Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Melanie Rall"'
Publikováno v:
Cell Death and Disease, Vol 12, Iss 10, Pp 1-14 (2021)
Abstract The recently discovered p53-dependent DNA damage tolerance (DDT) pathway relies on its biochemical activities in DNA-binding, oligomerization, as well as complex formation with the translesion synthesis (TLS) polymerase iota (POLι). These p
Externí odkaz:
https://doaj.org/article/c2ffa96a58b34f0bb8aa8a21cb59c600
Autor:
Shahar Biechonski, Leonid Olender, Adi Zipin-Roitman, Muhammad Yassin, Nasma Aqaqe, Victoria Marcu-Malina, Melanie Rall-Scharpf, Magan Trottier, M. Stephen Meyn, Lisa Wiesmüller, Katia Beider, Yael Raz, Dan Grisaru, Arnon Nagler, Michael Milyavsky
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract Failure to precisely repair DNA damage in self-renewing Hematopoietic Stem and early Progenitor Cells (HSPCs) can disrupt normal hematopoiesis and promote leukemogenesis. Although HSPCs are widely considered a target of ionizing radiation (I
Externí odkaz:
https://doaj.org/article/9313fac1c8ce4adb8917c5a6468462c9
DTX3L and USP28 fine-tune DNA double strand repair through mutual regulation of their protein levels
Autor:
Yashwanth Ashok, Daniela Mennerich, Carlos Vela-Rodríguez, Heli I. Alanen, Melanie Rall-Scharpf, Lisa Wiesmüller, Renata Prunskaite-Hyyryläinen, Lari Lehtiö, Thomas Kietzmann
The DNA damage response involves a complex protein network with members mediating different post-translational modifications such as ubiquitination and deubiquitination. Thereby the E3 ubiquitin ligase DTX3L as well as the deubiquitinase USP28 are re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d009846c2fe6abd4155517a3392094fd
https://doi.org/10.1101/2023.01.30.526213
https://doi.org/10.1101/2023.01.30.526213
Sex-specific differences in DNA double-strand break repair of cycling human lymphocytes during aging
Autor:
Michael Milyavsky, Michael Denkinger, Melanie Rall-Scharpf, Thomas W. P. Friedl, Lisa Wiesmüller, Shahar Biechonski
Publikováno v:
Aging (Albany NY)
The gender gap in life expectancy and cancer incidence suggests differences in the aging process between the sexes. Genomic instability has been recognized as a key factor in aging, but little is known about sex-specific differences. Therefore, we an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbbc180ccf6e673228c8aaa7c1bb3cc2
https://doi.org/10.18632/aging.203519
https://doi.org/10.18632/aging.203519
Publikováno v:
Cell Death and Disease, Vol 12, Iss 10, Pp 1-14 (2021)
Cell Death & Disease
Cell Death & Disease
The recently discovered p53-dependent DNA damage tolerance (DDT) pathway relies on its biochemical activities in DNA-binding, oligomerization, as well as complex formation with the translesion synthesis (TLS) polymerase iota (POLι). These p53-POLι
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b28d43d97cd053c18689fd01e944fc75
Autor:
David Elad, Lisa Wiesmüller, Adi Zipin-Roitman, Dan Grisaru, Luba Trakhtenbrot, Shahar Biechonski, Michael Milyavsky, Ariel J. Jaffa, Melanie Rall, Leonid Olender, Dana Gourevich, Muhammad Yassin, Yael Raz, Nasma Aqaqe
Publikováno v:
International Journal of Cancer. 140:864-876
Quercetin (Que) is an abundant flavonoid in the human diet and high-concentration food supplement with reported pro- and anti-carcinogenic activities. Topoisomerase II (TopoII) inhibition and subsequent DNA damage induction by Que was implicated in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cbb2f5e49cd49461feb6d98fd496f6e
https://doi.org/10.1002/ijc.30497
https://doi.org/10.1002/ijc.30497
Autor:
Claudia Fournier, H. Bönig, Daniela Kraft, E. Metzler, Meta Volcic, Andreea Stahl, L Bauer, Melanie Rall, Daniela Salles, Elena Nasonova, Lisa Wiesmüller, A. Groo, Gisela Taucher-Scholz
Publikováno v:
Leukemia. 29:1543-1554
Hematopoietic stem and progenitor cells (HSPC), that is, the cell population giving rise not only to all mature hematopoietic lineages but also the presumed target for leukemic transformation, can transmit (adverse) genetic events, such as are acquir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48642c389d9a6162a54b57e7db69cecb
https://doi.org/10.1038/leu.2015.28
https://doi.org/10.1038/leu.2015.28
Autor:
Michael Milyavsky, Muhammad Yassin, Arnon Nagler, Magan Trottier, Adi Zipin-Roitman, Melanie Rall-Scharpf, Yael Raz, Shahar Biechonski, Nasma Aqaqe, Lisa Wiesmüller, Leonid Olender, Katia Beider, Victoria Marcu-Malina, M. Stephen Meyn, Dan Grisaru
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Failure to precisely repair DNA damage in self-renewing Hematopoietic Stem and early Progenitor Cells (HSPCs) can disrupt normal hematopoiesis and promote leukemogenesis. Although HSPCs are widely considered a target of ionizing radiation (IR)-induce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78b4fe1b50d1027a534ee663a0473ac5
https://pubmed.ncbi.nlm.nih.gov/29666389
https://pubmed.ncbi.nlm.nih.gov/29666389
Publikováno v:
Leukemia. 32(1)
The breakpoint cluster region of the MLL gene (MLLbcr) is frequently rearranged in therapy-related and infant acute leukaemia, but the destabilizing mechanism is poorly understood. We recently proposed that DNA replication stress results in MLLbcr cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b825f0d3837d9c219ffdf86768ffd844
https://pubmed.ncbi.nlm.nih.gov/28626219
https://pubmed.ncbi.nlm.nih.gov/28626219
Autor:
Shahar, Biechonski, Dana, Gourevich, Melanie, Rall, Nasma, Aqaqe, Muhammad, Yassin, Adi, Zipin-Roitman, Luba, Trakhtenbrot, Leonid, Olender, Yael, Raz, Ariel J, Jaffa, Dan, Grisaru, Lisa, Wiesmuller, David, Elad, Michael, Milyavsky
Publikováno v:
International journal of cancer. 140(4)
Quercetin (Que) is an abundant flavonoid in the human diet and high-concentration food supplement with reported pro- and anti-carcinogenic activities. Topoisomerase II (TopoII) inhibition and subsequent DNA damage induction by Que was implicated in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::de6bd32971dcaa937780ce85b66d3757
https://pubmed.ncbi.nlm.nih.gov/27813122
https://pubmed.ncbi.nlm.nih.gov/27813122