Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Melanie R Nicol"'
Autor:
Michael Ohene-Nyako, Sara R. Nass, Hope T. Richard, Robert Lukande, Melanie R. Nicol, MaryPeace McRae, Pamela E. Knapp, Kurt F. Hauser
Publikováno v:
ASN Neuro, Vol 15 (2023)
Aberrant phosphorylation and subsequent aggregation of the trans-activation response (TAR) element DNA binding protein 43 (TDP-43) is a common feature of multiple neurodegenerative disorders and contributes to disease severity. Here, we investigated
Externí odkaz:
https://doaj.org/article/40944578bd644a5e9ee9fadf91aff448
Publikováno v:
Journal of Clinical and Translational Science, Vol 7, Pp 89-90 (2023)
OBJECTIVES/GOALS: An ex-vivo tissue model has been developed to predict target concentrations of tenofovir diphosphate (TFVdp; active metabolite of tenofovir) but has not been utilized to see how vaginal dysbiosis affects TFVdp/dATP exposure in femal
Externí odkaz:
https://doaj.org/article/d8a89e33ad2548899164fa0be2a7a129
Autor:
Prosperity C. Eneh, Katherine Huppler Hullsiek, Daniel Kiiza, Joshua Rhein, David B. Meya, David R. Boulware, Melanie R. Nicol
Publikováno v:
BMC Infectious Diseases, Vol 20, Iss 1, Pp 1-11 (2020)
Abstract Background Management of co-infections including cryptococcal meningitis, tuberculosis and other opportunistic infections in persons living with HIV can lead to complex polypharmacotherapy and increased susceptibility to drug-drug interactio
Externí odkaz:
https://doaj.org/article/0b0345bbaf4e43659f34abcdcd6a57c4
Autor:
Katelyn A. Pastick, Richard Kwizera, Melanie R. Nicol, Robert Lukande, David B. Meya, David R. Boulware, Olivie C. Namuju, Jonee M. Taylor
Publikováno v:
Wellcome Open Research, Vol 6 (2022)
Background: Human immunodeficiency virus (HIV)-related mortality remains high in sub-Saharan Africa. Clinical autopsies can provide invaluable information to help ascertain the cause of death. We aimed to determine the rate and reasons for autopsy re
Externí odkaz:
https://doaj.org/article/2a5f7da586334e04afe4d98c52353bc9
Autor:
Melanie R. Nicol, Katelyn A. Pastick, Joneé Taylor, Olivie C. Namuju, Joshua Rhein, Darlisha A. Williams, David B. Meya, David R. Boulware, Robert Lukande
Publikováno v:
Clinical and Translational Science, Vol 12, Iss 5, Pp 445-449 (2019)
The central nervous system (CNS) is a known HIV reservoir, yet little is known about drug exposure in the brain. Our primary objective was to quantify exposure of three common antiretrovirals in brain tissue and compare exposures to plasma and cerebr
Externí odkaz:
https://doaj.org/article/cbd298f727f44e8daf595e5dd01ae1aa
Autor:
Marisa Brizzi, Elizabeth M. Sherman, Sarah B. Green, Diana N. Nowicki, Emily N. Drwiega, Melanie R. Nicol, Daniel B. Chastain, Eric G. Sahloff, William R. Truong, David Cluck, Melissa E. Badowski, Sarah M. Michienzi, Spencer H. Durham
Publikováno v:
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 43:305-320
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df773238123581c8431120a97da08afc
https://doi.org/10.1002/phar.2796
https://doi.org/10.1002/phar.2796
Autor:
Fan Wang, Olivie C Namuju, Katelyn A Pastick, Kizito Abdusalaamu, Usha Mishra, Lindsey Collins, David R Boulware, Robert Lukande, David B Meya, Melanie R Nicol
Publikováno v:
J Antimicrob Chemother
Background Optimal penetration of anti-infectives in the female genital tract (FGT) is paramount in the treatment and prevention of infectious diseases. While exposure of anti-infectives in lower FGT tissues (e.g. cervix, vagina) has been described,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::701f1d9e5fd0b7c5331a7806efb34020
https://doi.org/10.1093/jac/dkac300
https://doi.org/10.1093/jac/dkac300
Autor:
Jayne Ellis, Prosperity C. Eneh, Kenneth Ssebambulidde, Morris K. Rutakingirwa, Mohammed Lamorde, Joshua Rhein, Fiona V. Cresswell, David R. Boulware, Melanie R. Nicol
Publikováno v:
Wellcome Open Research, Vol 3 (2019)
In 2016, 10.4 million cases of tuberculosis (TB) were reported globally. Malaria also continues to be a global public health threat. Due to marked epidemiological overlap in the global burden of TB and malaria, co-infection does occur. An HIV-infecte
Externí odkaz:
https://doaj.org/article/1ff459de0fbc4f709e1764965c290edd
Autor:
Melanie R. Nicol, Fan Wang, Ambayo Richard, Olivie Carolyne Namuju, Katelyn A Pastick, David R Boulware, David B Meya, Robert Lukande
Publikováno v:
Journal of Clinical and Translational Science, Vol 5, Pp 96-96 (2021)
ABSTRACT IMPACT: Plasma and CSF are not reliable estimates of drug exposure in tissue compartments relevant for treatment and prevention of infectious diseases. OBJECTIVES/GOALS: Globally, high dose fluconazole is widely used in the management of cry
Externí odkaz:
https://doaj.org/article/cbed734194ba496c97b392613caa7495
Autor:
Alyssa Lantz, Melanie R Nicol
Publikováno v:
AIDS research and human retroviruses. 38(12)
The HIV epidemic remains a significant public health burden. Women represent half of the global HIV epidemic, yet there is an urgent need for a variety of prevention options to meet the needs of more women. Pre-exposure prophylaxis (PrEP) is a valuab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::177050d67e8ed59bd179c21ab631961b
https://pubmed.ncbi.nlm.nih.gov/36097755
https://pubmed.ncbi.nlm.nih.gov/36097755