIPK1 kinase activity

Autor: Sarah Unterberger, Lisa Mullen, Melanie S. Flint, Sandra Sacre

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

The canonical NOD-like receptor family pyrin domain containing 3 (NLRP3) pathway involves a priming step to induce pro-IL-1β followed by a secondary signal such as K+ efflux to activate inflammasome formation. This then leads to the maturation of IL

Externí odkaz: https://doaj.org/article/5cd1a8c0fbcc4e3a85acdbbdd2a06345

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Akademický článek

An integrated framework for quantifying immune-tumour interactions in a 3D co-culture model

Autor: Gheed Al-Hity, FengWei Yang, Eduard Campillo-Funollet, Andrew E. Greenstein, Hazel Hunt, Myrthe Mampay, Haya Intabli, Marta Falcinelli, Anotida Madzvamuse, Chandrasekhar Venkataraman, Melanie S. Flint

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)

Al-Hity et al present a platform to study the tumour-immune interaction using a co-culture between cancer spheroids and activated immune cells. They assess the effects of cortisol application to the culture model as proof-of-concept, which demonstrat

Externí odkaz: https://doaj.org/article/c934dd548ce34df6a207a29ad10e6bef

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Akademický článek

Thermoregulation is not impaired in breast cancer survivors during moderate‐intensity exercise performed in warm and hot environments

Autor: Rebecca L. Relf, Ben J. Lee, Gregor Eichhorn, Melanie S. Flint, Louisa Beale, Neil Maxwell

Publikováno v: Physiological Reports, Vol 9, Iss 14, Pp n/a-n/a (2021)

Abstract This study aimed to assess how female breast cancer survivors (BCS) respond physiologically, hematologically, and perceptually to exercise under heat stress compared to females with no history of breast cancer (CON). Twenty‐one females (9

Externí odkaz: https://doaj.org/article/4c8dc6a5cf6848c6bdc2cd34582f5268

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The Genotoxicity of Stress

Autor: Renée L. Flaherty, Melanie S. Flint

Publikováno v: Chemical Research in Toxicology. 36:129-131

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::af128eb45c22d835d9ddeaf6f69aa540
https://doi.org/10.1021/acs.chemrestox.2c00336

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Supplementary Table 1 from Erlotinib, Erlotinib–Sulindac versus Placebo: A Randomized, Double-Blind, Placebo-Controlled Window Trial in Operable Head and Neck Cancer

Autor: Jennifer R. Grandis, Jill M. Siegfried, Marina N. Nikiforova, Lori Wirth, Athanassios Argiris, Seungwon Kim, Jonas T. Johnson, Robert L. Ferris, Thomas P. Conrads, Mai Sun, Melanie S. Flint, Brian L. Hood, Simion Chiosea, Lin Wang, Sufi M. Thomas, William Denq, William E. Gooding, Julie E. Bauman, Neil D. Gross

PDF file - 61KB, Antibodies used to evaluate candidate biomarkers in the TMA.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::297df181be05d555f505b65300e6f485
https://doi.org/10.1158/1078-0432.22457430

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Supplementary Figure 2 from Erlotinib, Erlotinib–Sulindac versus Placebo: A Randomized, Double-Blind, Placebo-Controlled Window Trial in Operable Head and Neck Cancer

PDF file - 148KB, Exploratory Baseline Analytes.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0706d6ffc4b3c295c9635bda45816ef
https://doi.org/10.1158/1078-0432.22457433

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Data from Erlotinib, Erlotinib–Sulindac versus Placebo: A Randomized, Double-Blind, Placebo-Controlled Window Trial in Operable Head and Neck Cancer

Purpose: The EGF receptor (EGFR) and COX2 pathways are upregulated in head and neck squamous cell carcinoma (HNSCC). Preclinical models indicate synergistic antitumor activity from dual blockade. We conducted a randomized, double-blind, placebo-contr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d614bb3fe8eccd43fe587579b5e7408
https://doi.org/10.1158/1078-0432.c.6523575

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Supplementary Figure 1 from Erlotinib, Erlotinib–Sulindac versus Placebo: A Randomized, Double-Blind, Placebo-Controlled Window Trial in Operable Head and Neck Cancer

PDF file - 176KB, Assessing the Adequacy of Randomization.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::431ec6a6b837e9e3e3e76f6b58b15130
https://doi.org/10.1158/1078-0432.22457436.v1

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The Role of Psychologic Stress in Cancer Initiation: Clinical Relevance and Potential Molecular Mechanisms

Autor: Melanie S. Flint, Marta Falcinelli, Susan K. Lutgendorf, Suzanne D. Conzen, Premal H. Thaker, Renée L. Flaherty

Publikováno v: Cancer Res

The hypothesis that the physiologic response to psychologic stress influences the initiation of cancer is highly controversial. The link between initiating stressors, the psychologic stress response, and disease is plausible, considering that the str

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::012cb6e247e8fda9b57e32b55b2c16a6
https://doi.org/10.1158/0008-5472.can-21-0684

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Akademický článek

Proteomic Analysis of Matched Formalin-Fixed, Paraffin-Embedded Specimens in Patients with Advanced Serous Ovarian Carcinoma

Autor: Ashlee L. Smith, Mai Sun, Rohit Bhargava, Nicolas A. Stewart, Melanie S. Flint, William L. Bigbee, Thomas C. Krivak, Mary A. Strange, Kristine L. Cooper, Kristin K. Zorn

Publikováno v: Proteomes, Vol 1, Iss 3, Pp 240-253 (2013)

Objective: The biology of high grade serous ovarian carcinoma (HGSOC) is poorly understood. Little has been reported on intratumoral homogeneity or heterogeneity of primary HGSOC tumors and their metastases. We evaluated the global protein expression

Externí odkaz: https://doaj.org/article/ae3d373c0eb04989a1c51a1be8d1f77e

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