Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Melanie R. Mark"'
Autor:
A. Gurney, R.M. Pitti, Melanie R. Mark, Arthur J Huang, Alane M. Gray, Patrick Dowd, Paulj. Godowski, S. Marsters, K.P. Baker, Daryl T. Baldwin, A.D. Goddard, Jennifer Brush, Peter Schow, Sherry Heldens, Avi Ashkenazi, William I. Wood
Publikováno v:
Current Biology. 9(4):215-218
The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate diverse biological functions, including cell proliferation, differentiation, and survival [1] [2] [3]. We have identified a new TNF-related ligand, designated human G
Autor:
Jian Chen, Helga Raab, R. Glenn Hammonds, Paul J. Godowski, Michael D. Sadick, Melanie R. Mark
Publikováno v:
Cell. 82(3):355-358
Autor:
Melanie R. Mark, Paul J. Godowski, David T. Scadden, Qimin Gu, Kathleen A. Gallo, Zhengyu Wang
Publikováno v:
Journal of Biological Chemistry. 269:15092-15100
Protein kinase play important roles in the growth and differentiation of cells. We have isolated cDNA clones from the human megakaryocytic cell line CMK11-5 that encode a novel protein kinase, which we call SPRK (src-homology 3 (SH3) domain-containin
Autor:
Qimin Gu, Paul J. Godowski, David T. Scadden, Audrey San Francisco Goddard, Zhengyu Wang, Melanie R. Mark
Publikováno v:
Journal of Biological Chemistry. 269:10720-10728
We have isolated cDNA clones that encode the human and murine forms of a novel receptor-type tyrosine kinase termed Rse. Sequence analysis indicates that human Rse contains 890 amino acids, with an extracellular region composed of two immunoglobulin-
Publikováno v:
Journal of Biological Chemistry. 267:26166-26171
The receptor for hepatocyte growth factor (HGF) is the product of the c-met proto-oncogene, a membrane-spanning tyrosine kinase receptor. To facilitate analysis of HGF and its receptor (HGFr), we expressed and purified a chimeric protein containing t
Autor:
H S Phillips, R G Hammonds, Franz Hefti, Janet Valverde, Paul J. Godowski, A. Shih, Melanie R. Mark, Paul Moran, Karen S. Chen, Laurie J. Goodman, Ingrid W. Caras, Klaus D. Beck, John W. Winslow, Mark Armanini, Merry Nishimura
Publikováno v:
Ciba Foundation Symposium 196-Growth Factors as Drugs for Neurological and Sensory Disorders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bde1a0e4e2122bca2ab6b8cd431ee03
https://doi.org/10.1002/9780470514863.ch5
https://doi.org/10.1002/9780470514863.ch5
Autor:
Ming-Hong Xie, Bernard Chow, James Lee, Audrey Goddard, Daryl T. Baldwin, Yisheng Jin, Kevin P. Baker, Sherry Heldens, Guoying Yu, Paul J. Godowski, Jean Yuan, Christopher Grimaldi, Jennifer Singh, Alicia Vagts, Clarissa Chui, Dongzhou Liao, Bethanne Deuel, Austin L. Gurney, Min Zhang, Daniel G. Yansura, David Wieand, Patrick Dowd, William I. Wood, Qimin Gu, Lhney Lewis, Somasekar Seshagiri, Jill Schoenfeld, Kathryn Woods, Richard Vandlen, Laura Klimowski, Evangeline Abaya, Zemin Zhang, Melanie R. Mark, Jeremy Stinson, Edward P. Robbie, Hok Seon Kim, Victoria Smith, Craig Crowley, Jessica Foster, Laura Simmons, Bridget Currell, Stephanie Johnson, Colin K. Watanabe, Dan L. Eaton, Jennifer Brush, Jian Chen, Hilary Clark, Sothy Yi, Philip E. Hass, Celina Sanchez, Arthur J Huang
A large-scale effort, termed the Secreted Protein Discovery Initiative (SPDI), was undertaken to identify novel secreted and transmembrane proteins. In the first of several approaches, a biological signal sequence trap in yeast cells was utilized to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85bfd6259edc7f041ff31d6f8b811d17
https://europepmc.org/articles/PMC403697/
https://europepmc.org/articles/PMC403697/
Autor:
Justin D. Radolf, Ruey-Bing Yang, Gary R. Klimpel, Arturo Zychlinsky, Paul J. Godowski, Shelly Suggett, Brigitte Devaux, Melanie R. Mark, Antonios O. Aliprantis
Publikováno v:
Science (New York, N.Y.). 285(5428)
Apoptosis is implicated in the generation and resolution of inflammation in response to bacterial pathogens. All bacterial pathogens produce lipoproteins (BLPs), which trigger the innate immune response. BLPs were found to induce apoptosis in THP-1 m
Publikováno v:
The Journal of biological chemistry. 271(16)
Rse, Ax1, and c-Mer comprise a family of cell adhesion molecule-related tyrosine kinase receptors. Human Gas6 was recently shown to act as a ligand for both human Rse (Godowski et al., 1995) and human Ax1 (Varnum et al., 1995). Gas6 contains an NH2-t
Publikováno v:
Tyrosine Phosphorylation/Dephosphorylation and Downstream Signalling ISBN: 9783642782497
Hepatocyte growth factor (HGF) exhibits mitogenic and/or motogenic activities for a variety of cells (see for review Matsumoto and Nakamura, 1992). Structurally, it has similarities to kringle-containing serine-proteases, although it does not possess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::119f5335a1dbbbb0f81e79630811636e
https://doi.org/10.1007/978-3-642-78247-3_8
https://doi.org/10.1007/978-3-642-78247-3_8