Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Melanie Rothe"'
Autor:
Monika Kustermann, Svenja Laue, Yinghong Cui, Douglas G. Tilley, Laurel A. Grisanti, Melanie Rothe, Michael Kauk, Carsten Hoffmann, Melanie Philipp, WH Zimmermann, Teresa Casar Tena, Allessandra Moretti, Farah Raad, Michael Kühl, Martina S. Burczyk, Sabrina Matysik, Martin D. Burkhalter, Cornelia Donow, Jürgen Wess
Publikováno v:
JCI Insight
Deterioration or inborn malformations of the cardiac conduction system (CCS) interfere with proper impulse propagation in the heart and may lead to sudden cardiac death or heart failure. Patients afflicted with arrhythmia depend on antiarrhythmic med
Autor:
Melanie Rothe, Michael Kühl, Gerhard Mittler, Patrick Rodriguez, Nassif Tabaja, Rhett A. Kovall, Franz Oswald, Kelly J. Collins, Tilman Borggrefe, Laura Mira, Kerstin Hein, Verena N. Thiel, Susanne J. Kühl, Benedetto Daniele Giaimo, Maria Dominguez, Wiebke Cizelsky, Zeus A. Antonello, Francesca Ferrante
Publikováno v:
Nucleic Acids Research (London)
Nucleic Acids Research
Nucleic Acids Research
The transcriptional shift from repression to activation of target genes is crucial for the fidelity of Notch responses through incompletely understood mechanisms that likely involve chromatin-based control. To activate silenced genes, repressive chro
Autor:
Karl-Ludwig Laugwitz, Alessandra Moretti, Seppo Vainio, Michael Kühl, Alexander Linnemann, Yanchun Guo, Susanne J. Kühl, Astrid S. Pfister, Tatjana Dorn, Melanie Rothe
Publikováno v:
Developmental Biology
Wnt proteins can activate different intracellular signaling pathways. These pathways need to be tightly regulated for proper cardiogenesis. The canonical Wnt/β-catenin inhibitor Dkk1 has been shown to be sufficient to trigger cardiogenesis in gain-o
Autor:
Juergen Bockmann, Michael Kühl, Tobias M. Boeckers, Annemarie Hempel, Noreen Kanwal, Rebecca Engels, Melanie Rothe, Susanne J. Kühl, Desiree Schütz, Dominik Reim, Petra Dietmann, Alexander Linnemann, Franziska A. Seigfried, Michael J. Schmeisser
Publikováno v:
Development (Cambridge, England). 144(2)
The signal-induced proliferation associated family of proteins comprises four members, SIPA1 and SIPA1L1-1L3. Mutations of the human SIPA1L3 gene result in congenital cataracts. In Xenopus, loss of Sipa1l3 function led to a severe eye phenotype that
Publikováno v:
Development genes and evolution. 226(5)
The signal-induced proliferation-associated (SIPA) protein family belongs to the RapGAP protein superfamily. Previous studies mainly focused on the expression and function of SIPA genes in vertebrate neuronal tissue. Only limited data about the embry